Brainstem Anatomy Flashcards

1
Q

What is the function of the brainstem?

A
  • performs spinal cord-like functions for the regions of the head and neck
  • contains vital centres for the control of:
  • cardiorespiratory function
  • posture and movement
  • wakefulness and sleep
  • is the conduit (channel) for important tracts:
    –> ascending sensory tracts from the spinal cord
    –> descending motor tracts from the forebrain (telencephalon + diencephalon)
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2
Q

What are the components of the brainstem?

A

Midbrain, pons and medulla oblongata

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3
Q

What are the external features of the ventral (anterior) brainstem?

A

Pyramids, base of pons (basis pontis) and cerebral peduncles.

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4
Q

Describe the pyramids of the ventral (anterior) surface of the brainstem.

A

The pyramids are 2 white columns that form the medulla oblongata ventromedially.

i. Formed by a bundle of axon fibres called the corticospinal tract, which transmit information from the cerebral cortex –> spinal cord
ii. Pyramidal decussation: junction of the medulla and spinal cord, 90% of fibres from each pyramid cross the midline to enter the opposite side of the spinal cord
iii. Ventral median sulcus: separate the pyramids
iv. Olives: 2 large swelling visible lateral to the pyramids in the upper (rostral) part of the medulla

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5
Q

Describe the base of pons on the ventral surface of the brainstem.

A

Forms the ventral surface of the pons, with the basilar groove in the midline (occupied by the basilar artery.

i. Middle cerebellar peduncle (MCP): extension of the base of the pons laterally on each side that enters the cerebellum
1) Largest cranial nerve CN5 arises from the MCP
2) Is the largest of the 3 cerebellar peduncles

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6
Q

Describe the cerebral peduncles on the ventral surface of the brainstem.

A

The cerebral peduncles are 2 massive white structures that forms the ventral surface of the midbrain.
i. Interpeduncular fossa: separates the 2 cerebral peduncles.

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7
Q

What are the 4 key landmarks on the dorsal (posterior) surface of the brainstem.

A

Gracile fasciculus + cuneate fasciculus, fourth ventricle, isthmus and superior + inferior colliculi.

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8
Q

How does the fourth ventricle form in the brainstem?

A

In the more rostral medulla, the gracile and cuneate fasciculi gradually disappear as the central canal opens out to form the fourth ventricle.

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9
Q

Outline the gracile and cuneate fasciculus.

A

These are 2 paired white columns that form the dorsal surface of the medulla.
i. Function: carry somatosensory information from the limbs and trunk.
1) Gracile: lower limb and trunk
2) Cuneate: upper limb and trunk

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10
Q

What is the exact location of the 4th ventricle?

A

Between the cerebellum behind and the medulla and pons in front.

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11
Q

What is the rhomboid fossa and what are its key features?

A

The rhomboid fossa is the floor of the 4th ventricle. Its key features are:

1) Median fissure (in the midline)
2) Sulcus limitans: structure lateral to the median eminences, which is a foetal remnant separating basal plate (motor) from alar plate (sensory) derivatives.
3) Medial eminences: elevation between the median fissure and sulcus limitans (region for motor neuron)
4) Vestibular + acoustic area: area lateral to the sulcus limitans (region for sensory neuron)
5) Roof: superior and inferior medullary vela
6) Lateral boundaries:
a) Cuneate tubercle
b) ICP
c) SCP

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12
Q

What is the isthmus?

A

Junction between pons and midbrain.

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13
Q

What are the superior and inferior colliculi?

A

Paired structures forming the dorsal surface of the midbrain (collectively referred to as the tectum)

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14
Q

What are the 2 key internal features of the brainstem?

A

Tegmentum and Ascending/Descending tracts

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15
Q

Outline the tegmentum (internal feature of brainstem).

A

The tegmentum is the central core of the brain stem located between the ventricles and the basal part of the brainstem.

It contains:
1) Reticular formation: structure containing various nuclei + numerous ascending and descending tracts
2) Cranial nerves nuclei:
a) Only thing to know here is the prominent spinal nucleus of the trigeminal nerve, which replaces the dorsal horn of the spinal cord and extends throughout the medulla.

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16
Q

What are the 3 ascending/descending tracts?

