Boc Flashcards

1
Q

A patient with myeloproliferative disorder has the following values:

Hgb:

Hct:

WBC:

platelets:

serum Nat:

serum K+:

13 g/dL (130 mmol/L)

38%

30 x 103/uL (30 x 109/L)

1000 x 10 /μL (1000 x 109/L)

140 mEq/L (140 mmol/L)

7 mEq/L (7 mmol/L)

The serum Kt should be confirmed by:

arepeat testing of the original serum

testing freshly drawn serum

testing heparinized plasma

atomic absorption spectrometry

A

C

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2
Q

48

What battery of tests is most useful in evaluating an anion gap of 22 mEq/L (22 mmol/L)?

Catt, Mgt, PO4 and pH

BUN, creatinine, salicylate and methanol

c AST, ALT, LD and amylase

d glucose, CK, myoglobin and cryoglobulin

A

B

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3
Q

The degree to which the kidney concentrates the glomerular filtrate can be determined by:

a urine creatine

b serum creatinine

creatinine clearance

durine to serum osmolality ratio

A

D

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4
Q

29

Factors that contribute to a PCO2 electrode requiring 60-120 seconds to reach equilibrium include the:

diffusion characteristics of the membrane

actual blood PO

ctype of calibrating standard (ie, liquid or humidified gas)

d potential of the polarizing mercury cell

A

A

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5
Q

25

What is the best method to diagnose lactase deficiency?

H breath test

b plasma aldolase level

c LDH level

d D-xylose test

A

A

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6
Q

14

Which one of the following values obtained during a glucose tolerance test are diagnostic of diabetes mellitus?

2-hour specimen = 150 mg/dL (8.3 mmol/L)

Fasting plasma glucose = 126 mg/dL (6.9 mmol/L)

fasting plasma glucose = 110 mg/dL (6.1 mmol/L)

2-hour specimen = 180 mg/dL (9.9 mmol/L)

A

B

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7
Q

12

In the fasting state, the arterial and capillary blood glucose concentration varies from the venous glucose concentration by approximately how many mg/dL (mmol/L)?

1 mg/dL (0.05 mmol/L) higher

5 mg/dL (0.27 mmol/L) higher

10 mg/dL (0.55 mmol/L) lower

d 15 mg/dL (0.82 mmol/L) lower

A

B

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8
Q

9

Serum levels that define hypoglycemia in pre-term or low birth weight infants are:

a the same as adults

b lower than adults

c the same as a normal full-term infant

d higher than a normal full-term infant

A

B

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9
Q

98

MLS

ONLY

The identification of Bence Jones protein is best accomplished by:

a sulfosalicylic acid test

urine reagent strips

immunofixation

aelectrophoresis

A

C

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10
Q

70 A low concentration of serum phosphorus is commonly found in:

patients who are receiving carbohydrate hyperalimentation

chronic renal disease

hypoparathyroidism

d patients with pituitary tumors

A

A

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11
Q

61 A physician requested that electrolytes on a multiple myeloma patient specimen be run by direct ISE and not indirect ISE because:

a excess protein binds Na in indirect ISE

Na is falsely increased by indirect ISE

Na is falsely decreased by indirect ISE

excess protein reacts with diluent in indirect ISE

A

C

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12
Q

60

Sodium determination by indirect ion selective electrode is falsely decreased by:

elevated chloride levels

belevated lipid levels

decreased protein levels

d decreased albumin levels

A

B

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13
Q

59

Which of the following is true about direct ion selective electrodes for electrolytes?

whole blood specimens are acceptable

b elevated lipids cause falsely decreased results

celevated proteins cause falsely decreased results

d elevated platelets cause falsely increased results

A

A

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14
Q

125 Serum concentrations of vitamin B12 are elvated in:

MLS

ONLY

a pernicious anemia in relapse

bpatients on chronic hemodialysis

chronic granulocytic leukemia

Hodgkin disease

A

C

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15
Q

135 In bilirubin determinations, the purpose of adding a concentrated caffeine solution or methyl MLS ONLY

alcohol is to:

allow indirect bilirubin to react with color reagent

dissolve conjugated bilirubin

c precipitate protein

d prevent any change in pH

A

A

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16
Q

148 A condition in which erythrocyte protoporphyrin is increased is: MLS

ONLY

acute intermittent porphyria

biron deficiency anemia

C porphyria cutanea tarda

d acute porphyric attack

A

B

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17
Q

117 Which of the following substances is the biologically active precursor of a fat soluble vitamin?

MLS

ONLY

biotin

B retinol

folic acid

d ascorbic acid

A

B

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18
Q

115 Technical problems encountered during the collection of an amniotic fluid specimen caused doubt y as to whether the specimen was amniotic in origin. Which 1 of the following procedures would best establish that the fluid is amniotic in origin?

