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5. Anticoagulants > Brand-Generic/MOA & Drugs > Flashcards

Brand-Generic/MOA & Drugs Flashcards

1
Q

Novastan

  • MOA
  • Indication
  • Form
A

Argatroban

  • Direct thrombin inhibitor
  • HIT
  • F: IV
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2
Q

Angiomax

  • MOA
  • Form:
A

Bivalirudin

  • Direct thrombin inhibitor
  • F: IV
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3
Q

Iprivask

  • MOA:
  • Form:
  • Indication
  • CrCl adjustment
A

Desirudin

  • MOA: Direct thrombin inhibitor (DTI)
  • 15mg SQ Q12H
  • I: DVT ppx
  • CrCl
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4
Q

Pradaxa

  • MOA
  • Dose
    CrCl > 30
    CrCl 15-30
    CrCl
A

Dabigatran

  • MOA: Direct thrombin inhibitor (DTI
  • Dose: 150 mg BID
  • CrCl 15-30: 75mg BID
  • CrCl
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5
Q

Fragmin

  • MOA:
  • D/Route/Frequency
A

Dalteparin

  • MOA: LMWH => FXa Inhibitors
  • 2500-5000 units SC QD
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6
Q

Innohep

  • MOA:
  • Route/Frequency
A

Tinzaprin

  • MOA: LMWH => FXa Inhibitors
  • SC QD
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7
Q

Lovenox

  • MOA:
  • Route
A

Enoxaparin

  • MOA: LMWH => FXa Inhibitors
  • SC
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8
Q

Xarelto

  • MOA:
  • Indication
  • Dose
  • Administration instruction
A

Rivaroxaban

- MOA: FXa Inhibitors
Indication
- Prevention of stroke in a.fib
- DVT pxx in HIP/Knee replacement
- DVT or PE treatment
Dose
- PE/DVT tx: 15mg BID x 3wk then 20mg QD
- Take w/ food for dose 20mg
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9
Q

Arixtra

  • MOA:
  • Indication
A

Fondaparinux

  • MOA: FXa Inhibitors
    Indication
  • DVT pxx in HIP/Knee replacement
  • DVT or PE treatment
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10
Q

Coumadin

A

Warfarin

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11
Q

Eliquis

  • Indication:
  • Dose:
  • Surgery/Antidote:
A

Apixaban

Indication

  • Prevention of stroke in a.fib
  • DVT pxx in HIP/Knee replacement
  • DVT or PE treatment
  • D: 5mg PO BID
  • 2.5 mg PO BID in pts w/ 2 of the followings: age >/= 80 y, BW /= 1.5 mg/dL, on strong inhibitor of 3A4 & P-gp (keto/itratroconazole, ritonavir)
  • Surgery: d/c 48H prior of mod/high risk surgery; d/c 24H prior to low risk surgery
  • Antidote: no
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12
Q

Savaysa

  • Indication
A

Edoxaban

Indication

  • Prevention of stroke in a.fib
  • DVT pxx in HIP/Knee replacement
  • DVT or PE treatment
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13
Q

ReoPro

  • MOA:
A

Abciximab

  • MOA: block fibrinogen bind to GPIIb/IIIa receptor on platelet = prevents platelets from aggregrating together
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14
Q

Aggrastat

  • MOA:
A

Tirofiban

  • MOA: block fibrinogen bind to GPIIb/IIIa receptor on platelet = prevents platelets from aggregrating together
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15
Q

Integrilin

  • MOA:
A

Eptifibatide

  • MOA: block fibrinogen bind to GPIIb/IIIa receptor on platelet = prevents platelets from aggregrating together
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16
Q

Pletal

  • MOA:
  • Indication
A

Cilostazole

  • MOA: ADP receptor antagonist (thienopyridines)
  • I: Claudication
17
Q

Ticlid

  • MOA:
A

Ticlopidine

  • MOA: ADP receptor antagonist
18
Q

Plavix

  • MOA:
A

Clopidogrel

  • MOA: ADP receptor antagonist
19
Q

Effient

  • MOA:
A

Prasugrel

  • MOA: ADP receptor antagonist
20
Q

Brilinta

  • MOA:
A

Ticagrelor

  • MOA: ADP receptor antagonist
21
Q

Persantine

  • MOA:
A

Dipyridamole

MOA: Reversible inhibitors of platelet aggregation: inc cAMP in platelets

22
Q

ASA + Dipyridamole

  • Dose
A

Aggrenox

- Dose: 1 cap BID

23
Q

Activase

-MOA:

A

Alteplase (tPA)

-MOA: Thrombolytic agent: Direct activates plasminogen to form plasmin which leads to clot lysis.

24
Q

Retavase

-MOA:

A

Reteplase (rPA)

-MOA: Thrombolytic agent: Direct activates plasminogen to form plasmin which leads to clot lysis.

25
Q

Strepase

-MOA:

A

Streptokinase (SK)

-MOA: Thrombolytic agent: Direct activates plasminogen to form plasmin which leads to clot lysis.

26
Q

TNKase

-MOA:

A

Tenecteplase (TNK-tPA)

-MOA: Thrombolytic agent: Direct activates plasminogen to form plasmin which leads to clot lysis.

27
Q

Abbokinase

-MOA:

A

Urokinase

-MOA: Thrombolytic agent: Direct activates plasminogen to form plasmin which leads to clot lysis.

28
Q

List anticoagulants that is given PO

A
  1. Rivaroxaban (Xarelto) - 10 mg QD
    - FXa inhibitor
  2. Warfarin (Coumadin) - 2-10 mg QD
    - Vit K antagonist. Only 1 requires monitor
  3. Dabigatran (Pradaxa) - 150 mg BID
    - Direct thrombin inhibitor => reversible
  4. Apixaban (Eliquis) - 5 mg BID
  5. Edoxaban (Lexiana)
29
Q

Zontivity

  • MOA
  • Indication
A

Vorapaxar

  • MOA: inhibits protease activated receptor-1
  • Indications: Prevention of thrombotic events post MI in pt with PAD with ASA or Clopidogrel

5. Anticoagulants (9 decks)

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