Blood Brain Barrier (BBB) Flashcards
What do tight junction of blood brain barrier do
Seal together the endothelial cells of brain blood capillaries
Blood brain barrier consists of
tight junctions and basement membrane
What does the blood brain barrier thick basement membrane do
Surrounds the capillaries
Substances able to pass freely from blood into brain tissue
Lipid-soluble substances, small molecules(ex. O2, CO2) and most anesthetic agents
Substances unable to pass from blood into brain tissue
Proteins, large molecules and most antibiotic drugs
How are water-soluble substances able to pass from blood into brain tissue
Active transport
How is creatinine, urea, and most ions able to pass from blood into brain tissues
Very slowly
How are proteins, large molecules, and most antibiotic drugs able to pass from blood into brain tissue
Unable to pass
How does lipid-soluble substances(ex. O2, CO2, most anesthetic agents) and small molecules pass from blood into brain tissue
Pass freely