a measurement of absorbance at 450 nm

b creatinine measurement

lecithin/sphingomyelin ratio

d human amniotic placental lactogen (HPL)

A

B

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19
Q

110 A patient with glomerulonephritis is most likely to present with the following serum results: MIS

ONLY

a creatinine decreased

b calcium increased

phosphorous decreased

dBUN increased

A

D

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20
Q

102

MLS ONLY

An elevated serum iron with normal iron binding capacity is most likely associated with:

a iron deficiency anemia

renal damage

pernicious anemia

d septicemia

A

C

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21
Q

What specimen preparation is commonly used to perform the alkaline phosphatase isoenzyme determination?

a_serum is divided into 2 aliquots, one is frozen and the other is refrigerated

serum is divided into 2 aliquots, one is heated at 56°C and the other is unheated

no preparation is necessary since the assay uses EDTA plasma

d protein-free filtrate is prepared first

A

B

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22
Q

186 Regan isoenzyme has the same properties as alkaline phosphatase that originates in the:

a skeleton

b kidney

intestine

d placenta

A

D

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23
Q

187 The most heat labile fraction of alkaline phosphatase is obtained from:

a liver

bebone

Lintestine

a placenta

A

B

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24
Q

187 The most heat labile fraction of alkaline phosphatase is obtained from:

a liver

bebone

Lintestine

a placenta

A

B

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25
192 Which of the following enzyme substrates for prostatic acid phosphatase is best for the MLS ONLY continuous monitoring method? a phenyl-phosphate b thymolphthalein monophosphate alpha-naphthyl-phosphate beta-glycerophosphate
C
26
195 The most consistent analytical error involved in the routine determination of HDL-cholesterol is MLS ONLY caused by: a incomplete precipitation of LDL-cholesterol coprecipitation of HDL- and LDL-cholesterol inaccurate protein estimation of HDL-cholesterol a small concentration of apoB-containing lipoproteins after precipitation
D
27
198 In familial hypercholesterolemia, the hallmark finding is an elevation of: low-density lipoproteins b chylomicrons c high-density lipoproteins dapolipoprotein A
A
28
199 Premature atherosclerosis can occur when which of the following becomes elevated? MLS ONLY a chylomicrons b prostaglandins low-density lipoproteins high-density lipoproteins
C
29
177 A 10-year-old child was admitted to pediatrics with an initial diagnosis of skeletal muscle disease. The best confirmatory tests would be: a creatine kinase and isocitrate dehydrogenase b gamma-glutamyl transferase and alkaline phosphatase aldolase and creatine kinase lactate dehydrogenase and malate dehydrogenase
C
30
178 In the immunoinhibition phase of the CKMB procedure: aM subunit is inactivated b B subunit is inactivated c MB is inactivated d BB is inactivated
A
31
252 Which of the following is useful in the detection and management of carcinoma of the prostate? total prostate-specific antigen b prostatic acid phosphatase human chorionic gonadotropin d alpha-fetoprotein
A
32
242 A patient has signs and symptoms suggestive of acromegaly. The diagnosis would be confirmed if y the patient had which of the following? a an elevated serum phosphate concentration a decreased serum growth hormone releasing factor concentration ho decrease in serum growth hormone concentration 90 minutes after oral glucose administration d an increased serum somatostatin concentration
C
33
243 Estrogen and progesterone receptor assays are useful in identifying patients who are likely to benefit from endocrine therapy to treat which of the following? ovarian cancer breast cancer endometriosis d amenorrhea
B
34
Night blindness is associated with deficiency of which of the following vitamins?
A
35
Beriberi is associated with deficiency of vitamin:
Thiamine
36
Scurvy is associated with deficiency of which of the following vitamins?
C
37
Rickets is associated with deficiency of which of the following vitamins?
D
38
Pellagra is associated with deficiency of which of the following vitamins?
Niacin
39
229 The biologically most active, naturally occurring androgen is: MLS ONLY androstenedione b cortisol epiandrosterone d testosterone
D
40
5 During a normal pregnancy, quantitative human chorionic gonadotropin (HCG) levels peak how many weeks after the last menstrual period? 2-4 b 8-10 c 14-16 d 18-20
B
41
222 During pregnancy, the form of estrogen measured in urine is mostly: estradiol estriol c estrone d pregnanediol
B
42
218 The screening test for congenital hypothyroidism is based upon: arSH level in the newborn b thyroid-binding globulin level in the newborn Total thyroxine (T4) level in the newborn iodine level in the newborn
C
43
208 Chylomicrons are present in which of the following dyslipidemias? familial hypercholesterolemia hypertriglyceridemia deficiency in lipoprotein lipase activity d familial hypoalphalipoproteinemia
