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Blood And Immunity > Blood Coagulation > Flashcards

Blood Coagulation Flashcards

1
Q

Factor I

A

Fibrinogen. Liver. 2000-4000 microgram/mL.
To fibrin by IIa, stabilised by XIIIa
Structural mesh work
Acute phase reactant

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2
Q

Factor II

A 
Prothrombin. Activated by Xa
Fibrinogen to fibrin
Activator of platelets
Procarboxypeptidase B, inhibits plasmin mediated fibrinolysis 
Anticlotting activity
Wound healing

Vitamin K dependent

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3
Q

Factor III

A

Tissue thromboplastin
Extrinsic mechanism of blood coagulation
VII to VIIa, then X to Xa

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4
Q

Factor IV

A

Calcium, X to Xa, prothrombin to thrombin

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5
Q

Factor V

A

Proaccelerin
Accelerates prothrombin to thrombin
X to Xa

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6
Q

Factor VII

A

Proconvertin
Activated to tissue factor
Activates X to Xa
Also IX to IXa

Vitamin K dependant

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7
Q

Factor VIII

A

Antihemophilic factor
Activated by Xa, thrombin
Converts X to Xa
Bound to vWF

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8
Q

Factor IX

A

Vitamin K dependent
Christmas factor
Activated by XIa or VIIa/TF complex
X to Xa

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9
Q

Factor X

A

Stuart Prower factor
Vitamin K dependent
Activated by IXa and VIIa
Converts prothrombin to thrombin

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10
Q

Factor XI

A

Plasma thromboplastin or Antihemophilic factor C
Activated by XIIa, accelerated by kininogen
Contact factors

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11
Q

Factor XII

A

Hageman’s factor
Contact actuvation, along with HMW kininogen and prekallikrein
Converts XI to XIa

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12
Q

Factor XIII

A

Laki-Lorand factor
Fibrin stabilising
Activated by thrombin

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13
Q

HMW kininogen, prekallikrein

A

HMW- nonenzymatic function in contact activation.

Prekallikrein- complex with factor XI and HMW kininogen

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14
Q

Thrombomodulin
Protein C
Protein S
Tissue factor pathway inhibitor

A

Thrombomodulin+thrombin- protein C activated.
Protein C- vit K dependent
Protein S- cofactor for protein C, inactivates Va and VIIIa
TFPI- inhibits Xa and VIIa

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15
Q

Mechanism of blood coagulation

A

Stage 1: Activation of Stuart Prower factor
Stage 2: conversion of prothrombin to thrombin
Stage 3: formation of fibrin from fibrinogen

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16
Q

Intrinsic and extrinsic mode

A

I: IX, enzyme cascade
E: TPL, VII

17
Q

Formation of fibrin from fibrinogen

A

Proteolysis of soluble fibrinogen
Polymerisation of fibrin monomers
Stabilisation of fibrin polymer

Proteolysis- by thrombin
Poly- protofibrils
Stab- XIIIa

18
Q

Clot retraction

A 
Mechanism, platelet, filipodia, contraction, internalization
Thrombin and calcium
Function: seal strongly
Wound healing
Prevent thrombolysis
19
Q

Anticlotting mechanism naturally occurring

A

Anticoagulants
Vascular endo
Thromboxane A2 with prostacyclin

20
Q

Mechanism of fibrinolysis

A

Activation of protein C
Activation of plasmin
Fibrinolysis

Thrombomodulin, inactivate inhibitors of plasmin activator, inactivate Va and VIIIa
Fibrin to fibrin degradation products (FDP) by cofactors thrombin, tissue type plasminogen activator, urokinase type plasminogen activator

Blood And Immunity (2 decks)

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