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BLOOD COMPONENT > BLOOD COMPONENT > Flashcards

BLOOD COMPONENT Flashcards

1
Q

HARD SPIN/HEAVY SPIN

5000g- 5mins

A

PRBC PC

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2
Q

HARD SPIN

5000g - 7mins

A

CRYOPPT, LP-RBC, CELL FREE PLASMA

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3
Q

LIGHT SPIN OR SOFT SPIN

2000G-3MINS

A

PRP

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4
Q

Replace the loss of both RBC mass and plasma volume in actively bleeding patients. loss of 25% of their blood volume

A

Whole blood

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5
Q

No viable platelets or WBC

A

Whole blood

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6
Q

Decreased labile: Factors V/ VIII

A

Whole blood

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7
Q

Days of exchange transfusion?

A

6 days

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8
Q

Treatment of symptomatic anemia where oxygen capacity is needed

A

Packed red blood cells

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9
Q

Tolerate an increased blood volume

A

Packed red blood cells

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10
Q

Adavantages of RBC over whole blod

A
  1. Equal O2 in half vlume of WB
  2. Reductions of isoagglutinins
  3. Reduction in the kevels of acid, citrate, and potassium w/ cardiac, renal, liver
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11
Q

For neonates

A

RBC ALIQUOTS

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12
Q

Treatment of anemia caused by:

A
  1. FETOMATERNAL HEMORRHAGE
  2. OBSTETRIC ACCIDENTS
  3. INTERNAL HEMORRHAGE
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13
Q

Average unit of RBC contains ____

A

2x10^9 leukocytes

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14
Q

a reduced leukocyte content to less than _____

A

5x10^8

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15
Q

prevents repeated non-hemolytic febrile trans reaction

A

Leukocyte Reduced Red Blood Cells

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16
Q

less than 5x10^6 prevents what?

A

HLA sensitization

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17
Q

how to reduce immunosuppression of recipient by?

A

donor WBC

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18
Q

prevents alloimmunization to ____

A

HLA antigens, CMV transmission and recurrent FNH reactions

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19
Q

TRUE OR FALSE: does not prevent graft versus disease

A

TRUE

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20
Q

What generation and pore size?

screen filter- removes fibrin clots

A

First 170-260um

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21
Q

What generation and pore size?

micropore screen filter-remove aggregates such as plt., nuclei, degenerated WBC, cell fragments, and nuclei

A

Second 20-40um

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22
Q

What generation and pore size?

Adhesion filter- removes 99.9% of WBC leaving less than 5x10^8 WBC

A

Third NA

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23
Q

Used for AIHA (Acquired Immune Hemolytic Anemia)
Paroxysmal nucturnal hemoglobinuria
rare patients with IgA deficiency
for allergic reactions

A

Washed RBC

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24
Q

Prolonged cell storage for rare blood donor units, autologous units and units for special purposes (intrauterine transfusion)

A

Frozen deglycerolized red blood cells

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25
Q

What process removes nearly all leukocytes and plasma

A

deglycerolization

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26
Q

200-250ml of Plasma Frozen at -18C within 8 hours of collection
no platetes available
contains all coagulation factors
treat multiple coagulation deficiencies
not to be used for blood volume expansion or protein replacement

A

FRESH FROZEN PLASMA

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27
Q

FFP used to treat for patients with?

A 
liver failure
Vit. K deficiency
massive transfusion
DIC
warfarin toxicity
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28
Q

safer products such as:

A

serum albumin, synthetic colloids, balanced salt solutions

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29
Q

the cold insoluble portion of plasma that precipitates when FFP has been thawed bet. 1-6C

A

CRYPRECIPITATED AHF or CRYOPRECIPITATE

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30
Q

volume of cyroprecipitate

A

10-15ml

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31
Q

thawing and pooling mins?

A

30mins

32
Q

replacement of fibrinogen indicated with patients with?

A

Liver Failure
DIC
massive transfusion
congenital fibrinogen deficiency

33
Q

CRRYP can also be a source of??

A

Factor VIII, FACTOR XIII, Von Willebrand Factor

34
Q

FVIII and Von Williebrand better treated with:

A

Factor VIII concentrate or with desmopressin acetate: DDAVP

35
Q

1U cryoprecipitate=

A

80-120 IU Factor VIII
150 or 250 mg fibrinogen
40-70% Von Willebrand factor
20-30% factor XIII

36
Q

Storage temp if 1year if frozen

A

-18C

37
Q

6 hours if thawed

A

20-24C

38
Q

if pooled?

A

4hrs

39
Q

used to correct fibrinogen level?

A

Cryoprecipitate transfusion

40
Q

This is essential for primary hemostatis

A

Platelet concentrate

41
Q

processed by unrefrigerated WB within how many hours?

