Blood transfusions Flashcards
What are indicators for blood transfusions?
a. Anemia
b. Thrombocytopenia
c. Bone marrow suppression
d. Disseminated intravascular coagulation
e. Trauma
f. Hemophilia–> Deficient in a specific body clotting protein (A or B). These are normally synthesized in liver or epithelial cells
What makes up whole blood?
- RBC’s
- platelets
- plasma
- granulocytes
What is plasma made up of?
- fresh frozen plasma
2. fractionated products
What are RBC’s
the oxygen carrying component of the blood
When is a blood transfusion indicated for platelets?
severe thrombocytopenia –> 20,000
Less than 50,000 platelet count posses a risk for what?
risk for bleeding
How long can platelets be stored in a blood blank?
5 days
What makes up 55% of your total blood volume?
plasma
What is in the plasma?
proteins (albumin especially), clotting factors, hormones, glucose, electrolytes
When is plasma indicated?
chronic liver disease, DIC, too much of their Coumadin or warfarin (INR is high).
How long can fresh frozen plasma be stored? How long does it take to freeze it?
36 months; 8 hours
How long is the 1/2 life for clotting factors in FFP?
4-5 hours
What do you want to check with FFP?
- clotting factors
2. INR
What is cryoprecipitate?
product that is made when FFP is thawed and further centrifuged down.
Why might someone receive cryoprecipitate?
fibrinogen deficiency associated with trauma situations
What are fractionated plasma products?
manufactured products that are made without the use of a donor. It is contained in the plasma that can be broken down to be given to patients.
What are fractionated products broken down into?
- factors
- Albumin
- immune globulin
What are factors?
recombinant factors that are made in a lab
What do factors reduce
the amount of blood borne pathogens that can be given to a patient
When is albumin given?
given to patients with a protein deficiency.
What is albumin indicated for?
when a patient needs volume expansion or to raise oncotic pressure. Given to patients who have LIVER DISEASE
What is immune globulin?
different antibodies that are given to patient to help boost their immune system
Can granulocytes be transfused?
No; but they are still a component of the blood
What does the O allele code for?
codes for a protein that is not functional and does not produce surface molecules. Universal donor.