Bradycaria/Hypotension

Question 1

which agent is more likely to cause hyperglycemia, CCB or BB?

Answer 1

CCB b/c it blocks L type Ca channels on pancreas which trigger release of insulin

Question 2

which is more likely to cause hypoglycemia, CCB or BB?

Answer 2

BB because β2-adrenoceptors normally stimulate hepatic glycogen breakdown (glycogenolysis) and pancreatic release of glucagon, which work together to increase plasma glucose. Therefore, blocking β2-adrenoceptors lowers plasma glucose.