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Comprehensive Drug Review > Brand Name, Class, MOA > Flashcards

Brand Name, Class, MOA Flashcards

1
Q

Capoten

A

Captopril, ACEI, Prevents conversion of angiotensin I to Angiotensin II (potent vasoconstrictor) by competitive inhibition of ACE. Results in lower BP secondary to lower levels of angiotensin II, increased levels of plasma renin activity, and a reduction in aldosterone secretion.

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2
Q

Vasotec

A

Enalapril, ACEI, Prevents conversion of angiotensin I to Angiotensin II (potent vasoconstrictor) by competitive inhibition of ACE. Results in lower BP secondary to lower levels of angiotensin II, increased levels of plasma renin activity, and a reduction in aldosterone secretion.

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3
Q

Zestril, Prinivil

A

Lisinopril, ACEI, Prevents conversion of angiotensin I to Angiotensin II (potent vasoconstrictor) by competitive inhibition of ACE. Results in lower BP secondary to lower levels of angiotensin II, increased levels of plasma renin activity, and a reduction in aldosterone secretion.

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4
Q

Altace

A

Ramipril, ACEI, Prevents conversion of angiotensin I to Angiotensin II (potent vasoconstrictor) by competitive inhibition of ACE. Results in lower BP secondary to lower levels of angiotensin II, increased levels of plasma renin activity, and a reduction in aldosterone secretion.

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5
Q

Mavik

A

Trandolapril, ACEI, Prevents conversion of angiotensin I to Angiotensin II (potent vasoconstrictor) by competitive inhibition of ACE. Results in lower BP secondary to lower levels of angiotensin II, increased levels of plasma renin activity, and a reduction in aldosterone secretion.

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6
Q

Cozaar

A

Losartan, ARB, Selective, competitive angiotensin II receptor type 1 receptor antagonist, reducing the end-organ responses to angiotensin II. Results in a decrease in total peripheral resistance (afterload) and cardiac venous return (prelaod). Reduction in BP occurs independently of the status of the renin-angiotensin system.

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7
Q

Avapro

A

Irbesartan, ARB, Selective, competitive angiotensin II receptor type 1 receptor antagonist, reducing the end-organ responses to angiotensin II. Results in a decrease in total peripheral resistance (afterload) and cardiac venous return (prelaod). Reduction in BP occurs independently of the status of the renin-angiotensin system.

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8
Q

Atacand

A

Candesartan, ARB, Selective, competitive angiotensin II receptor type 1 receptor antagonist, reducing the end-organ responses to angiotensin II. Results in a decrease in total peripheral resistance (afterload) and cardiac venous return (prelaod). Reduction in BP occurs independently of the status of the renin-angiotensin system.

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9
Q

Benicar

A

Olmesartan, ARB, Selective, competitive angiotensin II receptor type 1 receptor antagonist, reducing the end-organ responses to angiotensin II. Results in a decrease in total peripheral resistance (afterload) and cardiac venous return (prelaod). Reduction in BP occurs independently of the status of the renin-angiotensin system.

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10
Q

Micardis

A

Telmisartan, ARB, Selective, competitive angiotensin II receptor type 1 receptor antagonist, reducing the end-organ responses to angiotensin II. Results in a decrease in total peripheral resistance (afterload) and cardiac venous return (prelaod). Reduction in BP occurs independently of the status of the renin-angiotensin system.

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11
Q

Diovan

A

Valsartan, ARB, Selective, competitive angiotensin II receptor type 1 receptor antagonist, reducing the end-organ responses to angiotensin II. Results in a decrease in total peripheral resistance (afterload) and cardiac venous return (prelaod). Reduction in BP occurs independently of the status of the renin-angiotensin system.

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12
Q

Tekturna

A

Aliskiren, Direct Renin Inhibitor, decreases plasma renin activity and inhibits the conversion of angiotensinogen to angiotensin I.

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13
Q

Tenormin

A

Atenolol, Beta Blocker, competitive inhibition of beta-blockers.

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14
Q

Zebeta

A

Bisoprolol, Beta Blocker, competitive inhibition of beta-blockers.

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15
Q

Lopressor, Toprol- XL

A

Metoprolol, Beta Blocker, competitive inhibition of beta-blockers.

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16
Q

Inderal (LA)

A

Propranolol, Beta Blocker, competitive inhibition of beta-blockers.

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17
Q

Coreg (CR)

A

Carvedilol, Beta Blocker, competitive inhibition of beta-blockers.

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18
Q

Trandate

A

Labetalol, Beta Blocker, competitive inhibition of beta-blockers.

