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Pre-reg BNF questions > BNF questions > Flashcards

BNF questions Flashcards

1
Q

What is the oral loading regimen for amiodarone?

A

200mg TDS for 7 days, 200mg BD for 7 days, 200mg OD maintenance

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2
Q

Outline amiodarone monitoring requirements

A

LFTs, thyroid function every 6months, K+ before treatment, chest Xray before treatment

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3
Q

How does amiodarone and warfarin interact?

A

Amiodarone inhibits warfarin metabolism. Leads to enhanced anticoagulant effect

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4
Q

How do amiodarone and beta blockers interact?

A

Increased risk of bradycardia, AV block and myocardiac depression

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5
Q

How does amiodarone and digoxin interact?

A

Plasma concentration of digoxin is increased by amiodarone. Need to half dose.

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6
Q

What is the desired serum concentration of digoxin?

A

1-2mcg/L

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7
Q

Changes in what electrolyte increases the risk of digoxin toxicity?

A

Potassium - hypokalemia increases risk of toxicity

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8
Q

What is the desired serum concentration of phenytoin?

A

10-20mg/L

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9
Q

Carbamazepine = enzyme inducer or inhibitor?

A

Inducer

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10
Q

Phenytoin = enzyme inducer or inhibitor?

A

Inducer

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11
Q

Ciprofloxacin = enzyme inducer or inhibitor?

A

inhibitor

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12
Q

Rifampicin = enzyme inducer or inhibitor?

A

Inducer

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13
Q

Clarithromycin = enzyme inducer or inhibitor?

A

Inhibitor

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14
Q

Smoking = enzyme inducer or inhibitor?

A

Inducer

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15
Q

Fluconazole = enzyme inducer or inhibitor?

A

Inhibitor

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16
Q

Pseudoephedrine and MAOI leads to what?

A

Hypertensive crisis

17
Q

What is the treatment for diabetic ketoacidosis?

A

Variable rate insulin infusion
Sodium chloride
Potassium chloride

18
Q

How does heparin induced hyperkalemia occur?

A

Inhibition of aldosterone secretion by heparin can result in hyperkalemia

19
Q

Atypical antipsychotics are associated with a higher risk of what in elderly patients? Give two examples of atypical antipsychotics

A

Increased risk of cerebrovascular events i.e. stroke.

Halloperidol, risperidone, olanzapine

20
Q

Extrapyrimidal side effects and withdrawal syndrome are reported to the MHRA more commonly with X than with other SSRIs

A

Paroxetine

21
Q

Sumatripan should be avoidedin patients with what co-morbidity?

A

Should not be used in IHD or angina

22
Q

What action should you take if a patient develops a rash with lamotrigine?

A

Consider withdrawal if rash or signs of hypersensitivity syndrome develop.

23
Q

Why are non-ergot derived dopmaine receptor agonists preferred?

A

Ergot-derived dopamine receptor agonists bromocriptine,f carergoline have been associated with pulmondary retroperitoneal and pericardial fibrotic reactions.

24
Q

Rare flucloxacillin side effect involving the liver…

A

Very rarely cholestatic jaundice and hepatitis may occur up to several weeks after treatment has been stopped.

Pre-reg BNF questions (1 decks)

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