Blood Flashcards

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1
Q

What are the main functions of blood?

A
  • Carriage of biologically active material and gases.
  • Clotting
  • Defence
  • Maintenance of ECF pH
  • Thermoregulation
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2
Q

What are the three types of plasma proteins?

A
  1. Albumin
  2. Globulin
  3. Fibrinogen and clotting factors
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3
Q

What is meant by colloidal oncotic pressure?

A

This is the ‘pull’ created by plasma proteins. It pulls water across the endothelial cells of the capillary wall. Sodium can follow, long with other penetrating components of the ISF.

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4
Q

What can Red Blood Cells also be called?

A

Erythrocytes

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5
Q

Describe the structure of erythrocytes.

A

Biconcave disk shape, without a nucleus. This allows more space for haemoglobin.

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6
Q

What is erythropoiesis?

A

This is the development of erythrocytes from pluripotent stem cells, accelerated by erythropoietin.

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7
Q

What is the most abundant blood cell?

A

Erythrocyte

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8
Q

Describe the structure of platelets.

A

Cell fragments

Megakaryocyte cytoplasm wrapped up in megakaryocyte membrane. No nucleus

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9
Q

What are the three types of granulocytes?

A

Eosinophils
Neutrophils
Basophils

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10
Q

What do monocyte cells mature into?

A

Macrophages

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11
Q

What is the function of macrophages?

A

To engulf and destroy pathogens in phagocytosis

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12
Q

What is the function of neutrophils?

A
  • Phagocytosis

- To trap pathogens in NETs (Neutrophil extracellular traps)

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13
Q

What is the function of eosinophils?

A

To attack pathogens which are too large for neutrophils and other defensive cells

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14
Q

In what scenario is eosinophil count extremely elevated?

A

During an allergic reaction

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15
Q

What is the function of basophils?

A

To release histamine and heparin to stimulate inflammation

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16
Q

Which is the largest white blood cell?

A

Monocyte

17
Q

Which is the most abundant white blood cell?

A

Neutrophil

18
Q

What controls white blood cell formation?

A

Cytokines

19
Q

Which WBC is used to attack parasites?

A

Eosinophils

20
Q

Describe the process of haemotaxis.

A

Infected cells produce a chemical messenger, which diffuses throughout the ECF, staying strongest at site of infection. The chemical enters blood stream and alerts WBCs. The chemical then acts as a trail, leading WBC to site of infection.

21
Q

What is the name given to the process of WBC formation?

A

Leukopoiesis

22
Q

Describe the process of leucopoiesis.

A
  • Cytokines are released from endothelial cells, fibroblasts and mature WBCs.
  • Stimulate mitosis and maturation of leaukocytes
  • Composition of cytokine cocktail changes as a result of particular infection
  • For example, in the event of a bacterial infection, cytokine cocktail is required to stimulate the synthesis of more neutrophils than usual.
23
Q

What WBC is best for neutralising bacterial pathogens?

A

Neutrophils

24
Q

What WBC is best for neutralising viral pathogens?

A

Lymphocytes

25
Q

What protein controls the formation of platelets?

A

Thrombopoietin

26
Q

What is the function of platelets?

A

Adhere to damaged vessels and connective tissue to mediate blood clotting

27
Q

What is meant by the viscosity of blood?

A

How thick it is compared to water

28
Q

What is the role of erythropoietin?

A

Stimulates the creation of erythroblasts from pluripotent stem cells?

29
Q

What increases the secretion of erythropoietin?

A

Decreased delivery of oxygen to the kidney (e.g. through haemorrhage, anaemia, lung disease or cardiac dysfunction.

30
Q

What is meant by haematocrit?

A

The volume percentage of RBCs in blood.
Typically 40-54% in males
Typically 37-47% in females

31
Q

What three factors affect blood viscosity?

A

Haematocrit, temperature and flow rate