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19
Q

Microzide

A

HCTZ, Thiazide diuretic, acts on kidneys to reduce Na reabsorption in the distal convoluted tubule. Impairs Na transport in the distal convoluted tubule, natiuresis and concomitant water loss is induced.

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20
Q

Chlorthalidone (generic)

A

Thiazide diuretic, acts on kidneys to reduce Na reabsorption in the distal convoluted tubule. Impairs Na transport in the distal convoluted tubule, natiuresis and concomitant water loss is induced.

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21
Q

Indapamide (generic)

A

Thiazide diuretic, acts on kidneys to reduce Na reabsorption in the distal convoluted tubule. Impairs Na transport in the distal convoluted tubule, natiuresis and concomitant water loss is induced.

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22
Q

Zaroxolyn

A

Metolazone, Thiazide diuretic, acts on kidneys to reduce Na reabsorption in the distal convoluted tubule. Impairs Na transport in the distal convoluted tubule, natiuresis and concomitant water loss is induced. (Not for HTN?)

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23
Q

Lasix

A

Furosemide, Loop diuretics, reversibly binds to the Na, K, Cl cotransport mechanism on the luminal side of the ascending loop of Henle, thereby inhibiting the active reabsorption of these ions.

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24
Q

Bumex

A

Bumetanide, Loop diuretics, reversibly binds to the Na, K, Cl cotransport mechanism on the luminal side of the ascending loop of Henle, thereby inhibiting the active reabsorption of these ions.

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25
Q

Demadex

A

Torsemide, Loop diuretics, reversibly binds to the Na, K, Cl cotransport mechanism on the luminal side of the ascending loop of Henle, thereby inhibiting the active reabsorption of these ions.

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26
Q

Edecrin

A

Ethacrynic acid, Loop diuretics, reversibly binds to the Na, K, Cl cotransport mechanism on the luminal side of the ascending loop of Henle, thereby inhibiting the active reabsorption of these ions.

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27
Q

Amiloride (generic)

A

K+ sparing, blocks the epithelial Na channel on the luminal side of the kidney collecting tubule. Na channel blockers directly inhibit the entry of Na in to the Na channels.

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28
Q

Dyrenium

A

Triamterene, K+ sparing, blocks the epithelial Na channel on the luminal side of the kidney collecting tubule. Na channel blockers directly inhibit the entry of Na in to the Na channels.

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29
Q

Norvasc

A

Amlodipine, DHP CCB, act by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance, and hence reducing BP, in angina they increase bloodflow to the heart.

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30
Q

Plendil

A

Felodipine, DHP CCB, act by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance, and hence reducing BP, in angina they increase bloodflow to the heart.

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31
Q

Cardene SR

A

Nicardipine, DHP CCB, act by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance, and hence reducing BP, in angina they increase bloodflow to the heart.

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32
Q

Adalat, Procardia

A

Nifedipine, DHP CCB, act by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance, and hence reducing BP, in angina they increase bloodflow to the heart.

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33
Q

Cardiazem

A

Diltiazem, Non-DHP CCB, Act as a potent vasodilator of coronary vessels, increasing bloodflow and decreasing the HR by strong depression of atrioventricular node conduction. Also, acts as a potent vasodilator of peripheral vessels, reducing peripheral resistance and afterload. Has negative ionotropic effects.

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34
Q

Verapamil (generic)

A

Non-DHP CCB, Act as a potent vasodilator of coronary vessels, increasing bloodflow and decreasing the HR by strong depression of atrioventricular node conduction. Also, acts as a potent vasodilator of peripheral vessels, reducing peripheral resistance and afterload. Has negative ionotropic effects.

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35
Q

Cardura

A

Doxazosin, Alpha 1 blockers, selective alpha1 antagonist that works by blocking the action of adrenaline on smooth muscle of the blood vessel walls.

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36
Q

Minipress

A

Prazosin, Alpha 1 blockers, selective alpha1 antagonist that works by blocking the action of adrenaline on smooth muscle of the blood vessel walls.

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37
Q

Hytrin

A

Terazosin, Alpha 1 blockers, selective alpha1 antagonist that works by blocking the action of adrenaline on smooth muscle of the blood vessel walls.

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38
Q

Aldactone

A

Spironolactone, Aldosterone Receptor Blockers, inhibit the effect of aldosterone by competing for intracellular aldosterone receptors in the cortical collecting duct. This decreases the reabsorption of Na+ and water while decreasing the secretion of K+.

