BLOOD BANK EXAM 1

Question 1

Who is known as “father of blood banking”?

Answer 1

Karl Lansteiner, discovered the ABO blood group

Question 2

What type of antibody response usually causes problems for transfusion pts?

Answer 2

Secondary

Question 3

Which cell functions primarily in antigen processing presentation?

Answer 3

Macrophage

Question 4

In the classis pathway of complement action..

Answer 4

C3 is split into C3a & C3b

Question 5

Which Ig class would be most important in the study of immune-mediated transfusion rxns due to the prescence of alloantibodies?

Answer 5

IgG

Question 6

The antibody produced during the secondary response to a foreign antigen is usually…

Answer 6

present @ a higher titer that after a primary response

Question 7

In ea individual there is one pair of sex chromosomes. The remaining 22 prs of chromosomes are called:

Answer 7

autosomes

Question 8

What is the predominant class of ab found in the serum of neonates after full term gestation?

Answer 8

IgG

Question 9

After exposure to Ag, the 1st Abs that can be detected belong to the class:

Answer 9

IgM

Question 10

Which subclass of Ab, referred to as incomplete Ab, is able to agglutinate RBCs after antihuman Ab is added?

Answer 10

IgG

Question 11

A deficiency of which Ig class has been implicates in anaphylactic rxns due to transfusions of plasma?

Answer 11

IgA

Question 12

Mendel made a series of crosses btwn true-breeding strains of plants that differed only by 1 characteristic: short vs tall. The 1st filial gen was all tall plants. Describe the relationship btwn the tall & short traits?

Answer 12

Tall is a dominant trait

Question 13

From monohybrid crosses Mendel determined that yellow pea seeds (Y) are dom & green seeds (y) are recessive. When heterzygous yellow-seeded plants are crossed with green-seeded, what is the expected ratio of yellow to green seeds in the offspring?

Answer 13

2 yellow to 2 green

Question 14

What type of serological testing does the blood bank tech perform when determining the blood group of a patient?

Answer 14

Phenotyping

Question 15

Which genotype is heterozygous for Fy b?

Answer 15

Fy(a+b+)

Question 16

A principle of the antiglobulin test is:

Answer 16

AHG reacts w/ human globulin molecules bound to RBCs or free in serum.

Question 17

Polyspecific AHG reagent contains:

Answer 17

anti-IgG & anti-C3d

Question 18

Monoclonal anti-C3d is:

Answer 18

derived from one clone of plasma cells

Question 19

Red cells are classified as A2 if:

Answer 19

they react with anti-A but not w/ anti-A1

Question 20

which genotype(s) will give rise to the Bombay phenotype?

Answer 20

hh only

Question 21

The enzyme responsible for conferring A1 activity on the red cell membrane is alpha-:

Answer 21

N-acetylgalactosaminyl transferase

Question 22

Which sugar must be present on a precursor subst for A & B antigenic activity to be expressed?

Answer 22

L-fucose