BPE Flashcards
(118 cards)
What are the 4 examples of cell host?
- Bacteria
- Yeast
- Mammalian cells
- Insect
What is biopharmaceutical engineering?
The application of engineering principles to enhance the performance and production of biopharmaceutical products.
What is a signal peptide
A short peptide(16-30 amino acids long) present at the N-terminus
What is the N-terminus
The start of a protein or peptide
What is the first step in the process?
Objective
What does HEK cell stand for?
Human embryonic kidney cell.
What is the first step of the design process?
Objective
What is the second step of the design process?
Design Criteria
What is the third step of the design process
Measure
What is the fourth step of the design process?
Test
What is the fifth step of the design process?
Model
What is the sixth step of the design process
Design
What is the seventh step in the design process?
Validate
What is the eighth step in the design process?
Benefits
What are the 3 structures in the central dogma of molecular biology?
DNA, RNA, protein
What process converts DNA to RNA?
Transcription
What process converts RNA to DNA?
Reverse transcription
What process converts RNA to protein?
Translation
What are the products when cells are used as factories?
RNA, Proteins
What are the products when the cell is used as the product?
Cell therapies
What are the 3 parts of DNA?
Promoter - Coding sequence Ancillary DNA
What do promoters do?
Dictate the kinetics of gene expression
What are motifs?
Building blocks of DNA that bind proteins, interact with receptors and form secondary structures
How can DNA be redesigned?
Combining motifs in optimal order