Blistering Dermatoses

Question 1

3 blistering disorders due to immunoglobulins

Answer 1

pemphigus vulgaris: IgG against desmosomes
bullous pemphigoid: IgG against hemidesmosomes
dermatitis herpatiformis: IgA at dermal papillae

Question 2

Pemphigus vulgaris vs bullous pemphigoid

Answer 2

pemphigus vulgaris:
-IgG against desmosomes
-oral mucosa involvement
-reticular (net-like) on IF
-Nikolsky +
bullous pemphigoid:
-IgG against hemidesmosomes
-oral mucosa not involved
-linear on IF
-Nikolsky - (and not easily ruptured)

Question 3

Dermatitis herpetiformis

pathology

Answer 3

IgA deposition at tips of dermal papillae
small vesicles form
celiac association

Question 4

Erythema multiforme and more severe forms

Answer 4

hypersensitivity rxn due to drugs, other
dusky centers (central necrotic region)
EM –> SJ syndrome (10-30%) –> TEN ( >30%)