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Veterinary General Pathology > Block 1 > Flashcards

Block 1 Flashcards

1
Q

Which of the following is energy independent?
A. Necrosis
B. Apoptosis

A

A. Necrosis

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2
Q 
Which of the following is dependent on intracellular iron for cell death?
A. Pyroptosis
B. Paraptosis
C. Ferroptosis
D. Parthanatos
A

C. Ferroptosis

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3
Q

The displacement of the cytoplasm by large fluid-filled vacuoles derived from macropinosomes is a hallmark feature of?

A

Methuosis

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4
Q

The apoptosome is composed of what?

A

cytochrome c, dATP, Apaf-1, caspase 9

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5
Q

Which BCL-2 sensor is essential for deletion of autoreactive B&T cells during development?

A

Bim

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6
Q 
Which of the following is an anti-apoptotic Bcl-2 regulators?
A. PUMA
B. Bim
C. Bcl-x
D. Bak
A

C. Bcl-x

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7
Q 
Cytochrome c is normally located where?
A. Endoplasmic reticulum
B. Within inner membrane of mitochondria
C. Between outer and inner membranes of mitochondria
D. Lysozomes
A

C. Between outer and inner membranes of mitochondria

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8
Q 
In the intrinsic pathway of apoptosis, which caspase is the initiator caspase?
A. Caspase 3
B. Caspase 7
C. Caspase 8
D. Caspase 9
A

D. Caspase 9

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9
Q 
Which caspase is the initiator caspase for extrinsic pathway of apoptosis?
A. Caspase 3
B. Caspase 7
C. Caspase 8
D. Caspase 9
A

C. Caspase 8

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10
Q 
Which of the following is an example of an IAP?
A. Survivin
B. Cytochrome c
C. Caspase 3
D. SMAC
A

A. Survivin

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11
Q 
Which of the following proteins is expressed during apoptosis to encourage phagocytosis of the cell?
A. PUMA
B. Apaf-1
C. Diablo
D. Phosphatidylserine
A

D. Phosphatidylserine

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12
Q 
Which of the following is a DNA repair enzyme that can be cleaved and used as a diagnostic tool for apoptosis?
A. Apaf-1
B. PARP
C. Survivin
D. Cytochrome c
A

B. PARP

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13
Q 
In the extrinsic pathway of apoptosis, FasL binds to what extracellular receptor?
A. FLIP
B. TRAIL
C. Pro-caspase 8
D. CD95
A

D. CD95

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14
Q 
Which of the following inhibits the activation of pro-caspase 8 to caspase 8?
A. C-FLIP
B. FADD
C. Bid
D. DIABLO
A

A. C-FLIP

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15
Q 
Which of the following is activated in the extrinsic pathway of apoptosis and activates the intrinsic pathway?
A. IAPs
B. Bid
C. Caspase 8
D. C-FLIP
A

B. Bid

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16
Q 
Which of the following is a shock caspase?
A. Caspase 6
B. Caspase 7
C. Caspase 9
D. Caspase 11
A

D. Caspase 11

17
Q 
Necroptosis is mediated by which of the following?
A. Bcl-2 proteins
B. MPTP
C. Cytochrome-c
D. Fas
A

B. MPTP

18
Q 
Ligation of TNFR1 recruits RIP-1 and RIP-3 into a complex with which caspase?
A. Caspase 6
B. Caspase 8
C. Caspase 11
D. Caspase 13
A

B. Caspase 8

19
Q 
Which protein serves as a marker for a lysozome to bind with an autophagosome?
A. LC3
B. Hsp 70
C. Ubiquitin
D. Hsp 60
A

A. LC3

20
Q 
Which protein serves as a chaperone to bring proteins into the mitochondria?
A. Hsp 70
B. Hsp 60
C. Ubiquitin
D. C-FLIP
A

B. Hsp 60

21
Q 
What complex serves as the major upstream inhibitor of autophagy?
A. Beclin-1 complex
B. MTORC-1 complex
C. ULK complex
D. PI3KC1 complex
A

B. MTORC-1 complex

22
Q 
Which complex activates mTORC1?
A. ULK1/ULK2
B. PI3KC1
C. Atg 13
D. Beclin-1
A

B. PI3KC1

23
Q

Name the components of the MTORC1

A

MTOR, raptor, Deptor, PRAS40, GbetaL

Veterinary General Pathology (1 decks)

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