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39
Q

Inspra

A

Eplerenone, Aldosterone Receptor Blockers, inhibit the effect of aldosterone by competing for intracellular aldosterone receptors in the cortical collecting duct. This decreases the reabsorption of Na+ and water while decreasing the secretion of K+.

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40
Q

Catapres

A

Clonidine, Central alpha 2 agonist, stimulates alpha2 receptors in the brain, which decreases sympathetic outflow cardiac output and peripheral vascular resistance, lowering BP and HR.

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41
Q

Aldomet

A

Methyldopa, Central alpha 2 agonist, stimulates alpha2 receptors in the brain, which decreases sympathetic outflow cardiac output and peripheral vascular resistance, lowering BP and HR.

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42
Q

Intuniv, Tenex

A

Guanfacine, Central alpha 2 agonist, stimulates alpha2 receptors in the brain, which decreases sympathetic outflow cardiac output and peripheral vascular resistance, lowering BP and HR.

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43
Q

Apresoline

A

Hydralazine, Vasodilator, direct acting smooth muscle relaxant that acts as a vasodilator primarily in arteries and arterioles.

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44
Q

Loniten

A

Minoxidil, Vasodilator, direct acting smooth muscle relaxant that acts as a vasodilator primarily in arteries and arterioles.

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45
Q

Lipitor

A

Atorvastatin, HMG-CoA Reductase Inhibitor,Very similar to HMG-CoA, so they get reduced instead of acutal HMG-CoA. Less HMG-CoA is reduced to mevalonate (rate limiting step in production of cholesterol). Less cholesterol is produced.

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46
Q

Lescol

A

Fluvastatin, HMG-CoA Reductase Inhibitor,Very similar to HMG-CoA, so they get reduced instead of acutal HMG-CoA. Less HMG-CoA is reduced to mevalonate (rate limiting step in production of cholesterol). Less cholesterol is produced.

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47
Q

Mevacor

A

Lovastatin, HMG-CoA Reductase Inhibitor,Very similar to HMG-CoA, so they get reduced instead of acutal HMG-CoA. Less HMG-CoA is reduced to mevalonate (rate limiting step in production of cholesterol). Less cholesterol is produced.

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48
Q

Altacor

A

Lovastatin ER, HMG-CoA Reductase Inhibitor,Very similar to HMG-CoA, so they get reduced instead of acutal HMG-CoA. Less HMG-CoA is reduced to mevalonate (rate limiting step in production of cholesterol). Less cholesterol is produced.

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49
Q

Livalo

A

Pitavastatin, HMG-CoA Reductase Inhibitor,Very similar to HMG-CoA, so they get reduced instead of acutal HMG-CoA. Less HMG-CoA is reduced to mevalonate (rate limiting step in production of cholesterol). Less cholesterol is produced.

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50
Q

Pravachol

A

Pravastatin, HMG-CoA Reductase Inhibitor,Very similar to HMG-CoA, so they get reduced instead of acutal HMG-CoA. Less HMG-CoA is reduced to mevalonate (rate limiting step in production of cholesterol). Less cholesterol is produced.

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51
Q

Zocor

A

Simvastatin, HMG-CoA Reductase Inhibitor,Very similar to HMG-CoA, so they get reduced instead of acutal HMG-CoA. Less HMG-CoA is reduced to mevalonate (rate limiting step in production of cholesterol). Less cholesterol is produced.

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52
Q

Crestor

A

Rosuvastatin, HMG-CoA Reductase Inhibitor,Very similar to HMG-CoA, so they get reduced instead of acutal HMG-CoA. Less HMG-CoA is reduced to mevalonate (rate limiting step in production of cholesterol). Less cholesterol is produced.

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53
Q

Niacin

A

Vitamin B3, Inhibits the hepatic production of VLDL and consequently its metabolite LDL-C.

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54
Q

Zetia

A

Exetimibe, Cholesterol absorption inhibitor, selective inhibitor of dietary and biliary cholesterol absorption.

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55
Q

Questran

A

Cholestryramine, Bile Acid Sequestrant, Binds bile acids in the intestine, decreasing biliary cholesterol absorption.

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56
Q

Welchol

A

Colesevelam, Bile Acid Sequestrant, Binds bile acids in the intestine, decreasing biliary cholesterol absorption.

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57
Q

Tricor

A

Fenofibrate, Fibrate, peroxisome proliferator-activated receptor alpha activation. Reduced hepatic secretion of VLDL, Induction of lipoprotein lipase- mediated lipolysis and clearance of TG.

