Block 13 Flashcards
What percentage of deaths are caused by CVD in UK for men and women?
28% - men
26% - women
Globally most common cause of disease:
Cardiovascular disease
Globally where are rates of CVD highest?
Eastern Europe, North Africa + Middle East
Globally where are CVD rates lowest
Western Europe, Canada + Australia
What percentage of Coronary Heart disease causes death in men? (2019)
13%
What percentage of Coronary Heart disease causes death in women? (2019)
8%
Where are CHD rates lowest in UK?
Southeast
Where are CHD rates highest in UK?
North of England and Wales
Since 1970s how have CHD death rates changed
significant decrease in mortality rates from CHD deaths in men and women
How does general deprivation affect CHD death rates?
Where there is more general deprivation CHD rates are higher
How are CHD rates affected by social position?
As you move away from professional high-skilled jobs into more manual jobs that are generally lower paid, CHD rates increase
How does place of birth effect CHD mortality?
South Asian: India, Pakistan, Bangladesh => higher CHD death rates
List drugs that are risk factors for cardiovascular disease
Contraceptives
Nucleoside analogues
COX-2 inhibitors
Rosiglitazone
Non-modifiable risk factors for CHD
- Age
- Male sex
- Positive FHx
- Deletion polymorphism in ACE enzyme
Risk
probability of an event in a given time period
Risk difference is also known as
Attributable risk
Why might CHD death rates decrease as you move up social classes?
Because higher social classes are associated with better health behaviours
Define population attributable risk
What proportion of disease in a population is attributable to a particular risk factor e.g. how much risk of CVD is down to smoking
3 main risk factors for global burden of CVD
Smoking - > regular smoking of more than 10 cigarettes a day
Cholesterol - > 3.8mm/mol
Blood pressure - SBP greater than 115mmHg
Prevention paradox
preventive measure that offers large benefit to the community but little benefit to each participating individual
2 main strategies for Primary prevention
Population approach
High risk strategy - subgroup of population targeted
Outline a population approach strategy to primary prevention
reducing burden of disease across entire pop by modifying pop behaviour or a specific parameter
Outline a high risk strategy to primary prevention
target high risk sub group of population an aim to move them to lower risk level
List the pros and cons of population approach to prevention
Pros
- large potential
Cons
- subjects poorly motivated
- low benefit:risk ratio
- sml individual benefit **prevention paradox
Which gender has a declining incidence of lung cancer?
Men
Leading most common cause of cancer deaths
Lung cancer
Peak incidence of lung cancer is between ages:
65-75
Risk factors for lung cancer
- Smoking - passive and being a smoker
- Radon - 2nd leading cause of cancer
- Occupational carcinogen exposure - arsenic, chromium, nickel, beryllium, silica
- Only using open fires for heating + cooking
- Environmental air pollution
- Previous radiation exposure
How has global incidence of TB changed overtime?
1800s - TB caused more than 30% of all deaths in Europe
1940s - antibiotics introduce, TB incidence declined
Globally, where are most new cases of TB?
Southeast Asia - 45`%
Africa - 25%
Western Pacific (17%) - China, Japan, Phillipines + Australia etc.