Brain Flashcards

(83 cards)

1
Q

Central Nervous System (CNS)

A

Everything inside the spine and skull

cortex, subcortical structures and nuclei, spinal cord

all encased in bone

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2
Q

Peripheral Nervous System (PNS)

A

everything outside of the spine and skull

Nerves- bundles of axons connecting CNS to body

Ganglion- clusters of cells associated with nerves

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3
Q

PNS system

A

Has inputs that arrive (Afferent)

Has outputs that exit (Efferent)

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4
Q

Peripheral Motor Output System (Efferent)

A

Somatic- controls voluntary movement

Autonomic- controls involuntary unconscious movements, has two components

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5
Q

Somatic motor system (efferent)

A

peripheral nerves exit the spinal cords and contact muscles

stimulation of nerves cause contraction of muscles

controls voluntary movement

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6
Q

Autonomic (efferent)

A

controls the lungs, heart, smooth muscles and endo and exocrine glands

two autonomic systems work together to to keep system balance

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7
Q

Sympathetic v parasympathetic

A

Complex system with many functions

Parasympathetic- rest and digest

Sympathetic- fight or flight

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8
Q

Sensory (afferent)

A

5 basic sensory systems (aware)-

Visual
Auditory
Olfactory (smell)
Gustatory (taste)
Tactile sensation (touch)

Not aware-

Vestibular (sense of head movement in space)
Proprioceptive (sensations from the muscles and joints of the body)

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9
Q

Movements as a circuit

A

All movements start in the sensory domain from a sensory input

Movements are- in response to an external stimuli (saving penalty)

Directed at an external stimulus (taking penalty)

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10
Q

2 major cell types

A

Neurones- electrically excitable
cell

communicate
with other cells via
specialized connections
called synapses.

Glial cells-non-neuronal cells in the
nervous system

maintain homeostasis,
form myelin, and
support and protect for
neurones.

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11
Q

Neurone

A

send and receive signals from your brain.

A cell body, which contains the nucleus and the cytoplasm

An axon, which transmits information away from the nucleus

Dendrites, which receive messages from other neurons.

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12
Q

Information passed through neurones

A

information passes from the cell body to
the axon terminals via an electrical
signal called an action potential

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13
Q

glia/ glial cells

A

5 major types of glial cells-

schwann cells
oligodendrocyte
microglial cell
ependymal cells
astrocyte

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14
Q

astrocytes- managing the brain environment

A
  1. regulates chemicals around neurones (glucose, ion concentrations, neurotransmitter uptake)

regulate blood flow around the brain

nervous system repair- fill in spaces creating glial scars

maintenance of the blood brain barrier.

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15
Q

Oligodendrocytes

A

form the myelin sheath on axons

Myelin- a fatty protein rich sheath that wraps around axons

1 can myelinate 50 axons

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16
Q

Schwann cells

A

form myelin in PNS

assist in regeneration/ regrowth of axons

myelin increases speed

unmyelinated speeds-0.5-10m/s- slow

myelinated speeds-up to 150m/s

creates initial pain/reaction and then secondary worse pain.

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17
Q

microglia

A

the brains immune system

scavenge the CNS for plaques, damaged cells and infectious agents

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18
Q

ependymal cells

A

make up the membrane called ependyma

membrane lines central canal of the spinal cord and ventricles

produces cerebrospinal fluid

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18
Q

Summary of cells in the nervous system

A

CNS-
neurones
microglia
astrocytes
ependymal
oligodendrocytes

PNS-
neurones
satellite
schwann

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19
Q

grey v white matter

A

myelin is a sheath that insulates many neurones

it is made of fat and proteins and is white

because of this parts of the brain that are many made up of axons are white (white matter).

the brains contains mainly the cell bodies of the neurones - nuclei, ganglion,
cortex - appear pink in the fresh tissue, but grey in perfused
(grey matter).

