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Life Science Review-Pathology > Blood Cell Disorders > Flashcards

Blood Cell Disorders Flashcards

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1
Q

Signs and symptoms of beta thalassemia major

A

severe anemia*, fatigue, stunted growth, skeletal deformation, splenomegaly, poikilocytes

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2
Q

What disorder looks like there are “hairs on end” on a skull X ray?

A

beta thalassemia major

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3
Q

What disorder shows “lace-like trabeculation” on X ray?

A

beta thalassemia major

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4
Q

How does one diagnose autoimmune hemolytic anemias?

A

via the “direct Coombs antiglobulin test”

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5
Q

What is the vector for malaria?

A

female Anopheles mosquito

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6
Q

How does one diagnose infectious mononucleosis?

A

via a monospot test to check for EBV antibodies

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7
Q

What happens to the blood cells in the thalassemia disorders?

A

red blood cells are destroyed via hemolysis

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8
Q

Which thalassemia disorder is lethal in utero?

A

alpha thalassemia

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9
Q

Describe the signs and symptoms of beta thalassemia minor

A

asymptomatic or minor anemia with a normal life span

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10
Q

What are examples of oxidants that could exacerbate G6PD deficiency?

A

infections, aspirin, fava beans

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11
Q

Which blood cell disorder is known for having a Philadelphia chromosome?

A

chronic myelogenous leukemia

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12
Q

What is the prognosis for CML?

A

good with tyrosine kinase inhibitor meds
good with stem cell transplants
3 year survival if it goes into blast crisis

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13
Q

Which type of leukemia has a poor prognosis, even with treatment?

A

acute myeloid leukemia

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14
Q

What type of leukemia is known for having Auer rods?

A

AML

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15
Q

Myelodysplastic syndromes have what kind of prognosis?

A

1-2 years after diagnosis, unless it turns into AML, then it has a poor prognosis

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16
Q

40% of myelodysplastic syndromes transform into what condition?

A

AML

17
Q

What are the signs and symptoms of primary myelofibrosis?

A 
anemia
thrombocytopenia
poikilocytes
severe extramedullary hematopoiesis
massive splenomegaly
18
Q

What are the signs and symptoms of essential thrombocytopenia?

A

most asymptomatic
increased platelet production
splenomegaly, thrombosis
hemorrhage

19
Q

What is the prognosis for primary myelofibrosis?

A

poor, commonly diagnosed late

4-5 years after diagnosis

20
Q

What is the prognosis for essential thrombocythemia?

A

no impact on lifespan as long as they have medical management of thrombocytes

Life Science Review-Pathology (1 decks)

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