Blood component therapy Flashcards
what are packed red blood cells and what do they contain
PRBC are RBCs with little plasma (hct 75%); some platelets & WBCs
how long can PRBC be stored
• PRBCs stored at 4 degrees safely up to 42 days
what would PRBC be indicated for
to Inc RBC mass
Symptomatic anemia
The platelets aren’t functional nor are the WBCs.
The WBCs might cause reaction
how are platelets stored & kept well-functioning
• Platelets at room temp last up to 5 days
o To prevent clumping they are gently agitated
platelets can be from single donor or random. Why would single be used
Repeated tx with random donors can lead to alloimmunization
If pt needs repeat Tx then they should be given single donor platelets
indications for platelets
Bleeding d/t dec platelets or to prevent bleed when pt has low platelets
cryoprecipitate is made of
Cryoprecipitate: fibrinogen, AHF (VIII:C), von Willebrand factor, fibrinonectin
indication for cryoprecipitate
Von Willebrand disease
Hypofibrinogenemia
Hemophilia A
what conc does albumin come in and what is it for
Albumin (5% or 25%)
Hypoproteinemia, burns, volume expansion by 5% to inc blood vol (in hypovolemic shock), give 25% albumin to dec hct
why give immunoglobulins
which globulins are you giving specifically
Hypogammaglobulinemia (in CLL or recurrent infects); idiopathic thrombocytopenia; primary immunodeficiency
gamma globulins. IgG
what is whole blood & why is it indicated
Whole blood that is composed of cells & plasma (hct 40%)
Volume replacement & 02 carrying capacity
Usually only for significant bleed >25% blood vol lost
which blood components can be heated to get rid of viral components
• Immune globulin is conc IgG & can be heated to 60* for 10hrs as can albumin to get rid of viruses
not sure if stuff about blood transfusion is important
what health hx is it nec to know for someone giving blood transfusion
• Donor is carefully interviewed for viral hep, STIs, stays in places with higher risks of other diseases, have they received transfusions, skin infect, hypersensitivity (as it can be passed on), pregnancy (shouldn’t give blood as they need it), immunization recently, CA, whole blood donation in past 56 days, aspirin affects platelets
what diseases can be passed on by blood transfusion
o Hep B & C (screening detects this)
o AIDS (blood screened for antibodies to HIV)
o Cytomegalovirus
o Graft vs host disease (only in severely immunocompromised recipients. Can irradiate blood for this)
o Creutzfeldt-Jakob disease (rare, fatal neurodegenerative disease that causes irreversible damage. It is a prion. Like mad cow disease)
physical requirements for blood donor
o Exceed 50kg for a standard donation of 450ml
o Older than 17
o Oral temp not exceed 37.5
o Pulse rate between 50-100
o Systolic 90-180 and diastolic 50-100
o Hg at least 1.94 for woman and 2.1 for men
what are the different kinds of blood donation
directed donation standard donation autologous donation intraoperative blood salvage hemodilution
what is directed donation
blood to friend or family but not necessarily safer bc might not be willing to identify any history of risk factors ie) HIV
how much blood is taken during a standard donation
-how long does it take & what to do or tell them to do
phlebotomy consists of venipuncture and blood withdrawl. Withdrawal of 450 ml of blood usually takes up to 15 min Hold arm up after and apply firm pressure for 2-3 minutes. Donor remains recumbent until they feel able to sit up. Receives foods and fluid and stay for 15 minutes.
autologous donation
how many units can be taken & when are they not taken
patients own blood for future potential surgeries (orthopedic sx). Ideally collected 4-6 weeks early. Iron supplements given to prevent iron depletion. Typically 1 unit of blood/week. Phlebotomies are not performed within 72 hours of surgery
what is the advantage of autologous donation
should everyone do this to prevent risk?
o Primary adv is prevention of viral infections from other blood also safe for ppl who have a history of transfusion reacitons, prevents alloimmunization and avoidance of complications to patients with alloAbs
o Needless autologous donation is disciouraged bc expensive, takes time, and uses resources inappropriately
o Might be inadequate-need more from random donors anyway
what is intraoperative blood salvage
• - provides replacement for patients who cannot donate blood before surgeru and for those underging vascular, orthopedic, or thoracic surgery
o During a surgical procedure, blood lose into a sterile cavity (hip joint0 is suctioned into a cell-saver macine. PRBCs or whole blood are washed with saline, filtered, and returned to patient as IV infusion
med surg ssecond section
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what is the consideration with using older blood
• Caution with old blood cells cause continual destruction of RBC causes release of K out of cells into plasma. Lab test of K ordered before administering unit of blood
what are the 3 blood system types
ABO, RH, & human leukocyte antigen
how does ABO system work
what happens with incompatible RBCs
- ABO uses presence or absence of specific antigens on surface of RBC
- When type A antigen is present, blood group is type A
- Antibodies that react against the A and B antigens are present in the plasma of people whose RBC do not carry the antigen. These antibodies (agglutinins) react against the foreign antigens (agglutongens).
- Incompatible RBC agglutinate (clup together) and result in life-threatening hemolytic transfusion reaction
who is the universal recipient
type AB have neither antibody and can receive all blood types
what surface antigens does a person with O blood have and therefore what blood can they receive
have both A & B antibodies so they can only receive O blood
what is the RH system and which Rh antigen is most common and likely to cause reaction
if pt has this antigen are they positive or negative
- Nearly 50 types of Rh antigen may be present on surface of RBC, D cell is widely prevalent and most likely to illict an IR.
- Presence or absence of D that determines Rh type
- With D makes you positive
- No antibodies to D antigen (unlike ABO)
how is a pt sensitized and what makes them have a reaction
how long would this take
- Person with Rh neg blood must first be exposed to Rh pos blood before Rh antibodies are found. If exposed to enough blood (200ml) then can cause severe reaction
- These Abs take up to 2 weeks to form
must all blood that is given be matched to the pts Rh
• Rh pos blood may be used for a person with Rh neg without adverse effect if that person has not been previously exposed to Rh pos eg in trauma
implications of Rh negative mom who is having a baby
when would she get tx & what would this entail
- Rh neg mom previously exposed to Rh antigen can transfer Rh antibodies across placenta resulting in fetal hemolysis (breakdown of RBC with resultant anemia and jaundice) often fatal to infant
- To prevent current or future fetal hemolysis, Rh (D) immunoglobulin (RhoGam) given IM to mom to suppress or destroy the fetal Rh pos blood cells that passed on
what is HLA and what are they found on
what are complications of HLA
- Highly immunogenic antigens can cause transfusion complications
- HLA Ab are on surface of leukocytes
- May be found on lymphocytes, granulocytes, monocytes, and platelets
complications:
o Febrile nonhemolytic reaction (FNH)
o Immune mediated platelet refractoriness
o Tranfusion-related acute lung injury (TRALI)
o Transfusion-associated graft-versus-host disease (tA- GVHD)
what is the most common reaction to blood therapy
why is it caused
and who does it gen occur in
Febrile Nonhemolytic Reaction
- Caused by antibodies to donor leukocutes or platelets that remain in the unit of blood or blood component.
