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Bone Metastasis > Bone Mets > Flashcards

Bone Mets Flashcards

1
Q

Most common site of bone metastasis:

A

Axial Skeleton:
Spine
Lumbar spine
Is the most frequent site of bone metastasis

Pelvis
Ribs

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2
Q

Certain skeletal sites are associated with specific areas of bone metastases:

Scapular

A

Renal cancer

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3
Q

Certain skeletal sites are associated with specific areas of bone metastases:

Skull

A

Breast

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4
Q

Certain skeletal sites are associated with specific areas of bone metastases:

Distal appendicular skeleton

A

Lungs

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5
Q

Certain skeletal sites are associated with specific areas of bone metastases:

Toes

A

GUT

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6
Q

Normal bone

remodelling lasts around

A

100-120 days or 3-6 months

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7
Q

is the area between the
epiphysis and diaphysis.
“ an area of rapidly growingtrabecular bone.

A

Metaphysis

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8
Q

Most frequent site of bone metastasis
“ highest concentration in theaxial skeleton.
“ most often occurs by
hematogenous spread

A

Red bone marrow

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9
Q

What primary tumors are mostly osteolytic bone mets?

A

Breast

lungs

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10
Q

What primary tumors are mostly osteoblastic bone mets?

A

Thyroid

Prostate

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11
Q

PURELY osteolytic?

A

Myeloma

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12
Q

❖Plain radiographs is the most appropriate first imagingstudy

Disadvantage:
How many percent of the bone mineral
content must be lost before the lesion will be apparent on x-rays???

A

30-50%

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13
Q

best method for screening patients at risk for bone metastasis

A

technetium 99m bone scintigraphy

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14
Q

Useful in defining the extent of

cortical destruction and helping to assess the risk of a pathologic fracture

A

CT scan

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15
Q

Better in assessing the

involvement of trabecular bone(red marrow), especially in the vertebral bodies

A

MRI

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16
Q

c ommonl y us es t he 18-fluorodeoxyglucose (FDG) isotope

useful in detecting osteolytic bone metastases

A

PET scan

17
Q

Goals of surgical intervention:

A

Goals of surgical intervention:
to prevent or relieve pain
improve motor function
improve overall quality of life

18
Q

the sitemost likely to cause serious

morbidity.

A

Peritrochanteric femur

19
Q

Important predictors of risk of

fracture:

A 
Important predictors of risk of 
fracture: 
㾎 Size of the bone metastasis 
❑ lesions ≥2.5 cm in the cortex of 
the femur were significantly more 
likely to fracture 
㾎 Proportion of cortical destruction 
◇ Risk is significantly increased 
when the destruction is >50% of 
the cortex 
㾎 Location within the bone
20
Q

Prophylactic fixation is recommended in what MIrel’s scoring system?

A

> 9

21
Q

pain relief within 48 hours
percutaneous injection of
methylmethacrylate under CT orfluoroscopic guidance

A

Vertebroplasty

22
Q

in TAX327 phase III trial

Docetaxel can: _____________

A 
➢  an improvement inoverall survival 
➢  lower cancer-
induced bone pain 
➢ better objective 
tumor response
23
Q

Nitrogen-containing bisphosphonates inhibits what key enzyme in mevalonate pathway?

A

Farnesyl disphosphonate synthase

24
Q

Complications of supportive

therapy with bisphosphonates

A

osteoradionecrosis (particularly ofthe jaw)

renal insufficiency

25
Q

human
monoclonalantibody
specific for the RANK ligand

A

Denosumab

26
Q 
Effective in palliating painful bone metastases
partial pain relief seen in 
80% to 90% of patients 
complete painrelief in 50% 
of patients
A

RT

27
Q

Effectiveness of Radiation Treatment depends on the GOAL:

A 
Effectiveness of Treatment depends on the GOAL: 
I. Palliation of pain 
II. Prevention of 
pathologic fracture 
III. Avoidance of future 
treatments 
IV. Local control of the 
disease
28
Q

In Dutch trial, the response of RT on bone mets is within ____weeks

A

Responses occurred within the first 4to 6 weeks after treatment

29
Q

True or false?

Single-dose treatments of 8 Gy provide similar pain relief to longer treatment regimens (30 Gy in 10 fractions or 20 to 24 Gy in five to eight treatments).
The retreatment rates are higher after short course treatment by a factor of two to three.

A

TRUE

30
Q

Stereotactic Radiosurgery

The max tumor dose is:

A

12.5 to 25 Gy

31
Q

pure β-emitter

• with an energy of 1.4 MeV• half-life: 50.6 days

A

Strontium 89

32
Q

Common Primary Site for Metastases to the Bone:

A

Breast Cancer

Prostate cancer

Bone Metastasis (2 decks)

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