Brand/Generic/Indications Flashcards
Leuprolide
-Lupron
-GnRH/LHRH agonists
-Initially increase follicle stimulating hormone (FSH) and luteinizing hormone (LH) release, followed by suppression due to desensitization of pituitary gonadotropin-releasing hormone
Goserelin
-Zoladex
-GnRH/LHRH agonists
-Initially increase follicle stimulating hormone (FSH) and luteinizing hormone (LH) release, followed by suppression due to desensitization of pituitary gonadotropin-releasing hormone
Abiraterone acetate
-Zytiga®
-Inhibits 17alpha-hydroxylase = CYP 17A1, which inhibits steroid hormone production
that would stimulate hormone-responsive
prostate cancer cells
Anastrazole
-Arimidex®
-Inhibit aromatase = CYP 19A1, which inhibits estrogen production that would stimulate hormone-responsive breast cancer
cells
Letrozole
-Femara®
-Inhibit aromatase = CYP 19A1, which inhibits estrogen production that would stimulate hormone-responsive breast cancer cells
Tamoxifen
-Nolvadex®
-Selective Estrogen Receptor Modulators (SERMs)
-requires metabolic activation to endoxifen – activity is tissue dependent – acts as an ER
antagonist in breast cancer
Raloxifene
-Evista®
-Selective Estrogen Receptor Modulators (SERMs)
-use: breast cancer prevention and for osteoporosis in postmenopausal women
Fulvestrant
-Faslodex®
-Estrogen Receptor Antagonists
- metastatic breast cancer
Toremifene
-Fareston®
-Estrogen Receptor Antagonists
- metastatic breast cancer (postmenopausal)
Megestrol acetate
-Megace®
-Estrogen Receptor Antagonists
-progestin - decrease estradiol production - Use: treatment of breast, endometrial, and renal cell cancers
Enzalutamide
-Xtandi
-Androgen Receptor Antagonists
-potent androgen receptor antagonist used for treatment of advanced, castration-resistant prostate cancer
-Bicalutamide (Casodex®) but Xtandi is better!
Sipuleucel-T
-Provenge®
-Cells are cultured ex vivo together with a fusion protein (PAP–GM-CSF), composed of prostate acid phosphatase (PAP), which is specifically expressed by prostatic cells; and granulocyte– macrophage colony-stimulating factor (GM–CSF), which enhances immune responses.
erythropoiesis stimulating agents (ESAs)
-Epoetin alfa & darbepoetin
-for anemia (myelosupp)
Neupogen
-filgrastim
-G-CSF
-prevent or reduce neutropenia
tbo-filgrastim
-Granix
-G-CSF
-prevent or reduce neutropenia
filgrastim-sndz
-Zarxio
-Biosimilar
-G-CSF
-prevent or reduce neutropenia
filgrastim-aafi
-Nivestym
-Biosimilar
-G-CSF
-prevent or reduce neutropenia
filgrastim-ayow
-Releuko
-Biosimilar
-G-CSF
-prevent or reduce neutropenia
Pegfilgrastim
-Neulasta
-Pegylated G-CSF
-prevent or reduce neutropenia
Pegylated G-CSF Biosimilars
- pegfilgrastim-jmbd(Fulphila)
- pegfilgrastim-cbqv(Udenyca)
- pegfilgrastim-pbbk (Fylnetra)
- pegfilgrastim-apgf(Nyvepria)
- pegfilgrastim-fpgk (Stimufend)
- pegfilgrastim-bmez(Ziextenzo)
Granisetron
-Kytril
-5HT3 RAs
-N/V
Palonosetron
-Aloxi
-5HT3 RAs
-N/V
Aprepitant
-Emend
-NK1 RAs
-N/V
-CYP3A4 Inhibitor (interaction with dexamethasone, decrease dexamethasone dose)
Fosaprepitant
-Emend for Injection
-NK1 RAs
-N/V
-CYP3A4 Inhibitor (interaction with dexamethasone, decrease dexamethasone dose)
