Board Flashcards
Why should the dose of a medication be decreased when a patient stops smoking?
Smoking induces CYP1A2, lowering clozapine serum levels; upon cessation, levels rise.
How can liver disease impact drug levels in the body?
Liver disease affects enzyme activity, leading to potentially toxic drug levels.
What effect does kidney disease have on drug concentrations?
Kidney disease or drugs reducing renal clearance can increase serum drug levels.
What makes older adults more sensitive to psychotropics?
Factors include decreased metabolism, protein binding, muscle mass, and increased body fat concentration.
Why are inducers and inhibitors of enzymes important to know in drug therapy?
They impact drug levels which can lead to subtherapeutic or toxic levels.
What are some examples of drugs that can reduce renal clearance of lithium?
Examples include NSAIDs, thiazides, and ACE inhibitors like HCTZ.
Where is norepinephrine produced in the brain?
Norepinephrine is produced in the locus coeruleus and medullary reticular formation.
What is the role of GABA in the brain and how does it relate to anxiety?
GABA is an inhibitory NT; decreased levels can increase anxiety.
What are some risk factors associated with Autism Spectrum Disorder?
Risk factors include being male, genetic loading, and intellectual disability.
Which part of the brain is the largest and divided into lobes?
The cerebrum is the largest part of the brain, divided into lobes.
Define tolerance in relation to drugs.
Tolerance is the process of becoming less responsive to a particular drug over time.
What are the three levels of prevention in mental health?
Primary, secondary, and tertiary prevention.
What is the primary aim of primary prevention?
Decreasing the incidence of mental disorders.
Give an example of secondary prevention in mental health.
Screening programs or telephone hotlines.
What is the focus of tertiary prevention in mental health?
Decreasing disability and severity.
What are the DSM-5 criteria for ADHD in adults?
≥ 5 symptoms per category, noticeable in ≥ 2 settings, impact on functioning.
What are the common neurotransmitter dysfunctions in ADHD?
Dopamine, norepinephrine, and serotonin dysfunction.
What are the signs of stimulant abuse in ADHD?
Insomnia, tremors, elevated blood pressure, mood swings, etc.
Name a non-stimulant medication used for ADHD.
Strattera (atomoxetine).
What are some nonpharmacological management strategies for ADHD?
Behavioral therapy, psychoeducation, family therapy, etc.
Describe the primary symptoms of Borderline Personality Disorder.
Impulsivity, recurrent suicidal behavior, intense relationships, identity disturbances.
What treatment approach is recommended for Borderline Personality Disorder?
Dialectical Behavioral Therapy (DBT).
List some characteristics of Antisocial Personality Disorder.
Reckless, deceitful, lack of remorse, impulsivity, disregard for others.
What are the core symptoms of Rett Syndrome?
Loss of purposeful hand skills, stereotypic hand movements.
What is unique about the physical exam findings in Rett Syndrome?
Loss of purposeful hand skills and stereotypic hand movements.
What are tics in Tourette’s Disorder?
Involuntary, repetitive movements and vocalizations.
What are the primary neurotransmitters involved in Tourette’s Disorder?
Dopamine, Norepinephrine, Serotonin.
What is the pharmacological management for Tourette’s Disorder?
Atypical antipsychotics, Haldol, Pimozide, Aripiprazole.
What nonpharmacological management strategies can be used for Tourette’s Disorder?
Behavioral therapy, CBT, Deep Brain Stimulation.
What are the differential diagnoses for Tourette’s Disorder?
Chronic Motor or Vocal Tic Disorder, Stereotypic Movement Disorder.
What are the positive symptoms of schizophrenia?
Hallucinations, Delusions, Referential thinking, Disorganized behavior, Hostility.
What are the negative symptoms of schizophrenia?
Affective flattening, Alogia, Abolition, Apathy, Abstract thinking problems, Anhedonia, Attention deficits.
What are the associated neurobiological defects in schizophrenia?
Enlarged ventricles, Smaller frontal and temporal lobes, Cortical atrophy, Decreased cerebral blood flow.
What alterations in chemical neuronal signal transmission occur in schizophrenia?
Excess dopamine, Excess glutamate, Decreased GABA, Decreased serotonin.
What preventative care measures should be taken for individuals with schizophrenia?
Monitor routine labs, Serum glucose and lipid panels, Weight/BMI, Eye exams, Liver and kidney function.
What are Erikson’s stages of development and their characteristics?
Trust vs. Mistrust, Autonomy vs. Shame and Doubt, Initiative vs. Guilt.
What nonpharmacological management strategies can be used for schizophrenia?
Individual/group therapy, Assertive Community Treatment.
What is the virtue associated with the stage of industry vs. inferiority?
Competency
What is the virtue associated with the stage of identity vs. role confusion?
Fidelity
What is the virtue associated with the stage of intimacy vs. isolation?
Love
What is the virtue associated with the stage of generativity vs. stagnation?
Care
What is the virtue associated with the stage of integrity vs. despair?
Wisdom
What is the unfavorable outcome of the industry vs. inferiority stage?
Inferiority in understanding and organizing
During which stage does a personal sense of identity develop according to Erikson’s theory?
