Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

IP Oncology Exam 2 > Brand/Generic/Indications > Flashcards

Brand/Generic/Indications Flashcards

1
Q

Leuprolide

A

-Lupron
-GnRH/LHRH agonists
-Initially increase follicle stimulating hormone (FSH) and luteinizing hormone (LH) release, followed by suppression due to desensitization of pituitary gonadotropin-releasing hormone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Goserelin

A

-Zoladex
-GnRH/LHRH agonists
-Initially increase follicle stimulating hormone (FSH) and luteinizing hormone (LH) release, followed by suppression due to desensitization of pituitary gonadotropin-releasing hormone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Abiraterone acetate

A

-Zytiga®
-Inhibits 17alpha-hydroxylase = CYP 17A1, which inhibits steroid hormone production
that would stimulate hormone-responsive
prostate cancer cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Anastrazole

A

-Arimidex®
-Inhibit aromatase = CYP 19A1, which inhibits estrogen production that would stimulate hormone-responsive breast cancer
cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Letrozole

A

-Femara®
-Inhibit aromatase = CYP 19A1, which inhibits estrogen production that would stimulate hormone-responsive breast cancer cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Tamoxifen

A

-Nolvadex®
-Selective Estrogen Receptor Modulators (SERMs)
-requires metabolic activation to endoxifen – activity is tissue dependent – acts as an ER
antagonist in breast cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Raloxifene

A

-Evista®
-Selective Estrogen Receptor Modulators (SERMs)
-use: breast cancer prevention and for osteoporosis in postmenopausal women

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Fulvestrant

A

-Faslodex®
-Estrogen Receptor Antagonists
- metastatic breast cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Toremifene

A

-Fareston®
-Estrogen Receptor Antagonists
- metastatic breast cancer (postmenopausal)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Megestrol acetate

A

-Megace®
-Estrogen Receptor Antagonists
-progestin - decrease estradiol production - Use: treatment of breast, endometrial, and renal cell cancers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Enzalutamide

A

-Xtandi
-Androgen Receptor Antagonists
-potent androgen receptor antagonist used for treatment of advanced, castration-resistant prostate cancer
-Bicalutamide (Casodex®) but Xtandi is better!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Sipuleucel-T

A

-Provenge®
-Cells are cultured ex vivo together with a fusion protein (PAP–GM-CSF), composed of prostate acid phosphatase (PAP), which is specifically expressed by prostatic cells; and granulocyte– macrophage colony-stimulating factor (GM–CSF), which enhances immune responses.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

erythropoiesis stimulating agents (ESAs)

A

-Epoetin alfa & darbepoetin
-for anemia (myelosupp)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Neupogen

A

-filgrastim
-G-CSF
-prevent or reduce neutropenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

tbo-filgrastim

A

-Granix
-G-CSF
-prevent or reduce neutropenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

filgrastim-sndz

A

-Zarxio
-Biosimilar
-G-CSF
-prevent or reduce neutropenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

filgrastim-aafi

A

-Nivestym
-Biosimilar
-G-CSF
-prevent or reduce neutropenia

18
Q

filgrastim-ayow

A

-Releuko
-Biosimilar
-G-CSF
-prevent or reduce neutropenia

19
Q

Pegfilgrastim

A

-Neulasta
-Pegylated G-CSF
-prevent or reduce neutropenia

20
Q

Pegylated G-CSF Biosimilars

A
  • pegfilgrastim-jmbd(Fulphila)
  • pegfilgrastim-cbqv(Udenyca)
  • pegfilgrastim-pbbk (Fylnetra)
  • pegfilgrastim-apgf(Nyvepria)
  • pegfilgrastim-fpgk (Stimufend)
  • pegfilgrastim-bmez(Ziextenzo)
21
Q

Granisetron

A

-Kytril
-5HT3 RAs
-N/V

22
Q

Palonosetron

A

-Aloxi
-5HT3 RAs
-N/V

23
Q

Aprepitant

A

-Emend
-NK1 RAs
-N/V
-CYP3A4 Inhibitor (interaction with dexamethasone, decrease dexamethasone dose)

24
Q

Fosaprepitant

A

-Emend for Injection
-NK1 RAs
-N/V
-CYP3A4 Inhibitor (interaction with dexamethasone, decrease dexamethasone dose)

25
Q

Alternative agents for CINV

A
26
Q

Trastuzumab

A

-Herceptin
-Breast cancer: HER2 targeted agents

27
Q

Pertuzumab

A

-Perjeta
-Breast cancer: HER2 targeted agents

28
Q

Phesgo

A

Pertuzumab + Trastuzumab combo

29
Q

Ado-trastuzumab emtansine

A

-Kadcyla
-HER2 targeted agents: ADC

30
Q

Exemestane

A

Aromatase Inhibitors (AI)

31
Q

Palbociblib

A

-Ibrance
-CDK 4/6 inhibitors

32
Q

Ribociclib

A

-Verzenio
-CDK 4/6 inhibitors

33
Q

Abemeciclib

A

-Kisqali
-CDK 4/6 inhibitors

34
Q

Olaparib

A

-Lynparza (breast and ovarian)
-PARP inh

35
Q

Talazoparib

A

-Talzenna (breast)
-PARP inh

36
Q

PARP inhibitors in ovarian cancer

A

Olaparib (Lynparza)
Niraparib (Zejula)
Rucaparib (Rubraca)

37
Q

Bevacizumab

A

Avastin
-Vascular Endothelial Growth Factor (VEGF) inhibitor
-many biosimilar

38
Q

Anti-EGFR Monoclonal Antibodies for colon cancer

A

Cetuximab and Panitumumab

39
Q

VEGF monoclonal antibody for colon cancer

A

Bevacizumab and Ramucirumab

40
Q

PD-1 Monoclonal Antibodies for colon cancer

A

Pembrolizumab, Nivolumab, Dostarlimab-gxly

IP Oncology Exam 2 (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions