Blood Banking/Products Flashcards

1
Q

Composition of Blood

A
  • mostly plasma and RBCs

- WBCs 3% and platelets 1%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Indications for Fresh Frozen Plasma

A
  • vitamin K deficiency
  • warfarin toxicity
  • massive blood loss
  • DIC (disseminated intravascular coagulopathy)
  • multiple coagulation problems due to liver failure
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Indications for Platelets

A
  • thrombocytopenia (<10,000 if asymptomatic)

- massive blood loss

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Indications for PRBCs

A
  • hemodynamically unstable
  • leukemic processes
  • hemolytic anemia
  • other anemias
  • increase in O2 carrying capacity
  • surgical or traumatic blood loss
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Volume of 1 unit of PRBCs

A

250 mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Presentation of Patient Needing PRBCs (signs, sxs)

A
  • high pulse and RR
  • HoTN
  • low O2 sats
  • dizziness, weakness
  • angina
  • altered mental status
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is albumin used for?

A
  • not used often

- burn pts b/c they have lost a lot of fluid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What does albumin do when given to a patient?

A

-brings osmotic pressure of intra and extravascular space back to normal in hypovolemia and hyperproteinemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What surface antigens and antibodies are present in type O blood?

A
  • no surface antigen

- anti-A and anti-B antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What surface antigens and antibodies are present in type A blood?

A
  • A surface antigen

- anti-B antibody

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What surface antigens and antibodies are present in type B blood?

A
  • B surface antigen

- anti-A antibody

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What surface antigens and antibodies are present in type AB blood?

A
  • A and B surface antigens

- no antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is type and screen compatibility testing?

A
  • recipient’s blood tested for its type

- also screened for atypical antibodies (Kell, Duffy, Lewis, MN, etc)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is type and crossmatch compatibility testing?

A
  • recipient’s blood tested for its type
  • also screened for atypical antibodies (Kell, Duffy, Lewis, MN, etc)
  • mix together sample of recipient and donor blood to look for agglutination (agglutination = BAD, no agglutination = compatible)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the universal donor for RBC?

A

O negative blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the universal donor for FFP?

A

type AB

17
Q

What causes hemolytic transfusion reactions?

A

ABO incompatibility

18
Q

How do hemolytic transfusion reactions present?

A
  • donor RBCs are lysed and contents get into bloodstream and kidneys = damage
  • acute kidney failure
  • acute tubular necrosis
  • shock
  • DIC
19
Q

Treatment for Hemolytic Transfusion Reactions

A
  • EMERGENCY
  • STOP transfusion
  • maintain airway
  • start saline IV
20
Q

What causes febrile non-hemolytic transfusion reactions?

A

-interleukins and TNF alpha

21
Q

How do febrile non-hemolytic transfusion reactions present?

A
  • fever
  • chills
  • rigor
  • mild dyspnea
22
Q

Treatment for Febrile Non-Hemolytic Transfusion Reactions

A
  • stop transfusion
  • Tylenol and/or Benadryl
  • symptomatic tx
23
Q

What causes delayed hemolytic transfusion reactions?

A
  • atypical antibodies present in recipient

- occurs 2-10 days post-transfusion

24
Q

How do delayed hemolytic transfusion reactions present?

A
  • less severe than acute reactions
  • falling hematocrit
  • slight fever
25
Q

Treatment of Delayed Hemolytic Transfusion Reactions

A

-no tx necessary

26
Q

Presentation of Anaphylactic Transfusion Reactions

A
  • shock
  • HoTN
  • angioedema
  • respiratory distress
27
Q

Treatment of Anaphylactic Transfusion Reactions

A
  • stop transfusion
  • epinephrine
  • maintain airway
  • IV saline
28
Q

Post-Transfusion Purpura

A
  • very rare

- associated w/ sensitization to foreign antigen from previous platelet-containing transfusion

29
Q

Post-Transfusion Purpura Presentation

A

severe thrombocytopenia in 5-10 days

30
Q

Post-Transfusion Purpura Treatment

A
  • high dose corticosteroids or exchange transfusion

- or IVIG high dose x5 days

31
Q

Transfusion Related Acute Lung Injury

A
  • rare
  • actual cause unclear
  • possibly anti-granulocytes initiating immune inflammatory response
32
Q

What are some complications of blood transfusions?

A
  • fluid overload
  • iron overload
  • coagulation defects
  • hypocalcemia, hyperkalemia
  • hypothermia
  • air embolism