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BLOOD COMPONENT Flashcards

1
Q

HARD SPIN/HEAVY SPIN

5000g- 5mins

A

PRBC PC

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2
Q

HARD SPIN

5000g - 7mins

A

CRYOPPT, LP-RBC, CELL FREE PLASMA

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3
Q

LIGHT SPIN OR SOFT SPIN

2000G-3MINS

A

PRP

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4
Q

Replace the loss of both RBC mass and plasma volume in actively bleeding patients. loss of 25% of their blood volume

A

Whole blood

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5
Q

No viable platelets or WBC

A

Whole blood

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6
Q

Decreased labile: Factors V/ VIII

A

Whole blood

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7
Q

Days of exchange transfusion?

A

6 days

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8
Q

Treatment of symptomatic anemia where oxygen capacity is needed

A

Packed red blood cells

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9
Q

Tolerate an increased blood volume

A

Packed red blood cells

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10
Q

Adavantages of RBC over whole blod

A
  1. Equal O2 in half vlume of WB
  2. Reductions of isoagglutinins
  3. Reduction in the kevels of acid, citrate, and potassium w/ cardiac, renal, liver
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11
Q

For neonates

A

RBC ALIQUOTS

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12
Q

Treatment of anemia caused by:

A
  1. FETOMATERNAL HEMORRHAGE
  2. OBSTETRIC ACCIDENTS
  3. INTERNAL HEMORRHAGE
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13
Q

Average unit of RBC contains ____

A

2x10^9 leukocytes

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14
Q

a reduced leukocyte content to less than _____

A

5x10^8

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15
Q

prevents repeated non-hemolytic febrile trans reaction

A

Leukocyte Reduced Red Blood Cells

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16
Q

less than 5x10^6 prevents what?

A

HLA sensitization

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17
Q

how to reduce immunosuppression of recipient by?

A

donor WBC

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18
Q

prevents alloimmunization to ____

A

HLA antigens, CMV transmission and recurrent FNH reactions

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19
Q

TRUE OR FALSE: does not prevent graft versus disease

A

TRUE

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20
Q

What generation and pore size?

screen filter- removes fibrin clots

A

First 170-260um

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21
Q

What generation and pore size?

micropore screen filter-remove aggregates such as plt., nuclei, degenerated WBC, cell fragments, and nuclei

A

Second 20-40um

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22
Q

What generation and pore size?

Adhesion filter- removes 99.9% of WBC leaving less than 5x10^8 WBC

A

Third NA

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23
Q

Used for AIHA (Acquired Immune Hemolytic Anemia)
Paroxysmal nucturnal hemoglobinuria
rare patients with IgA deficiency
for allergic reactions

A

Washed RBC

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24
Q

Prolonged cell storage for rare blood donor units, autologous units and units for special purposes (intrauterine transfusion)

