Blood lipids Flashcards
What are the major groups of lipids?
Fatty acids
- Long Carbon chain with COOL
- Metabolic fuels stored as triglycerides
Cholesterol
- Diet and liver
- Essential component of cell membranes
Triglycerides
- Glycerol backbone with 3 fatty acid residues
- Energy source
Lipoproteins
- Lipid and apoprotein
- Solubility
How do you transport insoluble lipids into the hydrophilic environment of the blood?
Marry them to a protein! (Apoprotein)
Multifunctional protein:
- Maintain structural integrity of the lipoproteins
- Regulate enzymes acting on lipoproteins
- Receptor recognition
Defects cause dyslipidaemia
Lipoproteins: Lipid and an apoprotein
What are the three roles:
- Interorgan fuel
- Distribution
- Maintain cholesterol pool
What determines the lipoprotein class?
The apoprotein determines the lipoprotein class
What is the function of chylomicrons?
Main carrier of dietary triglycerides
What is the function of VLDL?
Main carrier of endogenously produced triglycerides
What is the function of LDL?
Main carrier of cholesterol
What is the function of HDL?
Protective
Draw a table of composition, major apolipoproteins, mean diameter and density of:
- Chylomicrons
- VLDL
- LDL
- HDL
Exogenous pathway- chylomicrons
Exogenous pathway VLDL
Endogenous pathway- LDL
- LDL receptor binds to apoB100
- Its expression is regulated by intracellular cholesterol concentrations
- Mediates cellular uptake of intact LDL
- Mutations can result in severe inherited forms of hypercholesterolemia
HDL
- HDL is involved in the reverse transport of cholesterol
- Mops up free cholesterol
- Binds to Scavenger receptor type B1 (SRB1) on hepatocytes
- Cholesterol excretion via bile
What is dyslipidaemia?
Abnormally elevated levels of lipids and/or lipoproteins within the blood
• WHO (Fredrickson) classification for primary hyperlipidaemia
Draw a tree of primary hypercholesterolaemia
Draw a tree of secondary hypercholesterolaemia
Familial hypercholesterolaemia