Bone, cartilage, and tendon revision Flashcards
What are the functions of bone?
Haematopoesis Movement Stucture Protection Ca2+ reservoir Energy store
List the types of bone shapes
Long Short Irregular Flat Sesamoid
What hormones involved in day to day bone homeostasis?
Vit-D3
PTH
Why is vitamin-D3 a hormone?
Made in one place and acts in another
Which populations are mainly at risk of developing vit-D3 deficiency?
Populations lacking sunlight, i.e. Finish
Populations with a poor diet
Where is PTH synthesised?
Parathyroid glands
What is the purpose of calcium homeostasis
To maintain a constant plasma Ca2+ level
What are the two compartments of a skeleton?
Axial
Appendicular
Em
a
What are the types of cell involved in bone metabolism?
Osteoclasts
Osteoblasts
Osteocytes
Blood vessels and nerves
What do tendons connect?
Muscle to bone
What do ligaments connect?
Bone to bone
What connects muscle to muscle?
Aponeuroses
How is muscular force initially transmitted to bone?
Via the musculotendinous junction
What are the two sites of muscular/tendinous attachment to bone?
Origin (stationary)
Insertion (moves)
What are the compartments of muscles and tendons called?
Fascicles
Give example models of skeletal unloading
Atronauts
Bed rest
Give three methods of measuring bone mineral density.
DEXA scan
qCT - quantitative computerised tomography
Ultrasound
What is the GOLD standard for measuring outcomes of a trail of osteoporosis?
Fractures
What is the name given to osteocyte processes occupying canals?
Canaliculi
How do osteocytes respond to loading/mechanical stress?
Bone metabolism
What cells are osteocytes derived from?
Osteoblasts
Where do chondrocytes live?
In a hole called a lacuna
What are the major components of articular cartilage?
Water
Type II collagen
Proteoglycans
What is the main reason for cartilage healing poorly?
Avascular
Double diffusion system
Loss of stem cell population in older people
- due to wearing away
Name the main proteoglycan?
Aggrecan
What are the interventions for small to medium sized defects in articular cartilage?
Autologous Chondrocyte Implantation Debridement Regeneration enhancement, i.e. microfracture Osteochondral grafting Cell based therapies