BME331

Question 1

Wound-healing process

Answer 1

1. Injury
2. Coagulation (scab)
3. Swelling
4. Repair and remodeling

Question 2

When was modern FDA formed

Answer 2

1938

Question 3

Comparative device law

Answer 3

1962 - Kefauver-Harris Drug Amendments

Question 4

Issues arising from metallic biomaterials

Answer 4

Stress shielding - Wolff’s law
Biofilm formation
Corrosion (low vs high toxicity)

Question 5

Solutions for problems in using metals as biomaterials

Answer 5

Biolfilm
- use anti-adhesive coating to prevent attatchement
- coating with anti-bacterial peptides/proteins
- release bactericidal agents from surface (Zn, Hg)
- incorporate nanotography to disrupt adhesion

Corrosion
- surface modification with Cr2O3

Stress shielding

Question 6

Properties of ceramics

Answer 6

Hard, brittle
High compressive stress
Can withstand high temperatures

Question 7

Structure of ceramics

Answer 7

Crystalline

Question 8

Where are ceramics used

Answer 8

Orthopedic implants, dental applications

Question 9

Natural polymers are made up of

Answer 9

Tissue + mineral component

Question 10

Polymer property

Answer 10

Low chemical reactivity
Not dense
Cannot conduct heat or electricity well

Question 11

Biological polymer examples

Answer 11

Carbohydrates - glycogen
Proteins - collagen
Nucleic acids - RNA

Question 12

Polymer advantages

Answer 12

Ease of processing
Low friction
Infection resistance

Question 13

Polymer applications

Answer 13

• Weight bearing and articulating surfaces for knew/hip
• Sutures
• Tubing

Question 14

Passivation

Answer 14

Solution for metal - Corrosion

Question 15

Suture materials

Answer 15

1. Non degradable polymers
   - UHMWPE fiber
   - PP
   - PET
2. Resorbable sutures
   - PLA, PGA, PLGA
   - contain ester groups, making them water-degradable