blood preservation

Question 1

3 areas of RBC biology are crucial for normal erythrocyte survival and function

Answer 1

1. normal chemical composition and structure of rbc membrane
   2.hemoglobin structure and function
   3.rbc metabolism

Question 2

it represents a semipermiable lipid bilayer supported by meshlike protein cytoskeleton structure

Answer 2

rbc membrane

Question 3

main lipid components of rbc membrane, are arranged in a bilayer structure comprising the framework in which globular proteins transverse and move

Answer 3

phospholipid

Question 4

proteins that extend from the outer surface and span the entire membrane to the inner cytoplasmic side of the rbc

Answer 4

integral membrane proteins

Question 5

second class membrane protein,located and limited to the cytoplasmic surface of the membrane forming RBC cytoskeleton

Answer 5

peripheral proteins

Question 6

biochemical composition of rbc membrane

Answer 6

52% protein
40% lipid
8% carbohydrate

Question 7

the rbc memebrane is relatively impermiable to cations such as___ and ___

Answer 7

sodium and potassium

Question 8

ancillary pathways

Answer 8

1. hexose monophosphate pathway/pentose phosphate pathway
   2.Luebering-rapoport shunt
   3.methemoglobin reductase sunt

Question 9

product of pentose phosphate pathway

Answer 9

NADH and ribose-5-phosphate

Question 10

removal of abnormal rbc morphology; has hemolytic reaction

Answer 10

culling

Question 11

other names for methemoglobin reductase pathway

Answer 11

cytochrome b5 reductase

Question 12

to maintain the iron in Hgb in ferrous state (Fe2)

Answer 12

methemoglobin reductase pathway

Question 13

provides 2,3 DPG;2,3 BPG

Answer 13

Luebering rapoport shunt

Question 14

BPG and DPG means

Answer 14

biphosphoglycerate and diphosphoglycerate

Question 15

hemoglobin’s primary function

Answer 15

gas transport:oxygen delivery to tissues and CO2

Question 16

one of the most important controls of Hgb affinity for oxygen

Answer 16

RBC organic phosphate 2,3 DPG

Question 17

normal shape for oxygen dissociation curve

Answer 17

sigmoid’s shape

Question 18

decrease if oxygen binding capacity of hemoglobin with the increase of the concentration of carbon dioxide or decrease in pH

Answer 18

bohr effecr

Question 19

decrease of carbon dioxide binding capacity of hemoglobin with the rise in concentration of oxygen

Answer 19

haldane effect

Question 20

measure of in vivo rbc survival following transfusion

Answer 20

rbc viability

Question 21

approved anticoagulant preservative solutions for whole blood and rbc storage at __-

Answer 21

1-6C

Question 22

binds calcium

Answer 22

citrate

Question 23

provides energy for red cells

Answer 23

dextrose/glucose

Question 24

lowers pH preventing caramilization

Answer 24

citric acid

Question 25

increase ATP, maintains adequate 2,3 DPG levels

Answer 25

phosphate buffer