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20
Q

basic layout of the motor system

A
  1. spinal cord
  2. medulla
  3. pons
  4. cerebellum
  5. midbrain
  6. thalamus
  7. basal ganglia
  8. cerebral cortex
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21
Q

Brainstem``

A

sits at the top of the spinal cord

made of 3 parts-
medulla
pons
cerebellum``

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22
Q

medulla

A

the lower half of the brainstem

controls very basic motor functions

cardiac- central chemoreceptors sense oxygen levels- adjust heart rate/ blood pressure

respiration- chemoreceptors sense change in blood chemistry- increase breathing rate

reflexes- vomiting’s, coughing, sneezing and swallowing

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23
Q

`pons

A

contains nuclei that relay signals from forebrain to the cerebellum

nuclei that deal primarily with sleep, respiration, swallowing, bladder control, hearing, equilibrium, taste, eye movement, facial expressions, facial sensation and posture

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24
cerebellum
maintenance of balance and posture coordination of movements- especially across joints motor learning
25
midbrain
tectum controls rapid orientation of the head and neck- superior colliculus- vision inferior colliculus- sound substantia nigra- Parkinson's disease associated with sleep, wake cycles, alertness, temp regulation
26
thalamus
acts as a switchboard takes information from PNS and passes to cortex NB- hypothalamus hormones metabolic control e.g. hunger, body temp
27
cerebral cortex
it plays a key role in: * movement * attention * perception * awareness * thought * memory * language * consciousness
27
basal ganglia
* a series of interconnected nuclei * movement regulation * skill learning * habit formation * reward systems * selection of appropriate behaviours * self-initiation of behaviours
28
Spinal cord
Pathways to and from the brain
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Cell and white matter in the spinal cord
the middle of the cord (that looks a bit like an H) is made up of neurones and other cells (grey matter). outside cord- made up of fibres (white matter) carry information up and down the cord.
30
sensory information
touch proprioception vibration pain temperature sensory information enters the spinal cord at the dorsal horn
31
Motor neurones
located in the ventral spinal cord the neurones make direct contact onto muscles stimulation causes movement each cell is part of a motor unit
32
Muscles are controlled by a “motor pool” of Neurones
all motor neurones that innervate a single muscle are called a motor pool more muscle fibres than neurones so each fibre is innervated by a single neurone but one neurone may innervate many fibres The size of this innervation is important as muscles that are capable of fine movements are innervated by more neurones.
32
somatotopy
Maps are referred to as ‘somatotopic’ when that space is related to locations on the body, such that adjacent neurons in the neural tissue respond selectively to stimuli presented to adjacent locations on the body.
32
Spinal White Matter
fibre tracts that carry information to and from the brain
33
Lateral descending system
The corticospinal and rubrospinal tracts
34
Medial descending system
The vestibulospinal and reticulospinal tracts
35
Lateral descending system
The corticospinal and rubrospinal tracts make up the the lateral descending system * fibres of the lateral system are in the dorso- lateral part of the spinal cord. * they connect to motor neurones in the lateral part of the ventral horn. * this system influences lateral musculature.
36
lateral system – round up
Corticospinal fibers strongly influence movement of every part of the body and is particularly useful for individual finger use. 2. Other descending fibers, primarily the rubrospinal tract, can compensate almost completely for the loss of descending corticospinal input. 3. The one ability of the descending corticospinal tract for which no other tract can compensate is the ability to use the fingers individually. Individual finger movements are the sole province of the corticospinal system.
37
Medial system (vestibulospinal and reticulospinal tracts)
The vestibulospinal and reticulospinal tracts make up the the medial descending system. * fibres of the medial system are in the ventro-medial part white matter. * they connect to motor neurones in the medial part of the ventral horn. * this system influences medial musculature.
38
medial systems – round up
1. the medial systems are involved in the control of balance and posture. 2. these functions happen with little conscious control. 3. the vestibulospinal tract retains balance when the body is moved – external disturbance. 4. the reticulospinal tract helps us retain posture and balance during our own volitional movements – internal disturbance.
39
dorsal column pathway
carries sensory information from the joint and skin about: * fine touch. * vibration. * two-point discrimination. * proprioception (position) from the skin and joints.
40
Spinothalamic pathway
The lateral spinothalamic tract conveys * crude touch. * a sense of being touched without knowledge of where. * pain. * temperature.
40
Nerves
Regardless of where the cell bodies are, both the sensory and motor axons run in the same nerves. * These nerves are spinal nerves.
