Bone & Soft Tissue Pathology Buzzwords

Question 1

EXT1 and EXT2 mutation

Answer 1

Osteochondroma

Multiple osteochondroma syndrome

Question 2

IDH1 and IDH2 mutation

Answer 2

Chondroma/Enchondroma

Sporadic chondrosarcoma

Chromatosis-related chondrosarcoma

Question 3

“Central nidus surrounded by a rim of osteoblasts” on histology

Answer 3

Osteoid osteoma

Question 4

“Thick rind of cortical bone” on XR

Answer 4

Osteoid osteoma

Question 5

Rb or TP53 mutation

Answer 5

Osteosarcoma

Question 6

Codman’s triange on XR

Answer 6

Osteosarcoma

Question 7

“Lamellated and focally interrupted periosteal reactions” on XR

Answer 7

Ewing sarcoma

Question 8

Small blue round cell tumor

Answer 8

Ewing sarcoma

Question 9

“Onion skin” on XR

Answer 9

Ewing sarcoma

Question 10

Mutation in p53 inhibitor

Answer 10

Liposarcoma

Question 11

MYH9-USP6; t(17,22) fusion gene

Answer 11

Nodular fascitis

Question 12

+ for keratins and epithelial markers

Answer 12

Synovial sarcoma

Question 13

EXT1 and EXT2 =

IDH1 and IDH2 =

Rb + TP53 =

Answer 13

EXT1 and EXT2 = Osteochondroma

IDH1 and IDH2 = Enchondroma/Chondroma, Chondrosarcoma

Rb + TP53 = Osteosarcoma