Bleeding Flashcards
DDx for small animal bleeding?
- Haemorrhage
- IMTP
- vWD
- Canine lungworm
- Vitamin K deficiency
- Strep equi zooepidemicus
- Canine herpesvirus
- Melaena
- Haemophilia A/B
- DIC
- Vasculitis
- Hepatopathy
Examples of haemorrhage?
Internal - spleen, thorax, trauma, amyloidosis (hepatic cats)
External - epistaxis, gastro, parasitic infection, urinary tract
What should you check in the bleeding patient?
TP/PCV
Coagulation profile
Platelet count
Faecal lungworm
What are the three types of vWD?
Type I - all mulitmers are present but a a decreased conc. => variable severity of bleeding (DOBERMANS)
Type II - Qualitative abnormalities in vWF structure and function, severe and uncommon
Type III - Absence of all vWF mutlimers
Diagnotics for vWD?
Measure levels of vWF:Afg, vWF levels will be decreased by clots in the sample and haemolysis
ELISA
Genetic test for carriers
Treatment for vWD?
Transfusion to supply vWF
Cryoprecipitate - concentration of vWF is 5-10x greater than plasma
Whole blood if animal is anaemic
Desmopressin as a pre-operative prophylactic as it causes vWF release
Clinical signs of vWD?
Mucosal bleeding (GI, epistaxis, haematuria) No petechiae
Clinical signs of canine lungworm?
Cardioresp signs, coagulopathies, neurological signs
Subcut haematomas, internal haemorrhage, prolong wound bleeding
Treatment of lungworm?
Moxidectin - single dose (advocate)
Vitamin K dependent factors?
II, VII, IX and X
Test results of vitamin K deficiency?
Elevation in PT and APTT, platelet numbers and buccal mucosal bleeding times
Tx for vitamin K deficiency?
Emetics, cathartics, activated charcoal if ingestion of rodenticide
Transfusions of whole fresh blood or FFP to replace coag factors
Vitamin K therapy - orally
How does strep zooepidemicus cause bleeding in dogs?
Inhaled - haemorrhagic pnuemonia - pyrexia, haemorhagic nasal discharge and sudden death
How is strep zooepidemicus diagnosed in dogs?
Isolation from lung samples/swabs
Treatment of strep zooepidemicus?
ABs and antibiotics
How would you treat gastric ulcers in dogs?
Gastroprotectants
DDx if platelet count is abnormal?
Primary immune mediated
Secondary immune mediated
Myeoproliferative disease