41
Information in and out of the spinal cord
The cell bodies of incoming sensory neurones lie outside the spine in a series of ganglion – called the Dorsal Root Ganglion (DRG) This is unlike the motor neurones that have their cell bodies in the ventral horn.
41
spinal nerves
* There are 31 pairs of spinal nerves. * The positions in the spine these nerves will determine what part of the body each spinal nerve serves. * Because some parts of the body have more muscles and more sensory receptors. The size of the nerve and the amount of information carried by the nerve will be different.
42
Dermatomes
an area of the skin supplied by nerves from a single spinal root
43
Shingles
Chickenpox is caused by the varicella zoster virus ). After recovery the virus remains in your DRG. * Sometimes in later life the virus can reactivate producing a painful or itchy rash that is isolated to a single dermatome
44
2 – point discrimination
is the ability to discern that two nearby objects touching the this ability reflects how finely innervated an area of skin is
45
Motor pools are made of motor units
Motor units make up motor pools: * a lower motor neurone (or alpha motor neurone) in the spinal cord innervates a muscle. * each motor neuron synapses with multiple fibres within the muscle. The motor neurone and all the muscle fibres it contacts define the motor unit. * cross section through the muscle shows the relatively diffuse distribution of muscle fibres (dark fibres) contacted by a single motor neuron
46
Spinal Enlargements
he arms and legs (particularly the hands and feet) have many highly innervated muscles and have a high density of sensory receptors. Because of this the portions od the spinal cord that provide the spinal nerves to the arms and legs are enlarged
47
information flow in a spinal segment
* dorsal horn - contains sensory neurones. these receive sensory information and send this up to the brain. * Ventral horn – contain neurones that send messages directly to the muscles. * intermediate zone –contain interneurones. these integrate information. e.g – inhibition.
48
coding in nervous systems is by action potentials
timulus intensity determines size of receptor potential & thus frequency of action potentials firing frequency codes for intensity (“rate code”) very non-linear usually codes for intensity of contrast between two levels.
49
rate coding in the motor system
* Motor neurons use a rate code to signal the amount of force to be exerted by a muscle. * An increase in the rate of action potentials fired by the motor neuron causes an increase in the amount of force that the motor unit generates.
50
rate coding in the motor system - recruitment & size principle
* For small forces small motor units are recruited first, as the required force increases, larger motor units are recruited. * Size principle states that, with increasing strength of input onto motor neurons, smaller motor neurons are recruited and fire action potentials before larger motor neurons are recruited.
51
early effects of training are neuronal in origin
* humans before and after dynamic training. - Note the increased rate of tension development after dynamic training * increased rate of of tension achieved after training is accompanied increase in rectified surface EMG activity in the early phase of contraction.
52
Subcortial control of movement
Title
53
spinal cord reflexes e.g. stretch reflex
Stretching a muscle is detected in the muscle and leads to increased activity in sensory neurones that in turn leads to an increase in the activity of motor neurons that innervate the same muscle, while inhibiting the motor neurons that innervate antagonists.
54
Reflexes
* rapid automatic control of movement. * little or no voluntary control. * some are very simple: * stretch reflex. * some are more complex: * swallowing, breathing. * these mainly happen in the spinal cord and low in the brain stem.
55
brainstem
the brainstem sits at the top of the spinal cord and is made of three parts: 1. medulla 2. pons 3. midbrain
56
2 important brainstem nuclei groups
The reticular formation is a set of interconnected nuclei that are located throughout the brainstem. The vestibular nuclei (VN) are the nuclei for the vestibular system and are located in the brainstem.
57
Vestibulospinal tract
The vestibular system is thesensory system that provides the sense of balance and spatial orientation for the purpose of coordinating movement with balance The vestibulospinal tract originates in the vestibular nuclei. They send most of their output to the spinal cord and to the muscles that move the eyes.
58
Reticulospinal Tract
* the reticular formation is a set of interconnected nuclei that are located throughout the brainstem. * It is a very old part of the brain. * The reticulospinal tract originates in reticular formation. * These tracts function in maintaining tone, balance, and posture.
59
cerebellum
* the cerebellum has a very conserved, highly folded structure in all animals * 10% volume of the brain. * More than neurones than the cortex. * 69Billion v 16Billion * input:output connections ratio. * 40:1
60
input/output (40:1)
