BRCU Qs Flashcards
TSC associated with
facial skin lesions, angiomyolipoma
-autosomal dom
- mental retardation
Ca Ox crystal mechanism
hyperoxaluria d/t malabsorption from weight loss procedure/medication, Calcium saponified by fat, free Oxalate reabsorbed
AKI, pancreatitis, low C3/C4, low +ANA titer - dx?
IgG4 disease - plasma cell infiltrate, storiform cartwheel pattern
- maybe eosinophilia with low grade +ANA
*sarcoid/myeloma have normal complement
Lead nephropathy triad
CKD, gout, HTN w/ heavy metal exposure
*cadmium in battery - HTN/CKD but also tubulointerstital nephritis with bone disease/stones
Chiese herb/aristolochia is associated with?
risk of transitional cell carcinoma/isomorphic hematuria and chronic interstitial nephritis
HTN, hypoK, metabolic alkalosis in Asian - think dx?
“apparent” mineralicorticoid excess from glycerrhizic in tea
- causes AIN
- star fruit cause Ox nephropathy
- noni juice - hyperkalemia
NSAIDs cause what GN?
NS, MCD, also AIN (eos, rash, fever)
- Lead uses organic cation in PCT
- Gold causes NS from MN
Best urine marker of dietary acid intake?
Ur Sulfate
- inc acid, low pH = uric acid stone
Hexagonal urinary crystal - stone?
Cystine stone
- tx: high Ur pH to dissolve cystine, restrict dietary protein
- alpha-mercaptopropionyglycine
- autosomal recessive
AIN from PCN - presentation
fever, rash, eosinophilia
T-cell from type IV hypersensitivity, CD8 origin
- subnephrotic (NSAIDs would be nephrotic)
List some diseases associated with granulomatous AIN
- TINU
- sarcoid
- wegener’s
- Crohn’s
- drug-induced
- TB
- Behcets
+Trichrome stain indicated the presence of ?
collagen/fibrosis - CKD
- bad in AIN
Why is atazanavir poorly soluble/causes stones?
needs a low pH <4.5 and high urine volume to prevent precipitation
- acyclovir, more crystals vs stones
tenofovir - prox ATI/fanconi
MCC med of AIN worldwide
antimicrobials/PPI
Aristolochic acid is also associated with what nephropathy?
balkan
