BPH

Question 1

BPH Benign prostatic hyperplasia

Answer 1

Benign growth of prostate

Not cancer , does not lead to cancer

Question 2

Normal vs enlarged prostate

Answer 2

Small v big
Urethra unobstructed vs difficulty in urination
Free flow of urine vs incomplete bladder emptying

Question 3

Prostate

Answer 3

Surround urethra in men , if enlarged then squeezes the urethra

Involved in reproductive function

Question 4

5 alpha - reductase

Convert testosterone to DHT

Answer 4

DHT is more potent than testosterone

Question 5

Roles of androgen

Answer 5

DHT is principal androgen responsible for prostatic growth and BPH

Question 6

Oestrogen theory of bph

Answer 6

Oestrogen to testosterone ratio increase with age

Result in stromal (supporting tissue) overgrowth

Question 7

Drug options for BPH

Answer 7

5 alpha reductase inhibitor

Alpha adrenergic blocking drugs

Question 8

5 alpha reductase inhibitor drugs

Answer 8

Fina-steride *

Duta-steride

Question 9

Alpha adrenergic blocking drugs

Answer 9

Prazosin

Tamsulosin

Question 10

Finasteride

Answer 10

5 alpha reductase inhibitor

Short half life

• block conversion of testosterone to DHT
• reduce vol of prostate by at least 20%

Question 11

Tadalafil

Answer 11

Phospho-diesterase type 5 inhibitor

Relaxes smoothe muscle