Brain Tumors of Adults

Question 1

What are the Grade 1 tumors? (3)

Answer 1

Hemangioblastoma
Classic meningioma
Schwannoma

Question 2

What are the Grade 2 tumors (4)

Answer 2

Diffuse Astrocytoma
Atypical/Clear cell Meningioma
Oligodendroglioma
Central Neurocytoma

Question 3

What are the Grade 3 tumors (3)

Answer 3

Anaplastic Glioma
Gliomatosis Cerebri
Papillary/Anaplastic Meningioma

Question 4

What are the Grade 4 tumors (2)

Answer 4

Glioblastoma Multiforme

Gliosarcoma

Question 5

Which decade do diffuse astrocytomas occur?

Answer 5

Third

Question 6

Where do diffuse astrocytomas occur?

Answer 6

Cortex

Question 7

What is the main mutation of diffuse astrocytoma?

Answer 7

p53 on 17p

Question 8

What is the gross appearance of diffuse astrocytoma?

Answer 8

Poorly defined borders with calcifications and cysts. NO necrosis and hemorrhage

Question 9

What is the histology of diffuse astrocytoma?

Answer 9

Well differentiated homogenous gemistocytes (for gemistocytic astrocytoma -round fat cells)

Question 10

What is the marker for diffuse astrocytoma?

Answer 10

GFAP

Question 11

Do diffuse astrocytomas recur?

Answer 11

YES they always recur, often progressing to anaplastic astrocytomas

Question 12

What decade do anaplastic gliomas (#1 intracranial tumor) occur?

Answer 12

40’s

Question 13

Where do anaplastic gliomas occur?

Answer 13

cortical (esp. fronto-temporal)

Question 14

Common mutations for anaplastic gliomas?

Answer 14

p53 mutations, p16 deletions, RB mutations, and loss of heterozygosity at 19q.

Question 15

What is the gross appearance of anaplastic glioma?

Answer 15

Poorly defined mass with yellow necrosis

Question 16

What is the histological appearance of anaplastic glioma?

Answer 16

Anaplastic cells of varying size in a fibrillar/spiderweb background

Question 17

What is the marker for anaplastic glioma?

Answer 17

GFAP

Question 18

What is the main CT find of anaplastic glioma?

Answer 18

ring enhancement on CT