Bornaviridae

Question 1

general characterisitcs

Answer 1

enveloped, single (-)ssRNA, persistent infection of neurons characteristic

Question 2

Disease

Answer 2

borna disease, neurologic usually fatal disease of horses

Question 3

hosts

Answer 3

horses and sheep in central europe

Question 4

in humans

Answer 4

behavioral and neuropsychiatric changes

Question 5

transmission

Answer 5

unclear, possible oro-nasal

Question 6

pathogenesis

Answer 6

virus pass intra-axonally to the olfactory bulbs of the brain from olfactory nerve endings
virus then disseminates throughout the CNS
replicates in neurons and glial cells

Question 7

inclusion bodies

Answer 7

distinctive eosinophilic intranuclear inclusions in neurons

“joest-degen” bodies are pathognomonic

Question 8

CS

Answer 8

early: dysfunctions in limbic system, horses- fever and behavioral changes
depression, altered eating behavior, head pressing, attacks of colic, nystagmus
later: dysfunction of motor systems causing paralysis

Question 9

advanced cases

Answer 9

hyperesthesia, ataxia, paresis, paralysis

Question 10

survivors

Answer 10

permanent sensory and or motor deficits