Bones/cells/function Flashcards
Name the 3 body planes
Coronal - separate front and back
Sagittal - cut straight down
Horizontal/transverse - cut top from bottom
Name some of the skeletons functions
Support, movement (joints), boundaries/protection (skull), hematopoiesis, triglyceride storage (yellow bone marrow), mineral homeostasis (mostly calcium and phosphate), attachment
Ventral VS dorsal?
Front VS back
Name the types of bone cells
Osteoblast, osteoclast, osteocyte, osteogenic
How many bones does the body have and what % of your body is the skeleton?
206 and 18%
What do the following support ribs/sternum, spine, cranium?
Lungs and heart
Spinal chord
Brain
What does haemaopoiesis mean?
Formation and development of blood cells from red bone marrow
Define osteoclasts:
Osteoclasts are lisosomal enzymes which dissolve/digest bone matrix.
Derived from up to 50 monocytes (WBCs)
What does resorption mean?
This is the breakdown of the bone matrix
What is the result of excess osteoclast activity?
Loss of bone density
Proximal VS distal
p=near the trunk
d=further from the trunk
Anterior (ventral) VS posterior (dorsal)
A= near the front P= near the back
Anterior is also known as
Ventral
Posterior also known as
Dorsal
Define Osteogenic cells
Bone stem cells that are the only bone cell to undergo division
Define osteoblasts and when they can be found where
Bone building cells and can be found at fracture sites, deep layers of periosteum, centers of ossification of immature bone
Define osteocytes
mature bone cells that do not divide. They monitor and maintain bone tissue
Define Osteoclasts
cells that break down bone, releasing calcium and phosphate. Giant cells with up to 50 nuclei from the fusion of many monocytes
What is resoprtion and why do we do it?
the break down of bone matrix in order to regerenate and replenish our skeleton
Osteoclast and osteoblast relationship
Osteoblasts and osteoclasts work together to remodel bone throughout life. Excess osteoclast activity leads to loss of bone density
Name the 2 types of one in the body
compact and spongy
What % of our skeleton is compact bone
80%
Define compact bone
compact bone is found beneath the periosteum of all ones and makes up the bulk of diaphysis of long bones
Define an osteon
a structural unit of compact bone. Osteons tend to be aligned in the same lines as stress which differs per individual i.e. crawling or walking. Your skeleton reflects the physical demands we put it through
What is diaphysis?
The shaft of a bone which is mainly compact bone
Why does our skeleton need constant remodeling?
to reflect the ohysical strain we put it through
Name the 4 parts of an osteon what what they do
Haversian : how we get blood in and out of compact bone, effective delivery of nutrients - center. Nerves and blood veddles
Lamellae : concentric rings of calcified extracellular matrix containing minerals and collagen. Rings of bony matrix. Give strength
Canaliculi : mini system of interconnected canals that provides a route for nutrients and waste to move through
Lucanae : small spaced called lacunae with osteocytes
Is the skeleton living?
Yes, it is formed of lots of living components and minerals which contains bone marrow in certain areas. This is why blood circulation needs to be strong.
Define spongy bone
20% of our skeletal mass is spongy bone. Its two main functions are to produce red blood cells from red bone marrow
what is found in macroscopic spaces between trabeculae?
Bone marrow/blood vessels
Define the bone matrix
the bone matrix contains minerals (mainly calcium phosphate then magnesium, sulphate and potassium) that combine together and are deposited and crystalized in the framework formed by collagen which form the ‘hardness’ of bone
What type of tissue is bone?
Connective tissue that contains osteoblasts/genic/cytes/clasts.
What is the most abundant mineral in bone?
Calcium phosphate
Define long bones
Bones that have a greater length than width
What is the epiphyses?
2 heads on a bone