BLOOD BANK EXAM 1 Flashcards
Who is known as “father of blood banking”?
Karl Lansteiner, discovered the ABO blood group
What type of antibody response usually causes problems for transfusion pts?
Secondary
Which cell functions primarily in antigen processing presentation?
Macrophage
In the classis pathway of complement action..
C3 is split into C3a & C3b
Which Ig class would be most important in the study of immune-mediated transfusion rxns due to the prescence of alloantibodies?
IgG
The antibody produced during the secondary response to a foreign antigen is usually…
present @ a higher titer that after a primary response
In ea individual there is one pair of sex chromosomes. The remaining 22 prs of chromosomes are called:
autosomes
What is the predominant class of ab found in the serum of neonates after full term gestation?
IgG
After exposure to Ag, the 1st Abs that can be detected belong to the class:
IgM
Which subclass of Ab, referred to as incomplete Ab, is able to agglutinate RBCs after antihuman Ab is added?
IgG
A deficiency of which Ig class has been implicates in anaphylactic rxns due to transfusions of plasma?
IgA
Mendel made a series of crosses btwn true-breeding strains of plants that differed only by 1 characteristic: short vs tall. The 1st filial gen was all tall plants. Describe the relationship btwn the tall & short traits?
Tall is a dominant trait
From monohybrid crosses Mendel determined that yellow pea seeds (Y) are dom & green seeds (y) are recessive. When heterzygous yellow-seeded plants are crossed with green-seeded, what is the expected ratio of yellow to green seeds in the offspring?
2 yellow to 2 green
What type of serological testing does the blood bank tech perform when determining the blood group of a patient?
Phenotyping
Which genotype is heterozygous for Fy b?
Fy(a+b+)
A principle of the antiglobulin test is:
AHG reacts w/ human globulin molecules bound to RBCs or free in serum.
Polyspecific AHG reagent contains:
anti-IgG & anti-C3d
Monoclonal anti-C3d is:
derived from one clone of plasma cells
Red cells are classified as A2 if:
they react with anti-A but not w/ anti-A1
which genotype(s) will give rise to the Bombay phenotype?
hh only
The enzyme responsible for conferring A1 activity on the red cell membrane is alpha-:
N-acetylgalactosaminyl transferase
Which sugar must be present on a precursor subst for A & B antigenic activity to be expressed?
L-fucose
