Blood Transfusions Flashcards
Indications for RBCs transfusion
- Symptomatic in a normovolemic patient regardless of H/H
- Acute blood loss w/ evidence of inadequate O2 delivery
- Hemoglobin <7 in a hemodynamically stable hospitalized patient
How much volume in a Unit of RBCs
~300ml (200ml of red cells)
1 Unit of RBCs raises H/H by how much?
1g/dL and 3% unless active bleeding
What can happen to K, after transfusion of 1 unit
causes +10 mEq since K leaks out of red cells in stored blood; monitor in CKD
Citrate
- present in stored blood
- can result in metabolic alkalosis (citrate~bicarb).
- Ionized calcium may be decreased from calcium+citrate complexing
Indications for Platelets
- Platelet count of <10 in non-bleeding patient w/ marrow suppression
- <20,000 for most bedside procedures
- consider higher threshold (<30,000) for patients who are febrile/septic
- <50,000 if actively bleeding ; and before surgery
- <100,000 if CNS bleed, or before ocular or CNS procedure
One apheresis unit should raise platelet count by ______?
30K within 1 hour
Platelet refractoriness = ?
defined as increment of <10K on two or more occasions
FFP contains ….?
all coagulation factors
FFP indications : ???
- Active bleeding in the setting of an INR >1.5 (includes in the setting of liver disease, DIC, warfarin overdose, vitamin K deficiency)
- INR>2 in non-bleeding patient scheduled for surgery or invasive procedure
- Maybe TTP (plasma exchange is preferred)
INR of FFP…?
as high as 1.5, and generally doesn’t correct the INR to below 1.6
Cryoprecipitate contains : _________?
VIII, XIII, vW F, fibrinogen and fibronectin
FFP that is thawed at 4 degrees C
Indications for transfusion of cryoprecipitate: ???
Fibrinogen < 100 mg/dl in the setting of consumptive coagulopathy (DIC) or severe bleed
Other Uses:
- Treat von Willebrand’s disease when DDAVP unsuitable.
- Alternative to factor concentrate in Hemophilia A
Leukoreduced blood components :_________?
– Removal of leukocytes through filtration to <106. Done to prevent complications of PRBC transfusion related to WBCs (transfusion reaction, CMV infection). Most hospitals automatically do this for PRBCs now.
Indications for leukoreduced product:????
- Chronically transfused patients (HLA sensitization)
- Potential or previous transplant recipients
- Patients w/ previous febrile non-hemolytic transfusion rxn
- CMV seronegative at-risk patients (b/c CMV lives in white cells)