Bone-modifying agents and hypercalcemia

Question 1

Epidemiology

Answer 1

20-30% of all cancer patients

Most common tumor types: Lung

Other causes: hyperparathyroidism, medications, renal failure

Question 2

HCM causes

Answer 2

1. Humoral (80%)
2. Local osteolytic hypercalcemia (20%)
3. 1,25 (OH) 2D-Secreting lymphomas
4. Ectopic hyperparathyroidism
5. Renal