C
44
204 A 9-month-old boy from Israel has gradually lost the ability to sit up, and develops seizures. He has an increased amount of a phospholipid called GM2-ganglioside in his neurons, and he lacks the enzyme hexosaminidase A in his leukocytes. These findings suggest: Neimann-Pick disease Tay-Sachs disease phenylketonuria d Hurler syndrome
B
45
285 Unless blood gas measurements are made immediately after sampling, in vitro glycolysis of the blood causes a: arise in pH and PCO bfall in pH and a rise in PO rise in pH and a fall in PO dfall in pH and a rise in PCO
D
46
279 The different water content of erythrocytes and plasma makes true glucose concentrations in ONLY whole blood a function of the: hematocrit b leukocyte count erythrocyte count d erythrocyte indices
A
47
An active metabolite of amitriptyline is: MLS ONL nortriptyline protriptyline butriptyline d norbutriptyline
A
48
Phenobarbital is a metabolite of: primidone b phenytoin c amobarbital d secobarbital
A
49
Testing for the diagnosis of lead poisoning should include: a erythrocyte protoporphyrin (EPP) urine delta-aminolevulinic acid whole blood lead zinc protoporphyrin (ZPP)
C
50
267 A drug that relaxes the smooth muscles of the bronchial passages is: a acetaminophen b lithium Phenytoin theophylline
D
51
A cardiac glycoside that is used in the treatment of congenital heart failure and arrhythmias by increasing the force and velocity of myocardial contraction is: digoxin acetaminophen c lithium d phenytoin
B
52
A salicylate level is performed to detect toxicity caused by ingestion of excess: acetaminophen aspirin ibuprofen d pseudoephedrine
B
53
266 An antiepileptic (or anticonvulsant) used to control seizure disorders is: a digoxin b acetaminophen lithium phenytoin
D
54
262 The metabolite 11-nor-tetrahydrocannabinol-9-COOH can be detected by immunoassay 3-5 days after a single use of: a methamphetamine b cocaine benzodiazepine d marijuana
D
55
259 Which of the following factors is not relevant to therapeutic drug monitoring (TDM) of the y aminoglycosides, antibiotics and vancomycin? a intestinal absorption nehrotoxicity c ototoxicity d renal function
A
56
354 Which of the following applies to cryoscopic osmometry? atemperature at equilibrium is a function of the number of particles in solution 6 temperature plateau for a solution is horizontal c freezing point of a sample is absolute d initial freezing of a sample produces an immediate solid state
A
57
355 Assay of transketolase activity in blood is used to detect deficiency of: MLS ONLY thiamine folic acid ascorbic acid d riboflavin
A
58
355 Assay of transketolase activity in blood is used to detect deficiency of: MLS ONLY thiamine folic acid ascorbic acid d riboflavin
A
59
350 The substance that is measured to estimate the serum concentration of triglycerides by most methods is: phospholipids glycerol fatty acids pre-beta lipoprotein
B
60
349 Which of the following is a glycolytic enzyme that catalyzes the cleavage of fructose-1, 6-diphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate? a aldolase b phosphofructokinase pyruvate kinase dglucose-6-phosphate dehydrogenase
A
61
347 The International Federation for Clinical Chemistry (IFCC) recommends the use of methods such as the Bessey-Lowry-Brock method for determining alkaline phosphatase activity. The substrate used in this type of method is: a monophosphate b phenylphosphate disodium phenylphosphate d para-nitrophenylphosphate
D
62
339 In the Malloy and Evelyn method for the determination of bilirubin, the reagent that is reacted with bilirubin to form a purple azobilirubin is: dilute sulfuric acid diazonium sulfate sulfobromophthalein ddiazotized sulfanilic acid
D
63
336 Which of the following calcium procedures utilizes lanthanum chloride to eliminate interfering substances? a o-cresolphthalein complexone b precipitation with chloranilic acid chelation with EDTA d atomic absorption spectrophotometry
D
64
333 Which of the following would be an example of a glucose-specific colorimetric method? MIS alkaline ferricyanide bglucose oxidase hexokinase d o-toluidine
Bb
65
331 Magnesium carbonate is added in an iron binding capacity determination in order to: a allow color to develop b precipitate protein bind with hemoglobin iron dremove excess unbound iron
D
66
328 Which blood gas electrode is composed of silver/silver chloride reference electrode and glass? a PO2 pH PCO2 d HCO3
C
67
327 Valinomycin enhances the selectivity of the electrode used to quantitate: a sodium b chloride potassium d calcium
C
68
354 Which of the following applies to cryoscopic osmometry? atemperature at equilibrium is a function of the number of particles in solution 6 temperature plateau for a solution is horizontal c freezing point of a sample is absolute d initial freezing of a sample produces an immediate solid state
A
69
354 Which of the following applies to cryoscopic osmometry? atemperature at equilibrium is a function of the number of particles in solution 6 temperature plateau for a solution is horizontal c freezing point of a sample is absolute d initial freezing of a sample produces an immediate solid state
A