- Often occurs in pt who had previous transfusions (exposure to multiple antigens from blood products) and in rh neg woman who have borne Rh positive children
onset of febrile nonhemolytic rxn
and how to prevent it
30min after initiation to 6hrs affter completion of transfusion
to prevent use leukocyte reduced products in pts who have experienced this complication before
mnfts of febrile nonhemolytic rxn
fever >1 degree above baseline, flushing, chills, headache, muscle pain; occurs most freq in immunosuppressed pts
intervention if febrile nonhemolytic rxn
stop transfusion
antipyretic
monitor temp q4h
what is acute hemolytic rxn and how quickly would it occur
• Antibodies already present in the recipients plasma rapidly combine with antigens on donors erythrocytes and the erythrocytes are destroyed in circulation. There is either an ABO or Rh incompatability
ocurs within 15mins of transfusion initiation. ABO incompability is faster
mnfts of acute hemolytic rxn
- Symp: fever up to 41*, chills, severe low back pain and chest pain, nausea, chest tightness, dyspnea, and anxiety, tachycardia, sensation of heat and pain along vein receiving blood, chills,bronchospasm , HoTN, DIC, vascular collapse, possible death
- As erythrocytes are destroyed, th Hg is released from the cells and excreted by the kidneys, therefore hg appears in the urine (hemoglobinuria) hypotension, bronchospasm, and vascular collapse may result
- Dimished renal perfusion results in ACF and DIC
how much blood is nec for acute hemolytic rxn
• Can occur in as little as 10ml of PRBCs
interventions for acute hemolytic rxn
stop transfusion and remove blood tubin and product.
notfy
VS q15
correct arterial P and coagulopathy according to orders
catheter
I/O hourly
assess for shock
dialysis may be nec
blood and urine samplessent to lab along with the blood that caused rxn
delayed hemolytic transfusion rxn onset
how does it work
• Occurs within 2- 14 days when level of antibody has been increased to the extent that a reaction can occur
there is immune response against non-ABO donor Ags. gen the result of destr of transfused RBCs by alloAbs not detected during cross match
• The hemolysis of the erythrocutes is extravascular via the RES and occurs gradually
how to prevent delayed hemolytic transfusion rxn
mnfts
careful cross match
can be missed as it occurs so late
unexplained fever,
unexplained dec in Hgb/Hct
inc biliruin levels
jundice
nurs intervention for delayed hemolytic trnsfusion rxn
monitor lab values for anemia (next time could be full acute hemolytic rxn)
allergic rxn (mild to moderate)
onset in
mnfts
• Thought to be from sensitivity to plasma protein within blood component being transfused
onset during transfusion to 1hr after transfusion
• Symp: itching, urticarial, and flushing, local erythema
prevention & interventions
- If severe- epinephrine, corticosteroids, and vasopressor support
- can Give pt antihistamines before as preventative meas
stop transfusion notifu give antihistamines VS q15 transfusion can be restarted if fever, dyspnea, wheezing not present
what happens in severe allergic rxn
is it faster than mild to mod allergic rxn
caused by recipient allergy to donor antigen usually IgA
agglutination of RBCs obstr caps & blocks blood flow causing issues w all organ systems
onset withing 5-15mins of initiation of transfusion
mnfts of severe allergic rxn
coughing nausea V dyspnes resp distress wheezing HoTN l/o consciousness possible cardiac arrest
interventions for severe allergi rxn
how to prevent
life threatening! stop transfusion keep IV acess Notify and notify blood bank too antihistamines, corticosteroids, epinephrine and antipyretics as ordered VS until stable CPR?
to prevent: transfusion of saline washed or leukocyte depleted RBCs
graft vs host disease:
what is it
when does it occur
what is it: donor lymphocytes destroyed by recipients IS. If pt is immunocompromized the donor lymphocytes are seen as foreign but the pts IS cant destroy them and in turn the pts lymphocytes are destroyed
when does it occur: days to weeks
mnfts of graft vs host disease
interventions
skin rash
fever
jaundice d/t liver dysfx
bone marrow suppression
give methotrexate and corticosteroids as ordered
what is often the max rate for transfusion ml/kg/hr
2-4ml/kg/hr
iron overload when might this occur and whats is happening
might occur w multiple transfusion or hronic transfusion therapy
the iron from the donated blood binds to the protein and isnt eliminated
mnfts of iron overload
nursing intervention
cardiac dysfx SOB arrythmias heart failure inc serum transferring inc liver enzymes jaundice
monitor for above issues