Bone Marrow Transplantation

Question 1

What organ is most susceptible to radiation? What is least susceptible?

Answer 1

Most: bone marrow
Least: CNS

Question 2

What is the outcome of stem cell transplant dependant on?

Answer 2

Points for prognosis
Age: <20 = 0 20-40 = 1, >40 = 2
Phase: Early = 0, int = 1, late = 2
Gender: female to male = 1
Time to BMT: <1 yr = 0, >1 yr = 1
Donor: sibling = 0, VUD = 1

Higher score = lower prognosis

Question 3

What are the signs of graft versus host disease?

Answer 3

• Erythematous rash
• Skin peeling
• GI failure
• Liver failure

Question 4

What is the treatment of graft versus host disease?

Answer 4

• Corticosteroids
• Cyclosporin A
• Antibodies

Question 5

What can be given to prevent graft versus host disease?

Answer 5

Methotrexate