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58
Q

Lopid

A

Gemfibrozil, Fibrate, peroxisome proliferator-activated receptor alpha activation. Reduced hepatic secretion of VLDL, Induction of lipoprotein lipase- mediated lipolysis and clearance of TG.

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59
Q

Lotensin HTC

A

Benazepril and HCTZ (ACEI and thaizide)

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60
Q

Capozide

A

Captopril and HCTZ

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61
Q

Vaseretic

A

Enalapril and HCTZ

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62
Q

Prinzide, Zestoretic

A

Lisinopril and HCTZ

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63
Q

Uniretic

A

Moexipril and HCTZ

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64
Q

Hyzaar

A

Losartan and HCTZ

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65
Q

Diovan HCT

A

Valsartan and HCTZ

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66
Q

Tenoretic

A

Atenolol and Chlorthalidone

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67
Q

Ziac

A

Bisoprolol and HCTZ

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68
Q

Lopressor HCT

A

Metoprolol and HCTZ

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69
Q

Corzide

A

Nadolol and Benzoflumethazide

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70
Q

Inderide

A

Timolol and HCTZ

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71
Q

Timolide

A

Timolol and HCTZ

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72
Q

Lotrel

A

Amlodipine and Benazepril

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73
Q

Lexxel

A

Felodipine and Enalapril

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74
Q

Tarka

A

Verapamil and Trandolapril

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75
Q

Moduretic

A

Amlodipine and HCTZ

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76
Q

Aldactazide

A

Spironolactone and HCTZ

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77
Q

Maxzide

A

Triamterene and HCTZ

78
Q

Combipres

A

Clonidine and Chlorthalidone

79
Q

Apresazide

A

Hydralazine and HCTZ

80
Q

Aldoril

A

Methyldopa and HCTZ

81
Q

Minizide

A

Prazosin and Polythiazide

82
Q

Diabinese

A

Chlorpropamide, sulfonylurea, stimulates insulin secretion in beta cells (secretagogue) by binding to K+ channels causing depolarization, leads to Ca2+ influx increasing insulin release. Also decreases insulin resistance and hepatic glucose output.

83
Q

Glucotrol

A

Glipizide, sulfonylurea, stimulates insulin secretion in beta cells (secretagogue) by binding to K+ channels causing depolarization, leads to Ca2+ influx increasing insulin release. Also decreases insulin resistance and hepatic glucose output.

84
Q

Diabeta, Glynase

A

Glyburide, sulfonylurea, stimulates insulin secretion in beta cells (secretagogue) by binding to K+ channels causing depolarization, leads to Ca2+ influx increasing insulin release. Also decreases insulin resistance and hepatic glucose output.

85
Q

Amaryl

A

Glimeperide, sulfonylurea, stimulates insulin secretion in beta cells (secretagogue) by binding to K+ channels causing depolarization, leads to Ca2+ influx increasing insulin release. Also decreases insulin resistance and hepatic glucose output.

86
Q

Glucophage

A

Metformin, biguanide, enhances insulin sensitivity of both hepatic and muscle tissues (possibly by activating AMPK), allows for an increased uptake of glucose into these insulin-sensitive tissues

87
Q

Actos

A

Pioglitazone, TZD, act on ppar gamma which results in glucose uptake (fat cells) and decreases hepatic glucose output and ultimately increases insulin sensitivity.

88
Q

Avandia

A

Rosiglitazone, TZD, act on ppar gamma which results in glucose uptake (fat cells) and decreases hepatic glucose output and ultimately increases insulin sensitivity

89
Q

Prandin

A

Repaglinide, meglitinide, stimulate the release of insulin from the beta pancreatic cells in the same manner that the sulfonlureas do (secretagogues), bind to/blocks K cannel > depolarization of cell > opens Ca channel > Ca influx causes release of insulin.

90
Q

Starlix

A

Nateglinide, meglitinide, stimulate the release of insulin from the beta pancreatic cells in the same manner that the sulfonlureas do (secretagogues), bind to/blocks K cannel > depolarization of cell > opens Ca channel > Ca influx causes release of insulin.

91
Q

Precose

A

Acarbose, alpha-glucosidase inhibitor, compeitively inhibits enzymes (maltase, isomaltase, sucrase, and glucoamylase) in the small intestine, delaying the breakdown of sucrose and complex carbohydrates, results in reduction of the postprandial blood glucose rise.

92
Q

Glyset

A

Miglitol, alpha-glucosidase inhibitor, compeitively inhibits enzymes (maltase, isomaltase, sucrase, and glucoamylase) in the small intestine, delaying the breakdown of sucrose and complex carbohydrates, results in reduction of the postprandial blood glucose rise.

