BLOOD GAS Flashcards
Normal blood pH
7.35-7.45
Enzyme need to convert Carbonic Acid to Bicarbonate ion?
Carbonic Anhydrase
Dissociated of H2CO3 __________ in HCO3 causing it to _____ into the plasma
- Increased
- Diffuse
Ratio of Bicarbonate ion to Carbonic Acid
20:1
If CO2 doesn’t excreted, what will happen?
There’s an increase og H+ ion concentration which leads to acidic pH or acidosis.
rapid or fast removal of CO2 by the lungs
Decreas the H+ ion concentration which leads to respiratory alkalosis.
Function of Kidneys
To excrete acid
How many acid must be excreted daily by the kidney
50-100 mmol/L
buffering
effects of hemoglobin causing venous
blood to be 0.03 unit lower in pH
chloride-isohydric shift
each Celsius above 37°:
↑ pH by 0.015
optimum pH for arterial blood
7.40
TO MAINTAIN pH
- neutralize acid as they are generated
- elimination of the acid permanently
Factors that causes Bicarbonate to increase
IV infusion of lactate, acetate and HCO3-
Factors that causes Bicarbonate to decrease
Diuretics, reduced reabsorption, chronic nephritis
Urinary excretion of HCO3
26 – 30 mmol/L
Normal excretion rate of bicarbonate
10 mEq/day
Ceased excretion of HCO3-
↓ 25 mmol/L
Major extracellular blood buffer
Carbonic Acid & bicarbonate
Weak acid/ base blood buffer
Plasma proteins
02 carry blood buffer
Hemoglobin
1 gram hemoglobin carries
1.39 ml of oxygen
1 mole of hemoglobin binds
1 mole of oxygen
1st line of defense against pH
Chemical buffer system:
1. Bicarbonate
2. Phosphate
3. Proteins
2nd line of defense against pH
Physiologic Buffer System