Blood Flashcards
Plasma Composition
Albumins 60% (FA thyroid, steroid hormones)
Globulins 35% (AB binding proteins)
Fibrinogen 4% clots, make ling insoluble fibrin
Reg Proteins 1% Insulin prolactin thyroid stim horm LH
RBC Life Cycle
Made in BM –> 120 days –> Liver and spleen eat–>
Erythropoiesis
Occurs in myeloid tissue (Red bone marrow)
Requires
-Folic acid, Iron, Vitamins B12 and B6, Amino Acids
-EPO
Pernicious Anemia
Low RBC production due to lack of B12
Polycythemia
too many RBC
Strains heart
Anemia
Gew RBC, low O2 levels
Iron deficiency anemia (lack of iron or chronic blood loss)
-Sickle cell
Leukocyte/WBC Circulation
Most WBC are in connective tissue proper or lymphatic system organs
Small # in blood
Chemotaxis–> Diapedisis
Granulocytes
Neutrophils- Phagocytize, pus
Eosinophil
Basophil- histamine, heparin
Agranulocytes
Lymphocyte- larger than RBC, between blood & lymph
T cells, B Cells, Natural killers
Monocyte- Migrate to eat patho, recruit fibrocyte and imm cells
B-lymphocytes
Humoral immunity
Differentiate into plasma cells
Make antibodies
T lymphocytes
Cell-mediated
Attack foreign pathogens
Natural Killers
Detect and kill
Leukopoiesis
Myeloid stem cells make all WBC except lymphocytes
Lymphopoeisis
Within red none marrow hematopoietic SC differentiate in to lymphoid stem cells.
Those that travel to the thyroid become T-cells and those that stay become B cells and NK
Thrombocytes (platelets) Functions
Release coltting chemicals
Temporarily patch vessels
Reduce size of break