A

6-8 hours after phlebotomy or apheresis

42
Q

PC used in patients suffering from thrombocytopenia as a result of problem in _____

A
  • defective production or decreased function

- induced destruction as a result of radiation and chemotherapy

43
Q

QC:

Random Donor Platelets:

A

5.5x10^10 platelets

44
Q

QC:

Single Donor Platelets:

A

3.0x10^11

45
Q

Storage of PC

A

20-24C (RT or aircon temp) with constant agitation

46
Q

Shelf life of PC

A

3-5 days (if pooles platelets within 4hrs of pooling)

47
Q

pH of PC

A

6.0

48
Q

This is prepared by CYTAPHERESIS

A

Granulocyte Concentrate/ Leukocyte Concentrate

49
Q

Each GC/LC contains how many granulocytes if steroid or HES or both are used?

A

1.0x10^10 granulocytes

50
Q

granulocyte concentrate contain _____ of plasma stored at _____ C without agitation

A

200-600 ml; 20-24C

51
Q

Granulocyte transfusions are done in:

A 
fever
septicemia
unresponsive to antibiotic
bone marrow hypoplasia
reasonable chance for patient survival
neonates with imapired neutrophil function
severe neutropenia
52
Q

Dosage for adults of GC/LC

A

one granulocytapheresis product for 4 or more days

53
Q

Dosage for neonates of GC/LC

A

a buffy coat or a granulocytapheresis unit given once or twice

54
Q

It is formerly known as liquid plasma or cryoprecipitate poor

A

Plasma

55
Q

Plasma has small amounts of what factor

A

Factor V and VIII

56
Q

Plasma is recommended for treatment of?

A

treatment of stable coagulation esp. Factor XI

source of plasma for pts. undergoing plasma exchange

57
Q

It is prepared by pharmaceutical firms by fractionation and lyophilization of pooled plasma

DERIVED FROM PLASMA BY PLASMAPHERESIS

A

Factor VIII concentrate

58
Q

FVIII conc. is tsored at ____ temp and is reconstituted with ____ at the time of infusion

A

refrigerated; saline

59
Q

FVIII conce used to treat:

A

hemophilia A or FVIII deficiency

60
Q

It is prepared from pooled plasma using various methods of separation and viral inactivation

A

Factor IX conc.

61
Q

Factor IX conc contains factors?

A

Factors II, VII, IX, X

62
Q

indicated only for factor IX deficiency

A

Hemophilia B

63
Q

It is the plasma left after separation from WB of the cellular components and cryoprecipitate

A

Cryosupernate

64
Q

Cryosupernate is used to treat:

A

bleeding disorders other than hemophilia
hypofribrinogemia
hypovolemia

65
Q

It is the RBCs and platelts exposed to gamma radiation at ____ for ____ mins

A

25 rads; 4.5minutes; GAMMA IRRADIATED RBC.

66
Q

It inactivates T lymphocytes in the donor unit and prevents graft versus host disease in an immunocompromised recipient

A

Gamma irradiated RBC

67
Q

A vitamin K dependent and a serine protease inhibitor

inactivates Factor V and VII preventing thrombus formation

A

Protein C

68
Q

It is used for patients with alpha-1 antitrypsin deficiency which is associated with emphysemia and liver diseases

A

Alpha protease inhibitor concentrates

69
Q

For the treatment life threatening angioedema of the mucosa and submucosa of the respiratory and gastrointestinal tract

A

C1 esterase inhibitor concentrates

70
Q

Four different types of autologous transfusion

A
  1. Preoperative collection
  2. Normovolemic hemodilution
  3. Intraoperative collection
  4. Postoperative “SHED” collection
71
Q

Blood is withdrawn and stored before the anticipated transfusion used for stable patients scheduled for surgical procedure

A

Preoperative collection

72
Q

Collection of 1 or more units of blood the beginning of surgery with replacement of patients blood vol using crystalloids or colloid solutions. Blood is reinfused during or at the end of surgery.

A

Normovolemic hemodilution

73
Q

Blood is collected during a surgical procedure by aspiration from the surgical site. It is then processed and is reinfused to the patient during or immediately after sugery

A

Intraoperative collection

74
Q

Collection of blood from a drainage tube placed in the surgical site and reinfusion following open heart and traumatic hemothorax

A

Postoperative “SHED” Collection

75
Q

Donor- patient may donate blood every ___ days but not within ____ hrs. surgery to allow the patient plasma to go back to normal b4 surgery

A

3 days;72hrs

76
Q

_____mg of ferrous sulfate or ferrous gluconate is given 3 times daily as iron supplement if several units are required within a few weeks.

A

320mg

BLOOD COMPONENT (1 decks)

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