blood products + reversal agents Flashcards
who gets packed red cells
used for transfusion in chronic anaemia + cases where infusion of large volumes of fluid may result in cardiovascular compromise
who gets platelet rich plasma
patients who are thrombocytopenic + are bleeding or require surgery
who gets platelet concentrate
patients with thrombocytopenia
first line therapy for hypovolaemia
fresh frozen plasma
whats in fresh frozen plasma
clotting factors
albumin
immunoglobulin
which factor is cryoprecipitate key for replacing
factor VIII
- rich source of factor VIII + fibrinogen
- allows large concentration of factor VIII to be administrated in small volume
which blood product can be ABO INcompatible in adults
platelets
management when immediate or urgent surgery required in patients taking warfarin
- stop warfarin
- Vit K
- 1st line = human prothrombin complex (give with vit K)
fresh frozen plasma (if prothrombin complex not available)
- need blood group
how long does vit K take to work
IV = 4-6hrs
oral = 24hrs (to be clinically effective)
Dabigatran MoA
direct thrombin inhibitor
Dabigatran reversal agent
idarucizumab
rivaroxaban, apixaban, endoxaban, MoA
direct factor Xa inhibitor
andexanet alfa is a reversal agent for which drugs
rivaroxaban
apixaban
–> direct factor Xa inhibitors
example use cases of cryoprecipitate
DIC
liver failure
hypofibrinogenaemia secondary to massive transfusion
emergency situs for haemophiliacs (when specific factors not available)
von willebrand disease
irradiated blood product
depleted of T-lymphocytes + used to avoid transfusion-assoc graft vs host disease
(caused by engraftment of viable donor T lymphocytes)
red cell transfusion threshold in patient with vs without acute coronary syndrome (ACS)
without ACS - 70
(target after transfusion - 70-90)
with ACS - 80
(target after transfusion - 80-100)
these should not be used in on going major haemorrhage or those requiring regular transfusions for chronic anaemia
what temp should RBCs be stored
4 degrees prior to infusion
in a non urgent situ, how quickly are RBCs usually transfused over
90-120 mins
