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Histology > Blood and hematopoiesis > Flashcards

Blood and hematopoiesis Flashcards

1
Q

Plasma %

A

55% of whole blood

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2
Q

Erythrocytes %

A

44% of whole blood

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3
Q

Buffy coat

A

Leukocytes and platelets ; <1% of whole blood

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4
Q

Water content of plasma

A

92%

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5
Q

Plasma proteins

A

7% of plasma

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6
Q

Solute content of plasma

A

<1%

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7
Q

Albumin functions

A

Maintain osmotic pressure in capillaries; contribute to blood viscosity; transports fatty acids, electrolytes, hormones, and drugs

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8
Q

Alpha globulin func

A

Transports lipids and metal ions

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9
Q

Beta globulin function

A

Transports iron ions and lipids in bloodstream

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10
Q

Gamma globulin function

A

Antibodies :)

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11
Q

Fibrinogen

A

Blood clotting; precursor of fibrin

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12
Q

Zone of Pallor

A

1/3 of RBC center

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13
Q

Lifespan of RBC

A

120 days

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14
Q

Normal values for platelets

A

150,000-400,000 mm^3

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15
Q

Lifespan of platelets

A

10 days

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16
Q

Hyalomere

A

Lightly stained peripheral zone

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17
Q

Granulomere

A

Darkly stained central zone

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18
Q

Contents of delta granules

A

ATP, ADP, serotonin

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19
Q

Contents of alpha granules

A

Platelet derived growth factor, platelet factor 4, platelet specific proteins

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20
Q

Site of RBC breakdown

A

Liver, spleen, bone marrow

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21
Q

Carbaminohemoglobin

A

HgB with CO2

22
Q

Carboxyhemoglobin

A

Hgb with CO

23
Q

Normal values of leukocytes

A

4,500-11,000/mm^3

24
Q

% of Neutrophils

A

50-70%

25
Q

% of Lymphocytes

A

20-40%

26
Q

% of Monocytes

A

2-8%

27
Q

% of Eosinophils

A

1-4%

28
Q

% of Basophils

A

0.5-1%

29
Q

Drumstick-like appendage on neutrophils

A

Barr-body

30
Q

Myeloperoxidase

A

Generates hypochlorite and other substance against bacteria

31
Q

Lysozyme

A

Degrades bacterial cell walls

32
Q

Defensins

A

Cysteine-rich proteins that bind and disrupt cell membranes

33
Q

Neutrophils

A

Weakly staining granules

34
Q

Eosinophils

A

Golden-red staining

35
Q

Basophils

A

Dark purple staining granules

36
Q

Bands

A

Immature neutrophils with horse-shoe shaped nucleus

37
Q

3-5 lobed leukocyte

A

Neutrophil

38
Q

Bilobed leukocyte

A

Eosinophil

39
Q

S-shaped bilobed

A

Basophils

40
Q

Open canalicular system of vesicles

A

Uptake of factors from plasma

41
Q

Dense tubular system of irregular tubular vesicles

A

Rapid degranulation; exocytosis of proteins

42
Q

Cytokines

A

Trigger loosening of intercellular junctions

43
Q

P-selectin

A

Cell adhesion proteins on endothelial luminal surface; exocytosed from weibel-palade bodies

44
Q

erythroid progenitor cell

A

Proerythroblast

45
Q

sequence of erythropoiesis

A

proerythroblast -> basophilic erythroblast -> polychromatophilic erythroblast -> orthochromatophilic eryth -> reticulocyte -> erythrocyte

46
Q

stage when pyknotic nucleus is ejected

A

orthochromatophilic erythroblast

47
Q

normoblast

A

orthochromatophilic erythroblast

48
Q

sequence of granulopoiesis

A

progenitor cell (CFU-G) -> myeloblast -> protomyelocyte -> myelocyte -> metamyelocyte -> mature granulocyte

49
Q

4 compartments of neutrophils

A

granulopoietic compartment, storage compartment, circulating compartment- marginating compartment

50
Q

sequence of thrombopoiesis

A

megakaryoblast -> megakaryocyte with proplatelet extensions -> platelet

Histology (2 decks)

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