Identity vs. role confusion
What is the age range for the stage of intimacy vs. isolation?
20-35 years
What stage focuses on giving time and talents to others in middle adulthood?
Generativity vs. Stagnation
What stage involves fulfillment and comfort with life in late adulthood?
Integrity vs. Despair
At what age range does the formal operational stage begin according to Piaget’s stages of cognitive development?
12 years to adulthood
What concept describes a child’s ability to know that objects continue to exist even when not seen or heard?
Object permanence
At what age range does the concrete operational stage occur according to Piaget?
7-11 years
Which of Freud’s stages involves focusing on the genitals?
Phallic stage
What is the age range for the oral stage in Freud’s psychosexual stages?
0-18 months
What muscle relaxant is recommended for treating neuroleptic malignant syndrome (NMS)?
Dantrolene
What are the symptoms of serotonin syndrome?
Hyperreflexia, myoclonic jerks, agitation, rapid heart rate, elevated blood pressure, headache, sweating, shivering, confusion, fever, seizures.
What is the onset time for serotonin syndrome?
Within hours
How should serotonin syndrome be treated?
Discontinue offending agent, use Cyproheptadine
What are the symptoms of serotonin discontinuation syndrome?
Flu-like symptoms, insomnia, nausea, imbalance, sensory problems, hyperarousal, fatigue, lethargy, myalgia, decreased concentration, vomiting, ataxia, impaired memory, agitation.
What are the effects of an agonist on receptors?
Activates a biological response by opening the ion channel
What is the difference between an inverse agonist and a partial agonist?
Inverse agonist causes opposite effect, partial agonist has limited actions.
What type of drug binds to receptors but does not activate a biological response?
Antagonist
Define delusion and paranoia.
Delusion: False belief despite evidence. Paranoia: Belief that others are against you.
What is assessed in a mental status exam?
Appearance, behavior, speech, mood, affect, thought process, thought content.
What components are included in the Mini Mental Status Exam (MMSE)?
Concentration, orientation, speech, registration, recall, fund of knowledge.
Name some instruments for assessing cognitive impairment.
Montreal Cognitive Assessment (MoCA), Mini Cog, St Louis University Mental Status Exam (SLUM)
What age groups have a higher suicide risk based on gender?
Age 45 or older for males, age 55 or older for females.
List some risk factors for suicide.
Previous suicide attempts, older age, divorced/single/separated, white, living alone.
What are the key features of delirium?
Acute onset, altered level of consciousness, inattention, changes in cognition and concentration.
What is the preferred treatment for agitated delirious patients?
Haloperidol (Haldol) per APA guidelines.
What are the pharmacological management options for delirium?
Antipsychotic agents, atypical agents, anxiolytics for insomnia.
What is the one-year mortality rate for clients with delirium?
Up to 40%.
What are the types of dementia based on cortical and subcortical characteristics?
Cortical (affects cerebral cortex) and Subcortical (dysfunction below cortex).
What functional deficits are associated with cortical dementia?
Apraxia, Agnosia, Aphasia.
What is the hallmark of Lewy body disease?
Recurrent visual hallucinations.
What are the early signs of dementia due to HIV disease?
Cognitive decline, motor abnormalities, behavioral abnormalities.
What is the second most common type of dementia?
Vascular dementia.
What is the cardinal feature of Huntington’s disease?
Motor abnormalities (choreoathetoid movements).
What are the key characteristics of Disruptive Mood Dysregulation Disorder (DMDD)?
Chronic dysregulated mood, frequent temper outbursts, severe irritability, anger, no identifiable stressor.
What is a characteristic of Intermittent Explosive Disorder (IED)?
Involves repeated sudden episodes of impulsive, aggressive, violent behavior or angry verbal outbursts.
What neurotransmitters are dysregulated in Major Depressive Disorder (MDD)?
Dopamine, norepinephrine, serotonin (DNS).
What cognitive and memory symptoms of MDD in older adults are often confused with dementia?
Pseudodementia.
What does SIGECAPS stand for in the context of MDD?
Sleep disturbance, interested reduced, guilt/self-blame, energy loss/fatigue, concentration problems, appetite changes, psychomotor changes, suicidality.
What are the differences between Dementia and Pseudodementia?
Onset, progression, insight, behavior, memory, disability emphasis, affect, psychiatric history, suicide risk.
What is the recommended duration for continuing antidepressants in MDD treatment?
Minimum of 6-12 months; 2+ prior episodes consider continuing indefinitely.
What are the first-line and second-line pharmacological treatments for MDD?
First-line: SSRIs; Second-line: TCAs.
What are the non-pharmacological management options for MDD?
ECT, TMS, CBT.
What are the contraindications for Electroconvulsive Therapy (ECT)?
Cardiac disease, compromised pulmonary status, history of brain injury or tumor, anesthesia medical complications.
What are the potential adverse effects of Electroconvulsive Therapy (ECT)?
Possible cardiovascular effects; systemic effects like headaches, muscle aches, drowsiness; cognitive effects like memory disturbances, confusion.
How should suicidal ideation be managed clinically?
Always assume seriousness; assess and intervene promptly.