BPH and Erectile Dysfunction

Question 1

Prostate is composed of what types of tissues (2 types)

Answer 1

1) Epithelial (glandular tissue) -> androgen stimulate is growth
2) Stromal (smooth muscle) tissue -> innervated by alpha 1 adrenergic receptors

Question 2

How does testosterone contribute to development of prostate?

Answer 2

Testosterone is converted to dihydrotestosterone by enzyme Type II 5 alpha reductase in the prostate
Dihydrotestosterone is needed for normal growth/enlargment of the prostate

Question 4

Explain the 2 main components in the pathophysiology of BPH

Answer 4

1) Static component: hormonal factors; testosterone converted to DHT leading to enlargement of prostate tissue -> urethral obstruction/signs and symptoms
2) Dynamic component: increase smooth muscle tissue and agonism of alpha-1 receptors -> narrowing of the urethra oulet -> urethral obstruction/signs and symptoms