93
Q

Symlin

A

Pramlintide, amylinomimetic, synthetic analog of amylin, a neurohormone co-secreted from the cells with insulin. it suppresses inappropraitely high postprandial glucagon secretion, increases satiety, which may result in weight loss, and slows gastric emptying so that the rate of glucose appearance into the plasma better matches the glucose disposition.

94
Q

Byetta

A

Exenatide, GLP-Analogue, enhances glucose dependent insulin secretion while suppressing inappropriately high postprandial glucagon secretion in the presence of elevated glucose concentrations, resulting in a reduction in hepatic glucose production.

95
Q

Victoza

A

Liraglutide, GLP-1 receptor agonist, enhances glucose-dependent insulin secretion while suppressing inappropriately high glucagon secretion in the presence of elevated glucose concentrations, resulting in a reduction in hepatic glucose production.

96
Q

Januvia

A

Sitagliptin, DPP-4 inhibitor, prolong the half-life of endogenously produced GlP-1 and GIP (normally only minutes). As these agents block nearly 100% of the DPP-4 enzyme for at least 12 hours, normal physiologic, nondiabetic GLP-1 levels are achieved. Significantly reduces the inappropriately elevated glucagon postprandially, though not back to nondiabetic levels, and improve insulin response to a high glucose level. Insulin levels tend to be unchanged with DPP-4 inhibitors, but glucose levels are reduced.

97
Q

Onglyza

A

Saxagliptin, DPP-4 inhibitor, prolong the half-life of endogenously produced GlP-1 and GIP (normally only minutes). As these agents block nearly 100% of the DPP-4 enzyme for at least 12 hours, normal physiologic, nondiabetic GLP-1 levels are achieved. Significantly reduces the inappropriately elevated glucagon postprandially, though not back to nondiabetic levels, and improve insulin response to a high glucose level. Insulin levels tend to be unchanged with DPP-4 inhibitors, but glucose levels are reduced.

98
Q

Nesina

A

Alogliptin, DPP-4 inhibitor, prolong the half-life of endogenously produced GlP-1 and GIP (normally only minutes). As these agents block nearly 100% of the DPP-4 enzyme for at least 12 hours, normal physiologic, nondiabetic GLP-1 levels are achieved. Significantly reduces the inappropriately elevated glucagon postprandially, though not back to nondiabetic levels, and improve insulin response to a high glucose level. Insulin levels tend to be unchanged with DPP-4 inhibitors, but glucose levels are reduced.

99
Q

Tradjenta

A

Linagliptin, DPP-4 inhibitor, prolong the half-life of endogenously produced GlP-1 and GIP (normally only minutes). As these agents block nearly 100% of the DPP-4 enzyme for at least 12 hours, normal physiologic, nondiabetic GLP-1 levels are achieved. Significantly reduces the inappropriately elevated glucagon postprandially, though not back to nondiabetic levels, and improve insulin response to a high glucose level. Insulin levels tend to be unchanged with DPP-4 inhibitors, but glucose levels are reduced.

100
Q

Invokana

A

Canaglifozin, sodium glucose transporters, inhibits SGT2 in promixal renal tubules and reduces reabsorption of glucose which lowers the renal threshold for glucose.

101
Q

Whelcol

A

Colesevelam, bile acid sequestrants, binds bile acid in the intestinal lumen, decreasing the bile acid pool for reabsorption. Lowers plasma glucose levels in the intestinal lumen or a systemic effect due to the intestinal lumen effect or some combination of these two.

102
Q

Cycloset, Parlodel

A

Bromocriptine mesylate, Dopamine agonsit, MOA unknown.

103
Q

Trulicity

A

Dulaglutide, GLP-1 receptor agonist, enhances glucose-dependent insulin secretion while suppressing inappropriately high glucagon secretion in the presence of elevated glucose concentrations, resulting in a reduction in hepatic glucose production.

104
Q

Farxiga

A

Dapagliflozin, sodium glucose transporters, inhibits SGT2 in promixal renal tubules and reduces reabsorption of glucose which lowers the renal threshold for glucose.

