Block Five Flashcards
Cardiovascular Drugs
Define inotropic and chronotropic effects.
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- Describe the cardiac stimulants’ mode of action and adverse effects and routes of administration.
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- Describe drug interactions and monitoring details required for digoxin and be able to state the antidote for digoxin.
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- Describe the peripheral vasodilators’ mode of action and adverse effects.
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- Describe the formulations and storage properties of the nitrates.
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- Understand the clinical application of adrenaline and dopamine for cardiac insufficiency.
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A drug has a positive inotropic and positive chronotropic effect. What does this mean?
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What type of inotropic and chronotropic effect does the
B-agonists have?
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When adrenaline is used, bronchodilation and pupil
dilation can occur. Why do these adverse effects occur?
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With constant dosing of digoxin it would take more than
a week to reach steady state level. Why?
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If the therapeutic effects are required more quickly what would the dosing regimen be?
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Therapeutic drug monitoring is important for this drug.
Why?
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What is the inotropic and chronotropic effect of digoxin
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Why do these digoxin adverse effects occur?
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How are glyceryl trinitrate products administered? Explain.
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What is a common adverse effect of nitrates that occurs early in the course of administration? How is the adverse effect treated?
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Write True or False for the following statements.
If digoxin is given with diuretics, the serum K+ should be
monitored.
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Glyceryl Trinitrate is given to relieve angina rapidly.
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Dopamine has a negative inotropic effect
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Adrenaline is a positive chronotrope.
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Adverse effects associated with GTN are facial flushing and headaches.
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Digoxin is a negative inotrope and positive chronotrope.
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Dopamine given at different doses, low, moderate and high will have the same effect.
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- Why must the potassium levels be monitored when a person is taking digoxin?
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