A

Frozen deglycerolized red blood cells

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25
What process removes nearly all leukocytes and plasma
deglycerolization
26
200-250ml of Plasma Frozen at -18C within 8 hours of collection no platetes available contains all coagulation factors treat multiple coagulation deficiencies not to be used for blood volume expansion or protein replacement
FRESH FROZEN PLASMA
27
FFP used to treat for patients with?
``` liver failure Vit. K deficiency massive transfusion DIC warfarin toxicity ```
28
safer products such as:
serum albumin, synthetic colloids, balanced salt solutions
29
the cold insoluble portion of plasma that precipitates when FFP has been thawed bet. 1-6C
CRYPRECIPITATED AHF or CRYOPRECIPITATE
30
volume of cyroprecipitate
10-15ml
31
thawing and pooling mins?
30mins
32
replacement of fibrinogen indicated with patients with?
Liver Failure DIC massive transfusion congenital fibrinogen deficiency
33
CRRYP can also be a source of??
Factor VIII, FACTOR XIII, Von Willebrand Factor
34
FVIII and Von Williebrand better treated with:
Factor VIII concentrate or with desmopressin acetate: DDAVP
35
1U cryoprecipitate=
80-120 IU Factor VIII 150 or 250 mg fibrinogen 40-70% Von Willebrand factor 20-30% factor XIII
36
Storage temp if 1year if frozen
-18C
37
6 hours if thawed
20-24C
38
if pooled?
4hrs
39
used to correct fibrinogen level?
Cryoprecipitate transfusion
40
This is essential for primary hemostatis
Platelet concentrate
41
processed by unrefrigerated WB within how many hours?
6-8 hours after phlebotomy or apheresis
42
PC used in patients suffering from thrombocytopenia as a result of problem in _____
- defective production or decreased function | - induced destruction as a result of radiation and chemotherapy
43
QC: | Random Donor Platelets:
5.5x10^10 platelets
44
QC: | Single Donor Platelets:
3.0x10^11
45
Storage of PC
20-24C (RT or aircon temp) with constant agitation
46
Shelf life of PC
3-5 days (if pooles platelets within 4hrs of pooling)
47
pH of PC
6.0
48
This is prepared by CYTAPHERESIS
Granulocyte Concentrate/ Leukocyte Concentrate
49
Each GC/LC contains how many granulocytes if steroid or HES or both are used?
1.0x10^10 granulocytes
50
granulocyte concentrate contain _____ of plasma stored at _____ C without agitation
200-600 ml; 20-24C
51
Granulocyte transfusions are done in:
``` fever septicemia unresponsive to antibiotic bone marrow hypoplasia reasonable chance for patient survival neonates with imapired neutrophil function severe neutropenia ```
52
Dosage for adults of GC/LC
one granulocytapheresis product for 4 or more days
53
Dosage for neonates of GC/LC
a buffy coat or a granulocytapheresis unit given once or twice
54
It is formerly known as liquid plasma or cryoprecipitate poor
Plasma
55
Plasma has small amounts of what factor
Factor V and VIII
56
Plasma is recommended for treatment of?
treatment of stable coagulation esp. Factor XI | source of plasma for pts. undergoing plasma exchange
57
It is prepared by pharmaceutical firms by fractionation and lyophilization of pooled plasma DERIVED FROM PLASMA BY PLASMAPHERESIS
Factor VIII concentrate
58
FVIII conc. is tsored at ____ temp and is reconstituted with ____ at the time of infusion
refrigerated; saline
59
FVIII conce used to treat:
hemophilia A or FVIII deficiency
60
It is prepared from pooled plasma using various methods of separation and viral inactivation
Factor IX conc.
61
Factor IX conc contains factors?
Factors II, VII, IX, X
62
indicated only for factor IX deficiency
Hemophilia B
63
It is the plasma left after separation from WB of the cellular components and cryoprecipitate
Cryosupernate
64
Cryosupernate is used to treat:
bleeding disorders other than hemophilia hypofribrinogemia hypovolemia
65
It is the RBCs and platelts exposed to gamma radiation at ____ for ____ mins
25 rads; 4.5minutes; GAMMA IRRADIATED RBC.
66
It inactivates T lymphocytes in the donor unit and prevents graft versus host disease in an immunocompromised recipient
Gamma irradiated RBC
67
A vitamin K dependent and a serine protease inhibitor | inactivates Factor V and VII preventing thrombus formation
Protein C
68
It is used for patients with alpha-1 antitrypsin deficiency which is associated with emphysemia and liver diseases
Alpha protease inhibitor concentrates
69
For the treatment life threatening angioedema of the mucosa and submucosa of the respiratory and gastrointestinal tract
C1 esterase inhibitor concentrates
70
Four different types of autologous transfusion
1. Preoperative collection 2. Normovolemic hemodilution 3. Intraoperative collection 4. Postoperative "SHED" collection
71
Blood is withdrawn and stored before the anticipated transfusion used for stable patients scheduled for surgical procedure
Preoperative collection
72
Collection of 1 or more units of blood the beginning of surgery with replacement of patients blood vol using crystalloids or colloid solutions. Blood is reinfused during or at the end of surgery.
Normovolemic hemodilution
73
Blood is collected during a surgical procedure by aspiration from the surgical site. It is then processed and is reinfused to the patient during or immediately after sugery
Intraoperative collection
74
Collection of blood from a drainage tube placed in the surgical site and reinfusion following open heart and traumatic hemothorax
Postoperative "SHED" Collection
75
Donor- patient may donate blood every ___ days but not within ____ hrs. surgery to allow the patient plasma to go back to normal b4 surgery
3 days;72hrs
76
_____mg of ferrous sulfate or ferrous gluconate is given 3 times daily as iron supplement if several units are required within a few weeks.
320mg

BLOOD COMPONENT (1 decks)

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