105
Q

Cladiribine (generic)

A

Anti-metabolite, Trick DNA into thinking it is utilizing a healthy purine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

106
Q

Clofarabine (generic)

A

Anti-metabolite, Trick DNA into thinking it is utilizing a healthy purine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

107
Q

Fludarabine (generic)

A

Anti-metabolite, Trick DNA into thinking it is utilizing a healthy purine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

108
Q

Mercaptopurine (generic)

A

Anti-metabolite, Trick DNA into thinking it is utilizing a healthy purine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

109
Q

Nelarabine (generic)

A

Anti-metabolite, Trick DNA into thinking it is utilizing a healthy purine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

110
Q

Pentostatin (generic)

A

Anti-metabolite, Trick DNA into thinking it is utilizing a healthy purine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

111
Q

Thioguanine (generic)

A

Anti-metabolite (purine), Trick DNA into thinking it is utilizing a healthy purine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

112
Q

Xeloda

A

Capcitabine (oral) anti-metabolite (pyrimidine), Trick DNA into thinking it is utilizing a healthy pyrimidine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

113
Q

ARA-C

A

Citarabine (liposomal), anti-metabolite (pyrimidine), Trick DNA into thinking it is utilizing a healthy pyrimidine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

114
Q

Floxuridine (gen)

A

anti-metabolite (pyrimidine), Trick DNA into thinking it is utilizing a healthy pyrimidine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

115
Q

5-FU

A

Flurouricil, anti-metabolite (pyrimidine), Trick DNA into thinking it is utilizing a healthy pyrimidine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

116
Q

Gemzar

A

Gemcitabine, anti-metabolite (pyrimidine), Trick DNA into thinking it is utilizing a healthy pyrimidine for DNA synthesis, then halts DNA replication due to malformation (also leads to RNA demise as well)

117
Q

Methotrexate (gen)

A

Antimetabolite (folate), Inhibit enzymes involved with folate synthesis to aid in DNA formation

118
Q

Alimta

A

Pemetrexid, Antimetabolite (folate), Inhibit enzymes involved with folate synthesis to aid in DNA formation

119
Q

Pralatrexate (gen)

A

Antimetabolite (folate), Inhibit enzymes involved with folate synthesis to aid in DNA formation

120
Q

Raltitrexed (gen)

A

Antimetabolite (folate), Inhibit enzymes involved with folate synthesis to aid in DNA formation

121
Q

Vidaza

A

Azacitidine, antimetabolite (other), DNA methylation inhibitor
Direct cellular toxicity at abnormal bone marrow cells

122
Q

Decogen

A

Decitabine, antimetabolite (other), DNA methylation inhibitor
Direct cellular toxicity at abnormal bone marrow cells

123
Q

Adriamycin

A

Doxorubucin, anthraxyxline, -Interchalates DNA

  • ROS
  • TOPO Isomerase 2 inhibitor ( alleviate tension in both strands in dna during replicaton) so with anthracycline, the cut DNA cannot re-ligate, so apotosis.
124
Q

Doxil

A

Liposomal doxorubucin, anthraxyxline, -Interchalates DNA

  • ROS
  • TOPO Isomerase 2 inhibitor ( alleviate tension in both strands in dna during replicaton) so with anthracycline, the cut DNA cannot re-ligate, so apotosis.
125
Q

Danorubucin (gen)

A

anthraxyxline, -Interchalates DNA

  • ROS
  • TOPO Isomerase 2 inhibitor ( alleviate tension in both strands in dna during replicaton) so with anthracycline, the cut DNA cannot re-ligate, so apotosis.
126
Q

Epirubicin (gen)

A

anthraxyxline, -Interchalates DNA

  • ROS
  • TOPO Isomerase 2 inhibitor ( alleviate tension in both strands in dna during replicaton) so with anthracycline, the cut DNA cannot re-ligate, so apotosis.
127
Q

Idarubicin (gen)

A

anthraxyxline, -Interchalates DNA

  • ROS
  • TOPO Isomerase 2 inhibitor ( alleviate tension in both strands in dna during replicaton) so with anthracycline, the cut DNA cannot re-ligate, so apotosis.
128
Q

Valrubicin (gen)

A

anthraxyxline, -Interchalates DNA

  • ROS
  • TOPO Isomerase 2 inhibitor ( alleviate tension in both strands in dna during replicaton) so with anthracycline, the cut DNA cannot re-ligate, so apotosis.
129
Q

Vincristine (gen)

A

Microtubule (Vinca Alkaloid), Bind to tubulin, a key factor in the assembly and disassembly of microtubules, arresting cell proliferation

130
Q

Vinblastine (gen)

A

Microtubule (Vinca Alkaloid), Bind to tubulin, a key factor in the assembly and disassembly of microtubules, arresting cell proliferation

131
Q

Vinorelbine (gen)

A

Microtubule (Vinca Alkaloid), Bind to tubulin, a key factor in the assembly and disassembly of microtubules, arresting cell proliferation

132
Q

Taxol

A

Paclitaxel, microtubule (taxane), Promotes assembly, disassembly, and stabilization of microtubule, arresting cell proliferation.

