Blood Disorders Flashcards
1
Q
Hemophilia A
A
Factor VIII (8) Deficiency Intrinsic Pathway Increased APTT Increased clotting time Normal bleeding time Normal platelets X-Linked Recessive
2
Q
Hemophilia B
A
Factor IX (9) Deficiency Intrinsic Pathway Increased APTT Increased clotting time Normal bleeding time Normal platelets X-Linked Recessive
3
Q
von Willebrand Disease
A
Defective platelet plug formation & vWF Factor VIII (8) Deficiency Increased bleeding time Increased APTT Normal PT / INR Normal platelets Increased mucosal bleeding, epistasis Ristocetin Assay
4
Q
Thrombocytopenia
A
Increased bleeding time Decreased platelet count Normal clotting time Normal APTT Normal PT / INR
5
Q
Bernard-Soulier Syndrome
A
GPIb deficiency Defective platelet plug formation Increased bleeding time Normal clotting time Normal APTT Normal PT / INR Normal Platelets
6
Q
Glanzmann Thrombasthenia
A
Defective GPIIb/IIIa Defective platelet plug formation Increased bleeding time Normal clotting time Normal APTT Normal PT / INR Normal platelet count
7
Q
Vitamin K deficiency
A
Decreased Factor II, VII, IX, X, Protein C & S Defect in Extrinsic pathway Normal bleeding time Increased clotting time Normal APTT Increased PT / INR time
