Bone disease Flashcards
This porous bone disease is a chronic, progressive metabolic bone disease characterized by low bone mass and structural deterioration of bone tissue leading to increased bone fragility is defined as:
osteoporosis (silent thief)
The occurrence of bone fxs due to osteoporosis in females and males are:
1-2 in women, 1-8 in males
Why are women commonly affected w/osteoporosis:
low Ca intake, smaller frame, rapid bone reabsorption during menopause, pregnancy/breastfeeding, longevity
Risk factors for osteoporosis are:
Family hx, smoking/drinking, inactive lifestyle, low Ca/D diet, lone term use in corticosteroids
Normally, the rate of bone deposition and reabsorption (both defined as remodeling) are equal to each other. In osteoporosis:
bone reabsorption is greater than deposition
Bone mass is determined:
70% heredity, nutrition, exercise, hormone function
Where do osteoporosis occur:
spine (dowager’s hump), hips, and wrists
What are the clinical manifestations of osteoporosis:
Back pain, loss of height, spinal deformities (kyphosis)
When can a x-ray detect osteoporosis:
Goes undetected until 25-40 % of Ca is lost
What are the diagnostic studies for osteoporosis:
X-ray, bone mineral density (BMD) utilizing quantitative UZ on the knee, heel, shin, or using a dual-energy X-ray absorptiometry (DEXA) on the spine, hips, and forearm
Dual-energy x-ray absorptiometry (sound waves) are read as:
T-scores and will read bone density as either: normal, osteopenia, or osteoporosis
How do primary interventions effect osteoporosis:
Primary intervention retains bone health by: diet rich in Ca/D, weight-bearing exercises, no smokin, decreased EtOH intake, 20 min exposure to sun for D, bone density testing
Why should Ca supplements be spread out throughout the day and when should they be taken when taking abx:
Body won’t absorb more than 500 mg of Ca at one time, and supplements should be taken after 2-4 hrs after abx tx
What is the daily amount of Ca needed for women:
1000 mg for premenopausal, 1500 mg post menopause
How do secondary interventions effect osteoporosis and includes what type of medications:
Secondary intervention ATTAINS optimal bone health by: HRT-hormone replacement therapy; Calcitonin (decrease reabsorption), Bisphosphonates (reduce reabsorption), Selective estrogen Receptor (SERMs reduces reabsorption), teriparatide (for men w/increased risk of fx, increase action of osteoblasts), Denosumab (for women at increased risk of fx)
What are the types of bisphosphonates and how should they be taken:
Fosamax, Boniva, Reclasts (FBR) should be taken w/full glass of water, 30 min before food/meds, remain upright for 30 min
How do secondary intervention effect osteoporosis and includes what type of procedures or braces:
Secondary intervention ATTAINS optimal bone health by: thoracic-lumber-sacral-orthosis brace; Vetebroplasty (cement is injected for stabilization); kyphoplasty (bladder bag is inserted/inflated and then cement is injected)
How do tertiary interventions effect osteoporosis:
Tertiary interventions MAINTAIN optimal bone health by: incorporating primary/secondary interventions, reporting new pain sites, emphasizing safety to prevent fx: FALLS
A severe infection of the bone, bone marrow, and surrounding soft tissue that’s usually caused by S. aureus is defined as:
osteomyelitis
How can S. aureus cause osteomyelitis by indirect entry:
indirect entry: affects boys 12 or younger as a result from blunt trauma, adults w/vascular insufficiency (DM) or GU and respiratory infections
How can S. aureus cause osteomyelitis by direct entry:
open wound allowing entrance for microorganisms
Osteomyelitis infections occur by:
increased pressure (d/t # of organisms), ischemia/vascular compromise (caused by pressure), cortical devascularization (infection moving in deeper to bone), and sequestrum (bone death and medium bed for S.aureus)
Osteomyelitis that’s less than 1 mo and includes local and systemic manifestations is called:
Acute osteomyelitis
Systemic manifestations of osteomyelitis include:
Fever, night sweats, chills, restlessness, nausea