133
Q

Taxotere

A

Docetaxel, microtubule (taxane), Promotes assembly, disassembly, and stabilization of microtubule, arresting cell proliferation.

134
Q

Abraxane

A

Paclitaxel-protein bound, microtubule (taxane), Promotes assembly, disassembly, and stabilization of microtubule, arresting cell proliferation.

135
Q

Cabazitaxel (gen)

A

microtubule (taxane), Promotes assembly, disassembly, and stabilization of microtubule, arresting cell proliferation.

136
Q

Eribulin (gen)

A

Microtubule (other), Suppresses microtubule polymerization and inhibits spindle formation

137
Q

Ixabepilone (gen)

A

Microtubule (other), Suppresses microtubule polymerization and inhibits spindle formation

138
Q

Ado-trastuzumab (gen)

A

Her-2 antibody conjugate with antimicrotubule inhibitor

139
Q

Emtansine (gen)

A

Her-2 antibody conjugate with antimicrotubule inhibitor

140
Q

Camptosar

A

Irinotecan, topo I inhibitor, Inhibits topo I (stabilizing the cleaved DNA strand, preventing re-ligation)

141
Q

Hycamtin

A

Topotecan, topo I inhibitor, Inhibits topo I (stabilizing the cleaved DNA strand, preventing re-ligation)

142
Q

Anthracycline (gen)

A

Topo II inhibitor, Inhibits topo II (re-ligation)

Other MOAs too

143
Q

Toposar

A

Etoposide, Topo II inhibitor, Inhibits topo II (re-ligation)
Other MOAs too

144
Q

Teniposide (gen)

A

Topo II inhibitor, Inhibits topo II (re-ligation)

Other MOAs too

145
Q

Mitoxantrone (gen)

A

Topo II inhibitor, Inhibits topo II (re-ligation)

Other MOAs too

146
Q

Cytoxan

A

Cyclophosphamide, Alkylating agent (nitrogen mustard), Alkylate DNA, causing cross-linking, inducing strand breakage

147
Q

Iphosphamide (gen)

A

Alkylating agent (nitrogen mustard), Alkylate DNA, causing cross-linking, inducing strand breakage

148
Q

Bendamustine (gen)

A

Alkylating agent (nitrogen mustard), Alkylate DNA, causing cross-linking, inducing strand breakage

149
Q

Chlorambucil (gen)

A

Alkylating agent (nitrogen mustard), Alkylate DNA, causing cross-linking, inducing strand breakage

150
Q

Mechlorethamine (gen)

A

Alkylating agent (nitrogen mustard), Alkylate DNA, causing cross-linking, inducing strand breakage

151
Q

Melphalan (gen)

A

Alkylating agent (nitrogen mustard), Alkylate DNA, causing cross-linking, inducing strand breakage

152
Q

Carmustine (BCNU) (gen)

A

Alkylating agents (Triazense), Alkylate DNA at the O6, N7 position of guanine, causing cross-linking, inducing strand breakage

153
Q

Lomustine (gen)

A

Alkylating agents (Triazense), Alkylate DNA at the O6, N7 position of guanine, causing cross-linking, inducing strand breakage

154
Q

Streptozocin (gen)

A

Alkylating agents (Triazense), Alkylate DNA at the O6, N7 position of guanine, causing cross-linking, inducing strand breakage

155
Q

Matulane

A

Procarbazine (oral), alkylating agent (other), Inhibits transmethylation of methionine into tRNA; insight strand breakage

156
Q

Carboplatin (gen)

A 
Alkylating agents (platinums), Insights cross-linking
Violates the double-helix structure
Strand breakage
157
Q

Cisplatin (gen)

A 
Alkylating agents (platinums), Insights cross-linking
Violates the double-helix structure
Strand breakage
158
Q

Eloxitan

A

Oxaloplatin, Alkylating agents (platinums), Insights cross-linking
Violates the double-helix structure
Strand breakage

159
Q

Bleomycin (gen)

A

Antibiotic, Inhibits synthesis of DNA

And causes ROS

160
Q

Hydrea

A

Hydroxyurea (oral), Miscellaneous, Antimetabolite inhibiting ribonucleoside diphosphate reductase, preventing conversion of ribonucleotides to deoxyribonucleotides  halting cell cycle
Increases Hgb F levels

161
Q

Mitomycin-C (gen)

A

MIsc, Alkylating agent, creates cross-linking with guanine and cytosine pairs.

