Brain Tumours Flashcards

1
Q

Symptoms of space occupying lesion (SOL)

A

Progressive focal neurological deficit

Headache (worse in morning/straining)

Seizures

Papilloedema

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2
Q

Primary tumours which metastasise to brain

A
Lung
Breast
Kidney
Skin (melanoma)
Colon
(common cancers)
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3
Q

Symptoms of a brain tumour in the frontal lobe.

A

Weakness

Expressive dysphasia Personality change

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4
Q

Symptoms of a brain tumour in the parietal lobe.

A

Sensory loss
Neglect
Loss of spatial awareness
Loss of reading and writing ability

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5
Q

Symptoms of a brain tumour in the temporal lobe

A

Hearing loss
Receptive dysphasia
Memory loss

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6
Q

Symptoms of a brain tumour in the occipital lobe

A

Visual loss

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7
Q

Symptoms of a brain tumour in the cerebellum.

A

Dizziness
Nausea
Ataxia

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8
Q

What is the investigation of choice for a suspected brain tumour?

A

MRI

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9
Q

What brain tumours most commonly affect adults?

5

A
Astrocytoma
Meningioma
Oligodendroglioma
Schwannoma
Pituitary adenoma
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10
Q

What brain tumours most commonly affect children?

A

Astrocytoma
Medulloblastoma
Craniopharyngioma

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11
Q

What is the most common brain tumour in adults?

A

Astrocytoma

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12
Q

What is the second most common brain tumour in adults?

A

Meningioma

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13
Q

What is the most common brain tumour in children?

A

Astrocytoma

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14
Q

What is the second most common brain tumour in children?

A

Medullablastoma

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15
Q

What are the names of the 4 graded astrocytic tumours?

A

Grade I: pilocytic astrocytoma

Grade II: diffuse astrocytoma

Grade III: anaplastic astrocytoma

Grade IV: glioblastoma multiforme

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16
Q

Truly benign astocytoma?

A

Pilocytic astrocytoma

17
Q

What are pilocytic astrocytomas composed of?

A
Hair like tissue (pilo_)
Cystic areas (_cysic)
18
Q

Who tends to develop pilocytic astrocytoma?

A

Children

19
Q

Brain tumour commonly presenting with a seizure?

A

Diffuse astrocytoma (grade II)

may also be oligodendroglioma, but less common

20
Q

Tumour enhances on contrast study.

What does this suggest?

A

Malignant

21
Q

What do anaplastic astrocytoma commonly progress to?

A

Glioblastoma multiforme

22
Q

What is the commonest primary brain tumour?

A

Glioblastoma multiforme

23
Q

What do glioblastoma multiforme show histologically?

A

Severe atypia and areas of necrosis and neovascularisation

24
Q

What are the two types of glioblastoma multiforme and how do they differ

A

Primary: arise de novo

Secondary: arise from transformation from anaplastic astrosytoma

They are molecularly different

25
Q

Neurofibromatosis type 2 is associated with which brain tumour?

A

Meningioma

Vestibular schwannoma

26
Q

Elderly man with café au lait marks is

  • symptomatic
  • asymptomatic

What brain tumours is he likely to have for each answer?

What symptoms would he have if he is asymptomatic?

A

Symptomatic: vestibular schwannoma (sensorineural hearing loss, vertigo)

Asymptomatic: meningioma

27
Q

How do you treat meningioma?

A

Conservatively if asymptomatic

If symptoms, excise

28
Q

Which brain tumour carries the best prognosis?

Do they tend to affect children or adults?

A

Oligodendroglioma

Adults

29
Q

What tumour can mimic astrocytoma?

A

Oligodendroglioma

30
Q

How do you manage vestibular schwannoma?

A

Periodic neurological examination/MRI
+
Hearing aid

31
Q

Where do adult brain tumours generally arise?

A

Above the tentorium cerebelli

32
Q

Tumour in midline of cerebellum.

Diagnosis?
Child or adult?

A

Medulloblastoma

Child

33
Q

What do medulloblastomas appear like histologically?

A

Embryonic precursor cells

blast

34
Q

Child presents with bitemporal hemianopia.

Diagnosis?

A

Craniopharyngioma

35
Q

Where do adult brain tumours generally arise?

A

Below tentorium cerebelli

36
Q

What is epenyoma?

A

Tumour of ependymal cells (lining of ventricles) which presents in the brain in children and in the spinal cord in adults

37
Q

What is haemangioblastoma?

A

CNS tumour which arises from the vasculature and has endothelial cells in it

38
Q

Midline tumour in a child with mixed cytology.

Diagnosis?
First step in management?

A

Pineal tumour

Blood test for blood markers
AFP, b-HCG, PLAP

39
Q

Midline tumour in child with high

  • AFP
  • b-HCG
  • PLAP.

Diagnosis for each?

A

AFP: yolk sac tumour

b-HCG: choriocarcinoma

PLAP: germinoma