Blood Coagulation Flashcards
Define blood coagulation
Blood coagulation is a process by which nlood loses its fluidity and becomes a jelly like mass, thereby forming a clot
Factor v ?
Labile factor ( proaccelerin or accelerator )
Factor I
Fibrinogen
Factor II
Prothrombin
Factor IX
Christmas factor, antihemophilic factor B
Factor XIII
Fibrin stabilizing factor ( fibrinogen )
Factor XII
Hageman factor ( contact factor )
Factor III
Thromboplastin ( tissue factor )
Factor IV
Calcium
Factor X
Stuart Prower factor
Factor VI
Presence has not been proved
Factor VII
Stable factor
Factor VIII
Antihemophilic factor A ( antihemophilic globulin )
Factor XI
Plasma thromboplastin antecedent, antihemophilic factor C
What are the stages of blood coagulation ?
1) formation of prothrombin activator
2) conversion of prothrombin to thrombin
3) conversion of fibrinogen to fibrin
How is intrinsic Pathway for the formation of prothrombin activator activated ?
Initiated by platelets within the blood
What are the sequence of events in intrinsic Pathway ?
1) during injury the blood vessel is ruptured. Endothelium is damaged and collagen beneath the endothelium is exposed
2) Factor XII comes in contact with collagen and is converted into activated factor XII I’m the presence of kallikrein and high molecular weight kinogen ( HMW )
3) the activated factor XII converts factor XI into activated factor II in the presence of HMW kinogen
4) activated factor XI activates factor IX in the presence of factor IV
5) activated factor IX activates factor X in the presence of factor VIII and calcium
6) when platelets come in contact with collagen of damaged blood vessels, it gets activated and releases phospholipids
7) the activated factor X reacts with platelet phospholipids and factor V to form prothrombin activator. This is done in the presence of calcium ions.
