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Physiology > Body Fluid compartment:Osmotic and Oncotic pressure > Flashcards

Body Fluid compartment:Osmotic and Oncotic pressure Flashcards

1
Q

What is Osmosis

A

Osmosis is the movement of fluid through a semipermeable membrane towards higher osmolar concentration of solute
In osmosis water goes where the solute is more concentrated.

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2
Q

What is the Osmolarity of a solution

A

Osmolarity is the concentration of osmotically active particles. It is a measure of the concentration of particles in a solution, calculated as mM/L x g, where g is the number of particles associated with a molecule of solute in solution

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3
Q

What gives the ability for Osmosis to happen

A

Osmosis is driven by differences in concentration of dissolved particles between two solutions

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4
Q

What is the osmolarity value of the body

A

300mosm/L

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5
Q

What is an isotonic solution

A

This is a solution that is the same concentration as the body

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6
Q

What are some examples of isotonic solutions

A

150mM Nacl and 300mM glucose

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7
Q

What is iso-osmotic

A

Same osmolar concentration

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8
Q

What ions make up the intracellular and extracellular fluids

A

Sodium and potassium

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9
Q

What is Osmotic pressure

A

The external pressure that would be required to prevent solvent flow across a membrane

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10
Q

Higher solute concentrations have higher osmotic pressure and draw water.true or false?

A

True

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11
Q

Less permeable solute exert more effective osmotic pressure.true or false

A

True

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12
Q

What characteristic of Albumin makes it generate great osmotic pressure

A

Albumin is impermeable to cell membranes and contributes to the osmotic pressure of capillary fluid as “colloid osmotic pressure”, or “oncotic pressure”, favoring fluid movement into the circulation at capillaries as opposed to out

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13
Q

What kind of pressure does albumin generate?

A

Colloid osmotic pressure or oncotic pressure.

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14
Q

Does Albumin favor fluid movement into the circulation at capillaries or out of circulation?

A

Into circulation

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15
Q

What are some examples of solutes that are permeable into the cell membrane

A

Urea is a rapidly permeating solute across the cell membrane; glycerol is a slowly permeating solute.

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16
Q

What are some examples of solutes that are less permeable

A

sodium, Sucrose

17
Q

What is Tonicity?

A

Tonicity is the effective osmolarity of a solution, a measure of a solution’s ability to create an osmotic pressure gradient relative to another solution

18
Q

what is Relative osmolarity

A

refers to the concentration of osmotically active particles in a solution relative to a reference solution

19
Q

What is Relative tonicity

A

considers only the particles that are impermeant to the biological membrane separating two solutions.
eg: urea and NaCl

20
Q

What are the major body fluid compartments

A
  1. Intracellular Fluid

2. Extracellular fluid:i)Interstitial Fluid.ii)Plasma

21
Q

What is the % of water in and ideal body size?

A

total body water (TBW) is ~60% of body weight, or 42 L in 70 kg person

22
Q

How is the total body water volume divided by volume between the ICF,ECF,ISF and Plasma

A 
Intracellular fluid (ICF) = 2/3 TBW (28L)
Extracellular fluid(ECF) = 1/3 TBW (14 L)
Interstitial fluid (ISF) = ~3/4 ECF (11 L)
Plasma vol (PV) = ~1/4 ECF (3L)
23
Q

In increasing order, who has the highest amount of TBW per gender

A

old women,old men,young women,young men,infant

24
Q

in the ECF,% of Cations in the plasma is > % in the ISF

True or False?

A

True(Nakcm) sodium,potassium,calcium,magnesium)

25
Q

What physiological response happens when plasma osmolarity rises greater than 2%

A

elicit a thirst response, as well as a systemic response to retain fluid (i.e., decrease urine, sweat and saliva production), to keep cells “shrinking” and the intracellular electrolyte concentrations from rising

26
Q

What indicator is used for plasma body compartment

A

Evans Blue

27
Q

What indicator is used for ECF body compartment

A

Inulin

28
Q

What indicator is Used for TBW

A

Tritiated water

29
Q

Calc Volume of ICF

A

Intracellular Fluid = TBW-ECF

30
Q

Calc Volume of ISF

A

Interstitial Fluid = ECF- Plasma

31
Q

Calculate Volume in a compartment

A

Volume (L) = Amount of indicator injected (mg) /

Final concentration of indicator (mg/L)

32
Q

cation that contributes most to intracellular fluid is?

A

Potassium

33
Q

Which of the following is the most abundant in plasma

Na,K,Bicarb,cl,protein

A

Sodium

34
Q

cation most in extracellular fluid

A

sodium

35
Q

ANion contribute most in intracellular fluid

A

phosphate

36
Q

Anion contribute most in Extracellular fluid

A

Chloride

37
Q

an increase in tissue hydrostatic pressure will cause fluid shifts from were to were?

A

from interstitial fluid space into the vascular (plasma) compartment

Physiology (11 decks)

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