Superior cerebellar peduncle * efferent (out) pathway to the red nucleus and the cortex (via the thalamus) & sup colliculus. Middle cerebellar peduncle: * most fibres originate in the pons * input from sensory, visual, vestibular and motor systems. * but its largest input is from the cortex. Inferior cerebellar peduncle * carries information to and from the the spinal cord (and the body) and vestibular nuclei
61
Rubrospinal Tract
The red nucleus is a roughly spherical collection of cell bodies in the midbrain. It is called the red nucleus because it is extremely vascular. In fresh tissue the red nucleus is distinctly pinker than the surrounding tissue. The red nucleus receives a very large input from the cerebellum and from the primary motor cortex.
62
basal ganglia
* movement regulation * skill learning * habit formation * reward systems * selection of appropriate behaviours * self-initiation of behaviours
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2 pathways- through the basal ganglia
* the DIRECT pathway that runs DIRECTLY through the basal ganglia * the INDIRECT pathway takes a longer loop through the basal ganglia.
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the loops start and finish in the cortex
DIRECT * short loop though the basal ganglia. * has excitatory effect on cortex. * Net effect is pro-movement. INDIRECT * long loop through the basal ganglia. * has inhibitory effect on cortex. * Net effect is anti-movement.
65
the BG and cerebellum do different/complementary things
basal ganglia * damage to the BG produces states where there is too much, or too little movement. cerebellum * damage to the cerebellum produces states where movements can still be made, but they are uncoordinated.
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cortical control of movement
title
67
Brain maps - homunculi
* Because of the close relationship with the body surface & muscles, both the primary sensory and motor cortex have detailed somatotopic maps of the body in them. * Areas of the body with many highly innervated muscles and densely packed sensory receptors have expanded representations in the brain.
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1. primary motor cortex
Neurones in the primary motor cortex have a simple relationship to movement. They fire around 5 to 100 ms before movement onset and can code for the basic parameters of movement, i.e.: * Force. * Direction. * Extent. * Speed
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2. other motor cortical regions exist (area 6)
As we have seen neurones in the primary motor cortex have a simple relationship with movement parameters. Neurones in the non-primary motor cortex have a more complex relationship to movement. They code for the more complex aspects of movement
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pre-motor cortex (orange area 6)
Neurones in the non-primary motor cortex have a more complex relationship to movement. They code for the more complex aspects of movement, for example: * planning movement. * spatial guidance of movement. * sensory guidance of movement.
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Supplementary motor cortex (SMA; purple area 6)
Neurones in the non-primary motor cortex code for more complex aspects of movement. They code for the more complex aspects of movement, for example: * coordinating temporal sequences of actions. * bimanual coordination. * initiation of internally generated as opposed to stimulus driven movement *NB – the SMA is well connected to the basal ganglia.
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SMA – bimanual coordination
* A monkey is trained to perform a complex bimanual task that requires the animal to push a peanut through a hole to collect a peanut. * After a lesion of the SMA the animal cannot perform this task and the function does not recover
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Areas closely associated with movement
These area are needed for complex movements and are highly interconnected with the motor areas
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primary sensory cortex (areas 1, 2 & 3)
* touch: vibration, heat, pain, pressure. * Proprioception: Afferent information, including joint position sense, kinesthesia, and sensation of resistance: * Joint position sense: The ability to recognize joint position in space. * Kinesthesia: The ability to appreciate and recognize joint movement or motion. * Sensation of resistance: The ability to appreciate and recognize force generated within a joint.
75
posterior parietal cortex. (areas 5&7)
* integration of sensory, visual information to execute complex movement in the environment. * representations for different motor effectors (e.g. arm vs. eye) * a command apparatus for operation of the limbs, hands and eyes within immediate extrapersonal space
76
corticospinal tract
The most important tract in the human for precise control of the limbs. * Origin: * primary motor cortex (30%) * Premotor, supplementary (30%) * Somatosensory, parietal, cingulate (40%) * About 1 million fibers in humans. * 90% cross at lower medulla * All are excitatory
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Increasing complexity as we go ‘up’ in the brain
he complexity of the movements the nervous system controls increases as you move toward (and through the brain): spinal cord – simple reflexes. medulla – complex reflexes. cerebellum – coordinated movement. basal ganglia – programmed movements. cortex – complex conscious movements.