162
Q

Tarceda

A

Elotinib (oral), Anti-EGFR ORAL, EGFR selective TKI

163
Q

Tykerb

A

Lapatinib (oral), Anti-Her2 new agent ORAL, EGFR and HER 2 TKI

164
Q

Gleevac

A

IMatinib (oral), BCR-ABL, Inhibits TK activity of BCR-ABL Philadelphia chromosome in CML

165
Q

Dasatinib (gen)

A

BCR-ABL, Inhibits TK activity of BCR-ABL Philadelphia chromosome in CML

166
Q

Nilotinib (gen)

A

BCR-ABL, Inhibits TK activity of BCR-ABL Philadelphia chromosome in CML

167
Q

Bosutinib (gen)

A

BCR-ABL, Inhibits TK activity of BCR-ABL Philadelphia chromosome in CML

168
Q

Iclusig

A

Ponatinib (oral), BCR-ABL, Inhibits TK activity of BCR-ABL Philadelphia chromosome in CML

169
Q

Sutent

A

Sunitinib (oral), Kinase inhibitor, Inhibit multiple receptor TKs

170
Q

Nexavar

A

Soratenib (oral), Kinase inhibitor, Inhibit multiple receptor TKs

171
Q

Pazopanib (gen)

A

Kinase inhibitor, Inhibit multiple receptor TKs

172
Q

Azitinib (oral) (gen)

A

Kinase inhibitor, Inhibit multiple receptor TKs

173
Q

Rforafenib (gen)

A

Kinase inhibitor, Inhibit multiple receptor TKs

174
Q

Vandetanib (gen)

A

Kinase inhibitor, Inhibit multiple receptor TKs

175
Q

Valcade

A

Bortezomib, proteosome inhibitor, Inhibits proteasomes, critical for protein homeostasis, inducing apoptosis

176
Q

Kyprolis

A

Carfilzomib, proteosome inhibitor, Inhibits proteasomes, critical for protein homeostasis, inducing apoptosis

177
Q

Xalkori

A

Cicotinib (oral), misc oral, ALK inhibition, ALK is a down-stream mutation causing constant “on” of proliferation; used in NSCLC

178
Q

Zykadia

A

Ceritinib (oral), ALK inhibition, ALK is a down-stream mutation causing constant “on” of proliferation; used in NSCLC

179
Q

Jakafi

A

Ruxolitinib, misc oral, JAK1, JAK2 inhibition of the JAK-STAT signaling pathway. Used in myeloproliferative disorders with JAK2 mutations

180
Q

Rituxan

A

Rituximab, Anti-CD 20, Binds to CD20 on B cells, induces ADCC

181
Q

Azerra

A

Ofatumumab, Anti-CD 20, Binds to CD20 on B cells, induces ADCC

182
Q

Campath

A

Alemtuxumab, Anti-CD 52, Binds to CD 52 on B and T cells, inhibits interaction with other immune system functions, induces ADCC

183
Q

Adcetris

A

Brentuzimab Vedotin, Anti-CD 30, Binds to CD 30 and introduces Vedotin (microtubule poison)

184
Q

Erbitux

A

Cetuximab, EGFR, Bind to and inhibit extracellular EGFR, induces apoptosis

185
Q

Panitumumbab (gen)

A

EGFR, Bind to and inhibit extracellular EGFR, induces apoptosis

186
Q

Herceptin

A

Trastuzumab, HER 2, Binds to HER2 at different points on the receptor, induces ADCC

187
Q

Perjeta

A

Pertuzumab, HER 2, Binds to HER2 at different points on the receptor, induces ADCC

188
Q

Ado-Trastuzumab (gen)

A

HER 2, Binds to HER2 at different points on the receptor, induces ADCC

189
Q

Ematansine (gen)

A

HER 2, Binds to HER2 at different points on the receptor, induces ADCC

190
Q

Avastin

A

Bevacizumab, VEGF, Binds to circulating VEGF, inhibits the formation for vasculature, required for tumor growth

191
Q

Yervoy

A

Ipilimumab, CTLA-4, Binds to cytotoxic T-lymphocyte associated antigen 4 (CTLA-4), enhancing T-cell activation

192
Q

IL-2 (aldesleukin) (gen)

A

Interferon, Cytokine, promoting B and T cell proliferation, anti-cancer therapy based on tumor susceptibility to lymphokine-activated killer cells and tumor-infiltrating lymphocytes

Comprehensive Drug Review (1 decks)

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