Blood cell lineage

Question 1

Erythropoiesis

Answer 1

the process which produces red blood cells (erythrocytes), which is the development from erythropoietic stem cell to mature red blood cell (erythrocytes).

Question 2

hemopoiesis

Answer 2

The production of blood cells

Question 3

Where hemopoiesis happens before birth?

Answer 3

primarily in the liver and spleen

but some cells develop in the thymus, lymph nodes, and red bone marrow

Question 4

Where hemopoiesis happens AFTER birth?

Answer 4

most production is limited to red bone marrow in specific regions

but some white blood cells are produced in lymphoid tissue.

Question 5

Where are all blood cells from?

Answer 5

stem cell (pleuripotential cells or hemocytoblasts).

Question 6

Blood cell lineage

Answer 6

Seven different cell lines, each controlled by a specific growth factor, develop from the hemocytoblast.

When a stem cell divides, one of the “daughters” remains a stem cell and the other becomes a precursor cell, either a lymphoid cell or a myeloid cell. These cells continue to mature into various blood cells.

see the figure

Question 7

Blood cell lineage

Answer 7

When a stem cell divides, one of the “daughters” remains a stem cell and the other becomes a precursor cell, either a lymphoid cell or a myeloid cell. These cells continue to mature into various blood cells: erythrocytes, granulocytes, agranulocytes, and thrombocytes.

see the figure

Question 8

what are the granulocytes?

Answer 8

basophil, eosinophil, neutrophil, mast cell

A type of immune cell that has granules (small particles)

Question 9

what are the agranulocytes?

Answer 9

lymphocyte, monocyte

Lymphocyte gives rise to T cell, B cell and NK cell

Monocyte gives rise to macrophage and dendritic cells

Question 10

What are the thrombocytes?

Answer 10

from megakaryocytes

Also called platelet

help form blood clots to slow or stop bleeding and to help wounds heal

Question 11

What are the leukocytes?

Answer 11

granulocytes and agranulocytes

Question 12

what are the erythrocytes?

Answer 12

red blood cells

Question 13

What is Basophilia?

Answer 13

A higher than normal level of basophils.

Basophilia may be a sign you have an infection, or it may be a sign of serious medical conditions like leukemia or autoimmune disease

Question 14

What is eosinophilia?

Answer 14

A higher than normal level of eosinophils.

This condition most often indicates a parasitic infection, an allergic reaction or cancer.

Question 15

What is thrombocytosis?

Answer 15

A higher than normal level of thrombocytes (platelets)

may indicate an infection

Question 16

Dendritic cells (DCs)

Answer 16

Dendritic cells (DCs) are professional antigen presenting cells that inform the fight against invasive pathogens while enforcing tolerance to self and harmless environmental antigens.

They capture pathogens and receive signals from pathogens that influence the outcome of immune responses.