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Blood Physiology > Blood Coagulation > Flashcards

Blood Coagulation Flashcards

1
Q

Define blood coagulation

A

Blood coagulation is a process by which nlood loses its fluidity and becomes a jelly like mass, thereby forming a clot

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2
Q

Factor v ?

A

Labile factor ( proaccelerin or accelerator )

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3
Q

Factor I

A

Fibrinogen

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4
Q

Factor II

A

Prothrombin

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5
Q

Factor IX

A

Christmas factor, antihemophilic factor B

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6
Q

Factor XIII

A

Fibrin stabilizing factor ( fibrinogen )

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7
Q

Factor XII

A

Hageman factor ( contact factor )

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8
Q

Factor III

A

Thromboplastin ( tissue factor )

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9
Q

Factor IV

A

Calcium

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10
Q

Factor X

A

Stuart Prower factor

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11
Q

Factor VI

A

Presence has not been proved

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12
Q

Factor VII

A

Stable factor

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13
Q

Factor VIII

A

Antihemophilic factor A ( antihemophilic globulin )

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14
Q

Factor XI

A

Plasma thromboplastin antecedent, antihemophilic factor C

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15
Q

What are the stages of blood coagulation ?

A

1) formation of prothrombin activator
2) conversion of prothrombin to thrombin
3) conversion of fibrinogen to fibrin

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16
Q

How is intrinsic Pathway for the formation of prothrombin activator activated ?

A

Initiated by platelets within the blood

17
Q

What are the sequence of events in intrinsic Pathway ?

A

1) during injury the blood vessel is ruptured. Endothelium is damaged and collagen beneath the endothelium is exposed

2) Factor XII comes in contact with collagen and is converted into activated factor XII I’m the presence of kallikrein and high molecular weight kinogen ( HMW )

3) the activated factor XII converts factor XI into activated factor II in the presence of HMW kinogen

4) activated factor XI activates factor IX in the presence of factor IV

5) activated factor IX activates factor X in the presence of factor VIII and calcium

6) when platelets come in contact with collagen of damaged blood vessels, it gets activated and releases phospholipids

7) the activated factor X reacts with platelet phospholipids and factor V to form prothrombin activator. This is done in the presence of calcium ions.

Blood Physiology (2 decks)

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