Blood Disorders (Exam 3) Flashcards
Where do platelets derive from?
Bone-marrow megakaryocytes
What is the life-span of a platelet?
8-12 days
How many platelets are formed daily?
120-150 million
What are the 3 phases of platelet alteration? How can you remember the order that they go in?
Adhesion-> Activation->Aggregation
Add Acid Gradually
During the 2nd phase, activation, what are the 2 types of storage granules released?
Alpha granules
Dense bodies
What are the 4 complexes required in each stage of the clotting cascade?
Substrate
Enzyme
Cofactor
Calcium
What is a good mnemonic to remember the order of the clotting factors?
Foolish People Try Climbing Long Slopes After Christmas. Some People Have Fallen.
What factor doesn’t exist anymore and is therefor not mentioned in the clotting cascade?
Factor VI (6)
List the factors in order of factor number
Fibrinogen, Prothrombin, Tissue Factor, Calcium, Labile, Stabile, Anti-hemolphilia A, Christmas, Stewart-Prower, PTA, Hageman, Fibrin stabalizing factor.
What factors are in the intrinsic pathway?
12, 11, 9, 8
What factors are in the Extrinsic pathway?
3, 7
What factors are in the final common pathway?
10, 2, 1, 13
Which pathway is more of an amplification system?
Intrinsic
How does factor XII (12) get activated?
contact with a negatively charged surface
Intrinsic propagation
5, 7, 8, 11 are used to amplify thrombin generation
Common pathway propagation
Xa turns II into IIa that turns I into Ia with help of XIII
What is the key step in regulating hemostasis?
Thrombin generation
What converts II into IIa?
Prothrombinase comples
There are 4 main coagulation counter-mechanisms:
Fibrinolysis
Tissue Factor Pathway inhibitor
Protein C System
SERPINS
Explain each on next slides
