Block 1 Flashcards
1
Q
Which of the following is energy independent?
A. Necrosis
B. Apoptosis
A
A. Necrosis
2
Q
Which of the following is dependent on intracellular iron for cell death? A. Pyroptosis B. Paraptosis C. Ferroptosis D. Parthanatos
A
C. Ferroptosis
3
Q
The displacement of the cytoplasm by large fluid-filled vacuoles derived from macropinosomes is a hallmark feature of?
A
Methuosis
4
Q
The apoptosome is composed of what?
A
cytochrome c, dATP, Apaf-1, caspase 9
5
Q
Which BCL-2 sensor is essential for deletion of autoreactive B&T cells during development?
A
Bim
6
Q
Which of the following is an anti-apoptotic Bcl-2 regulators? A. PUMA B. Bim C. Bcl-x D. Bak
A
C. Bcl-x
7
Q
Cytochrome c is normally located where? A. Endoplasmic reticulum B. Within inner membrane of mitochondria C. Between outer and inner membranes of mitochondria D. Lysozomes
A
C. Between outer and inner membranes of mitochondria
8
Q
In the intrinsic pathway of apoptosis, which caspase is the initiator caspase? A. Caspase 3 B. Caspase 7 C. Caspase 8 D. Caspase 9
A
D. Caspase 9
9
Q
Which caspase is the initiator caspase for extrinsic pathway of apoptosis? A. Caspase 3 B. Caspase 7 C. Caspase 8 D. Caspase 9
A
C. Caspase 8
10
Q
Which of the following is an example of an IAP? A. Survivin B. Cytochrome c C. Caspase 3 D. SMAC
A
A. Survivin
11
Q
Which of the following proteins is expressed during apoptosis to encourage phagocytosis of the cell? A. PUMA B. Apaf-1 C. Diablo D. Phosphatidylserine
A
D. Phosphatidylserine
12
Q
Which of the following is a DNA repair enzyme that can be cleaved and used as a diagnostic tool for apoptosis? A. Apaf-1 B. PARP C. Survivin D. Cytochrome c
A
B. PARP
13
Q
In the extrinsic pathway of apoptosis, FasL binds to what extracellular receptor? A. FLIP B. TRAIL C. Pro-caspase 8 D. CD95
A
D. CD95
14
Q
Which of the following inhibits the activation of pro-caspase 8 to caspase 8? A. C-FLIP B. FADD C. Bid D. DIABLO
A
A. C-FLIP
15
Q
Which of the following is activated in the extrinsic pathway of apoptosis and activates the intrinsic pathway? A. IAPs B. Bid C. Caspase 8 D. C-FLIP
A
B. Bid
16
Q
Which of the following is a shock caspase? A. Caspase 6 B. Caspase 7 C. Caspase 9 D. Caspase 11
A
D. Caspase 11
17
Q
Necroptosis is mediated by which of the following? A. Bcl-2 proteins B. MPTP C. Cytochrome-c D. Fas
A
B. MPTP
18
Q
Ligation of TNFR1 recruits RIP-1 and RIP-3 into a complex with which caspase? A. Caspase 6 B. Caspase 8 C. Caspase 11 D. Caspase 13
A
B. Caspase 8
19
Q
Which protein serves as a marker for a lysozome to bind with an autophagosome? A. LC3 B. Hsp 70 C. Ubiquitin D. Hsp 60
A
A. LC3
20
Q
Which protein serves as a chaperone to bring proteins into the mitochondria? A. Hsp 70 B. Hsp 60 C. Ubiquitin D. C-FLIP
A
B. Hsp 60
21
Q
What complex serves as the major upstream inhibitor of autophagy? A. Beclin-1 complex B. MTORC-1 complex C. ULK complex D. PI3KC1 complex
A
B. MTORC-1 complex
22
Q
Which complex activates mTORC1? A. ULK1/ULK2 B. PI3KC1 C. Atg 13 D. Beclin-1
A
B. PI3KC1
23
Q
Name the components of the MTORC1
A
MTOR, raptor, Deptor, PRAS40, GbetaL