A

1) Corticospinal tract
2) Medial lemniscus
3) Spinothalamic tract

17
Q

Describe the corticospinal tract.

A

Largest tract. Output from primary motor cortex (descending tract)

1) Function: fine, voluntary motor control
2) Cells of origin: primary motor cortex (precentral gyrus)
3) Pathway:
a. Precentral gyrus
b. Base of cerebral peduncle (midbrain) - middle 1/3
c. Base of pons
d. Pyramid of medulla
e. 85% of fibres cross in pyramidal decussation at the lower end of medulla. 10-15% stay on the same side.
f. The crossed tract form the lateral corticospinal tract.
g. Terminate/synapse at the ventral horn of spinal matter on spinal motor neurons.

18
Q

Describe the medial lemniscus.

A

The medial lemniscus is an input into the primary somatosensory cortex (ascending tract). It is the second part (second-order neuron) of ascending somatosensory pathway to the primary somatosensory cortex.

Its function is to transmit discriminative touch, proprioception and sense of vibration.

19
Q

What are the cells of origin of the medial lemniscus?

A

Gracile and cuneate nuclei (contralateral side)

20
Q

Outline the pathway of the medial lemniscus.

A

a. First-order neurons arises from the dorsat root ganglion (first part of ascending somatosensory pathway)
b. First-order neurons synapses with the second-order neurons a the gracile or cuneate nucleus
c. The axons of the second-order neurons (internal arcuate fibres) run anteromedially and cross at the level of the obex (sensory decussation) the midline of the midbrain to the contralateral side
d. After decussation, the internal arcuate fibres form the medial lemniscus which ascends towards the ventral posterolateral nucleus of the thalamus where it terminates/synapses.
e. Third-order neuron projects onwards to the primary somatosensory cortex.

21
Q

Describe key features of the spinothalamic tract.

A

Input to primary somatosensory cortex (ascending tract). Second part (second-order neuron) of the ascending somatosensory pathway to the primary somatosensory cortex.

Its function is to transmit pain, temperature and light touch.

22
Q

What are the cells of origin of the spinothalamic tract?

A

Dorsal horn (contralateral side)

23
Q

What is the pathway of the spinothalamic tract?

A

a. First-order neuron (blue) arises from the dorsal root ganglion ascend or descend 1-2 vertebral levels, then synapses in the dorsal horn with the second-order neurons (usually ascend)
b. Second-order neuron (green) decussate/cross over to the other side of the spinal cord
c. The axons travel up the length of the spinal cord to terminate in the thalamus (reticular formation)

24
Q

What is the gracile and cuneate nuclei?

A

Located on the caudal half of the medulla.

Function is to receive somatosensory information from the gracile and cuneate fasciculi and their axons cross the midline to form a tract called the medial lemniscus, which ascends to the thalamus.

25
Q

What is the inferior olivary nuclei?

A

Large, prominent in rostral medulla, forms swellings on the surface called olives; associated with cerebellum.

26
Q

What is the pontine nuclei?

A

Scattered masses of grey matter throughout the base of the pons. Their axons cross the midline and form the middle cerebellar peduncles as they enter the cerebellum.

27
Q

What is the location and function of the Spinal trigeminal nucleus (SP5N)?

A

Location: continuation of the dorsal horn
Function: receives somatosensory information of pain and temperature from the head

28
Q

What are the superior and inferior colliculi?

A

Found in the dorsal part of the midbrain - involved in visual (superior colliculus) and auditory (inferior colliculus) reflex activity.

29
Q

What is the periaqueductal grey?

A

Surrounds cerebral aqueduct (midbrain) - regulates pain transmission, also involved in autonomic control and defensive behaviour.

30
Q

What is the location and function of the red nucleus?

A

Location: rostral part of the midbrain, just above the cerebellar peduncle.
Function: Motor control of the upper body.

31
Q

Why is the substantia nigra stained black?

A

Due to a pigment called neuromelanin, a byproduct of dopamine.

32
Q

What is the hypoglossal nucleus, and what is its function and location?

A

The hypoglossal nucleus is a prominent cluster of large motor neurons.

Location: extends from the caudal pole of the 4th ventricle to the pyramidal decussation.
Function: supply the muscles of the tongue